I've sold on Etsy. I don't think it was any different experience than selling something on Ebay. One thing is I was selling about the time there was a tax change in which Etsy is responsible for paying the sales tax. Beforehand, I had to pay the sales tax so that change made it easier but you will still need to keep accurate records in case audited.
I am pretty sure it is required if you plan to do "business" in Texas, but I also applied and received a Texas Sales and Use Permit which gives you an account with the comptroller to pay taxes.
Between selling on Amazon, Ebay, and Etsy, I think Etsy was the easiest followed by Ebay and lastly Amazon.
Etsy was easy to setup account, product page, and selling with very little hiccups from buyers.
Ebay was similar to Etsy but the buyers were more of a pain to deal with.
With Amazon, you have to jump through hoops to get product page created and sending in inventory if you are doing Amazon Prime. You get more sales being Prime but there are a ton more returns/negative comments, etc. Selling Self Fulfillment with Amazon, you don't get near the sales.
I had more sales through Ebay and Etsy than through Amazon self fullfillment but more with Prime than Ebay and Etsy.