From what I can tell the whole effort was shut down in 2012?

Can any of you medical types shed some light on this? If it was shut down in 2012 why?

https://www.google.com/amp/s/www.nbcnews.com/news/amp/ncna1150091

Not sure that should be the same case for vaccines like this.

One of my rules of thumb for media includes: Don't assume the headline summarizes the article.

I suspect there is more subtlety and nuance here than the title reflects. Note this excerpt:

Early efforts to develop a SARS vaccine in animal trials were plagued by a phenomenon known as "vaccine-induced enhancement," in which recipients exhibit worse symptoms after being injected something Fauci said researchers must be mindful of as they work to quickly develop a vaccine to protect against COVID-19.

That kind of research figuring out which vaccine strategies work and which don't potentially could have been completed before the new outbreak, said Jason Schwartz, a professor at the Yale School of Public Health who studies vaccine development. He said the global response to the coronavirus exposes broader flaws in the way medical research is funded, which he says tends to be market-driven and reactive, rather than proactive.

I think the point is there was research that could have been done in the past that MIGHT have us closer to a vaccine for the disease caused by this virus. Perhaps it is something like "there are 4 steps in the process of getting a vaccine widely deployed. We could have been ready to skip step 1."

SARS and MERS died out in the human population and commercial and research interest declined.

agdaddy04 said:

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Not sure that should be the same case for vaccines like this.

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I completely agree.

In the future I think it will be much easier to get this type of funding, but this is something that hasn't been seen in a long time. People have short memories.

plain_o_llama said:

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One of my rules of thumb for media includes: Don't assume the headline summarizes the article.

I suspect there is more subtlety and nuance here than the title reflects. Note this excerpt:

Early efforts to develop a SARS vaccine in animal trials were plagued by a phenomenon known as "vaccine-induced enhancement," in which recipients exhibit worse symptoms after being injected something Fauci said researchers must be mindful of as they work to quickly develop a vaccine to protect against COVID-19.

That kind of research figuring out which vaccine strategies work and which don't potentially could have been completed before the new outbreak, said Jason Schwartz, a professor at the Yale School of Public Health who studies vaccine development. He said the global response to the coronavirus exposes broader flaws in the way medical research is funded, which he says tends to be market-driven and reactive, rather than proactive.

I think the point is there was research that could have been done in the past that MIGHT have us closer to a vaccine for the disease caused by this virus. Perhaps it is something like "there are 4 steps in the process of getting a vaccine widely deployed. We could have been ready to skip step 1."

SARS and MERS died out in the human population and commercial and research interest declined.

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Would probably have us closer to developing a vaccine with stronger evidence of safety. The bolded part is a serious concern and was previously observed in SARS and MERS vaccine development. We will need to keep fingers crossed that this does not happen in humans, but there appears to be decent prior evidence that the vaccines being rushed into clinical studies right now could result in making things worse.

Unfortunately, the current alternative is to stretch a 12-18 month timeline into several years, which isn't palatable right now. Here's to hoping for a bit of good luck.

Some of this is very technical, I only get some of it
Your mileage may vary.....

Vaccine talk and speculation with mention of antibody deficiency enhancement begins at 54:20
http://www.microbe.tv/twiv/twiv-591/

Lots of interesting topics are discussed.
Why children are not showing symptoms (43:50)
How coronavirus population immunity might develop in humans (47:20)
Scary super spreader anecdote from the past (38:20)

Haven't listened to it, wish there was a transcript instead. What I will say is that Ralph Baric is a solid researcher. I'm very familiar with him and believe he does solid work.

I'll have a listen at that section later tonight

In the next episode there is some discussion of the Moderna Phase 1 Vaccine trial.
Some general discussion about the approach and safety considerations at 14:50
http://www.microbe.tv/twiv/twiv-592/