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Anybody got a lead on methylphenidate?

2,014 Views | 12 Replies | Last: 2 yr ago by 94chem
94chem
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This is ridiculous. 75 year old drug with a fairly routine synthesis. What's the next shortage? Caffeine? Corn syrup? Ethyl alcohol?
94chem,
That, sir, was the greatest post in the history of TexAgs. I salute you. -- Dough
AgLiving06
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Thank government for it.

We have a couple brands identified for our son that's on ADHD so he can jump around depending on availability.

94chem
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AgLiving06 said:

Thank government for it.

We have a couple brands identified for our son that's on ADHD so he can jump around depending on availability.


I looked at the structure, and it has 2 chiral centers, so that means 4 possible products. Mix in the time-release varieties, etc., and it's hard to know what you're actually getting, and how it compares to what you were taking.

Do you know anything that acts like immediate release Ritalin? We're concerned about the effects of time release on sleep and eating. I suppose it could be ground into a powder.

This is just a mess.
94chem,
That, sir, was the greatest post in the history of TexAgs. I salute you. -- Dough
AggieT
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AG
What about dexmethylphenidate? (Focalin)
AJ02
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AG
Focalin makes me so sleepy. I had to stop taking it. But I never had any problem getting the prescription filled.
Jack Klompus
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AG
We were getting it at HEB for my son with ADHD. HEB hasn't had it for about 2 months now. We switched to Kroger just down the road, and they haven't had an issue. Supposedly, the national chains (Kroger, Walmart) have a better supply chain than the regional chains (HEB). YMMV.

Edit: He's on an extended release version.
94chem
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Got some last night. Total luck at CVS. The pharmacy wasn't keeping any waiting list, so we just had to check every day.

And in other news, the FDA finally admits what we've all known for 30 years. Phenylephrine doesn't work, and should have never replaced pseudoephedrine. Unfortunately, it was 20 years before I realized you could get pseudoephedrine with a driver's license and didn't need a prescription.
94chem,
That, sir, was the greatest post in the history of TexAgs. I salute you. -- Dough
bigtruckguy3500
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94chem said:


And in other news, the FDA finally admits what we've all known for 30 years. Phenylephrine doesn't work, and should have never replaced pseudoephedrine. Unfortunately, it was 20 years before I realized you could get pseudoephedrine with a driver's license and didn't need a prescription.
I thought this was old news. I've at least I've been telling people this for the past 7-8 years.

Regardless. I agree. The drug shortages are ridiculous. It seems every few weeks there's another shortage. This has really been going on since the hurricane hit Puerto Rico a few years ago. They have a lot of medical manufacturing there, and then COVID, and then labor shortages, etc. Something or the other has been leading to one shortage after another.
htxag09
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AG
Can't this shortage pretty much be directly tied to government mandating how much can be manufactured and increase in demand going up when allowing prescriptions without an in person visit?
bigtruckguy3500
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htxag09 said:

Can't this shortage pretty much be directly tied to government mandating how much can be manufactured and increase in demand going up when allowing prescriptions without an in person visit?
I'm not sure. Hypothetically, not requiring an in person visit shouldn't increase consumption of drugs, unless you're saying people are getting prescribed things they don't need because the doc can't tell without an inperson visit?

I'm not aware of the government mandating that drug companies stop producing after they've reached a certain volume of drugs.

I know a lot of raw materials come from all over the world, especially China. India makes a lot of drugs for the international market as well. And between quality control issues overseas, and supply chain issues there as well, things from those countries aren't getting shipped here, or weren't.

Things are definitely on a constant shortage on a revolving basis. One month it's lorazepam, another it's propofol, then it's amoxicillin, even over the counter children's tylenol and ibuprofen, and even magnesium citrate, were shortage.

I'm not privy to all that's going on behind the scenes, but as far as I know the government isn't limiting production of any of those.
htxag09
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AG
Definitely not an expert on the matter. But I just recall this from a WSJ podcast I listened to. The podcast was specific to adderall.

https://www.wsj.com/podcasts/the-journal/whats-behind-the-adderall-shortage/96dfbed0-5a11-4a25-b4fa-8bb86c5cf575

Quote:

It's made of amphetamines and can be addictive and abused, so it's regulated by the Drug Enforcement Administration.

Rolfe Winkler: Adderall is a Schedule 2 controlled substance for a reason. There are a lot of people that don't legitimately have ADHD that want it because it's a wonder drug and it will make you focus on things.

Kate Linebaugh: That's our colleague, Rolfe Winkler.

Rolfe Winkler: You have a lot of people chasing those prescriptions. Now, because of that, the DEA regulates it, and part of the DEA regulation is putting an aggregate production quote on the amount that is allowed to be made. There's a fixed pie.


Quote:

Speaker 2: Let me show you the easiest way to get ADHD care. This company called Done makes it so easy with this three step process. First, take a one-minute assessment to see if Done is right for you. If it's a match, you can schedule a same day or next day appointment with one of their licensed ADHD clinicians. They also make it super...

Kate Linebaugh: Tell me about Done. What is this company?

Rolfe Winkler: Done was a company that basically jumped into this business by working with a whole bunch of nurse practitioners as contractors. They set up the platform. They'll advertise on social media. They'll draw you to their website where you answer a few questions, and then they assign you to a nurse practitioner who will see you for they say 30 minutes, but in our reporting, we found often sometimes 10 minutes or less, who will then diagnose ADHD and write you a prescription. They will charge you 80 bucks a month to continually write you your Adderall prescription.


Quote:

The number of prescriptions for Adderall was growing about 5% per year in 2019, and then again in 2020. Then in 2021, prescriptions jumped 10%. Then last year through October, they had jumped another 11%. There's a lot more demand in the marketplace.
bigtruckguy3500
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Oh, I see what you're saying. I thought you were talking about drug shortages in general.

Certainly possible. Direct to consumer marketing on a lot of drugs, and online pill mills masquerading as telemedicine clinics certainly aren't helping things. Most of them are pretty shady.
94chem
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Like I said in the first sentence...
94chem,
That, sir, was the greatest post in the history of TexAgs. I salute you. -- Dough
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