I am on a different med. I didn't really get any instructions or helpful advice, just heres the pills, take one twice a day. Well, 3-4 weeks into this I went on a guys fishing trip. I got way too drunk to take my pills at night and was way too hungover to take pills in the morning. Well, by the time I made it home on Sunday evening, it felt like my heart was going to beat clean out of my chest. I stopped halfway home and took a pill and then another at bedtime. I could hardly sleep that night until very late when the pills finally hit bottom. So, in short, don't skip the whole weekend! Miss a pill or two, no biggie, just don't miss a few in a row.