https://www.nejm.org/doi/full/10.1056/NEJMoa2007016?query=featured_coronavirus
NSIAP.
Observational study with hospitalized COVID-19 pts requiring supplemental O2. 61 pts given the anti viral remdisivir.
"Of the 61 patients who received at least one dose of remdesivir, data from 8 could not be analyzed (including 7 patients with no post-treatment data and 1 with a dosing error). Of the 53 patients whose data were analyzed, 22 were in the United States, 22 in Europe or Canada, and 9 in Japan. At baseline, 30 patients (57%) were receiving mechanical ventilation and 4 (8%) were receiving extracorporeal membrane oxygenation. During a median follow-up of 18 days, 36 patients (68%) had an improvement in oxygen-support class, including 17 of 30 patients (57%) receiving mechanical ventilation who were extubated. A total of 25 patients (47%) were discharged, and 7 patients (13%) died; mortality was 18% (6 of 34) among patients receiving invasive ventilation and 5% (1 of 19) among those not receiving invasive ventilation."
Some context. In the Wuhan NEJM observational study overall mortality for COVID-19 admitted pts was 22% and 68% for those requiring intubation. So certainly promising.
NSIAP.
Observational study with hospitalized COVID-19 pts requiring supplemental O2. 61 pts given the anti viral remdisivir.
"Of the 61 patients who received at least one dose of remdesivir, data from 8 could not be analyzed (including 7 patients with no post-treatment data and 1 with a dosing error). Of the 53 patients whose data were analyzed, 22 were in the United States, 22 in Europe or Canada, and 9 in Japan. At baseline, 30 patients (57%) were receiving mechanical ventilation and 4 (8%) were receiving extracorporeal membrane oxygenation. During a median follow-up of 18 days, 36 patients (68%) had an improvement in oxygen-support class, including 17 of 30 patients (57%) receiving mechanical ventilation who were extubated. A total of 25 patients (47%) were discharged, and 7 patients (13%) died; mortality was 18% (6 of 34) among patients receiving invasive ventilation and 5% (1 of 19) among those not receiving invasive ventilation."
Some context. In the Wuhan NEJM observational study overall mortality for COVID-19 admitted pts was 22% and 68% for those requiring intubation. So certainly promising.
