Coronavirus = SARS + HIV ?

Bobcat06

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10:53a, 4/15/20

AG

Apparently, Coronavirus spike protein fuses with Ace2 proteins (like SARS) but also T-Cells (like HIV).

https://www.scmp.com/news/china/society/article/3079443/coronavirus-could-target-immune-system-targeting-protective

https://www.nature.com/articles/s41423-020-0424-9

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AgResearch

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11:15a, 4/15/20

AG

**** China

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Infection_Ag11

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11:25a, 4/15/20

AG

While this wouldn't be terribly surprising given how prevalent lymphopenia is in these patients, it's inaccurate to say it makes it equivalent to HIV. The defining characteristic of HIV is it's immune evasion and chronicity with immune destruction over time, not the fact that it attacks T-cells. If this is true, the drop in T-cells will be acute and recover in patients who survive.

I'll say the few HIV patients I've seen with this have had a dramatic decline in their CD4 counts despite compliance with their HAART, moreso than you would expect to normally see in an acute illness.

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SkiMo

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In reply to Infection_Ag11 • 11:31a, 4/15/20

AG

Infection_Ag11 said:
While this wouldn't be terribly surprising given how prevalent lymphopenia is in these patients, it's inaccurate to say it makes it equivalent to HIV. The defining characteristic of HIV is it's immune evasion and chronicity with immune destruction over time, not the fact that it attacks T-cells. If this is true, the drop in T-cells will be acute and recover in patients who survive.

I'll say the few HIV patients I've seen with this have had a dramatic decline in their CD4 counts despite compliance with their HAART, moreso than you would expect to normally see in an acute illness.

Any thoughts on PrEP as a possible short term management solution for coronavirus?

Not a Bot

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12:11p, 4/15/20

AG

MedCram did a video on this last night.

Probably nothing to be concerned about.

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Rock1982

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2:47p, 4/15/20

AG

Excellent Medcram video.

Ranger222

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9:56p, 4/15/20

AG

It seems that Cov-2 can infect T cells....but not replicate. Even the in vitro infection data is pretty thin with a lot of criticism regarding it during peer review.

94chem

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In reply to Ranger222 • 7:33a, 4/16/20

Ranger222 said:
It seems that Cov-2 can infect T cells....but not replicate. Even the in vitro infection data is pretty thin with a lot of criticism regarding it during peer review.

The T cells look like virus vacuums. Looks like we could attach proteins that dock Cov-2 to little Hoover bags, and collect the virus.