I know early on there seemed to be strong indications of susceptibility to infection or severity by blood type. Has anyone seen any more recent data on that subject?
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Status on susceptibility by blood type ?
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Last: 5 yr ago by murphyag
I have A positive and was interested when this reporting first started. Haven't seen follow up since. I do know that being obese and/or having Type 2 diabetes is something to be very concerned with.
There's a thread on this from a few days ago. The Aggie doctor Marcus Aurelius wrote this:
Quote:
Been reading about this. Along with viral inoculation amounts, I suspect it is the main source of variability of attack rates among affected individuals. Basically - type O is protective. Type A is susceptible. Type O blood is seen in 59-85% of Mexico and lower equatorial countries which have much lower cases of COVID-19.
Very complicated Sars Cov-2 apparently can't bind well to type O RBC surface proteins and when it tries it creates a highly antigenic protein bond structure that is easily cleared by native immunity.
Type A pts, on the other hand, apparently have different cell membrane serine protease activity, which interacts with serine residues on the viruses S spike protein. This is also governed by ACE-2 receptors, which have differing phenotypes in ABO variability. The cell glycan/S spike binding structure is affected by differing serine protease activity making it more easily penetrated. This all translates to easier sars cov2 human cell entry into type A individuals.
My read of complex topic.
I don't think there is a shred of currently available evidence to suggest this actually matters....
There was a small unpublished study from China that suggested Type A more susceptible but it was never published after peer review and since then nothing else on the topic....
There was a small unpublished study from China that suggested Type A more susceptible but it was never published after peer review and since then nothing else on the topic....
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Yeah, Marcus mentioned that a large portion of Mexico's population is O blood type. Sure doesn't seem to be helping them a whole lot at the moment.
Individual genomes respond differently to essentially every pathogen known to medicine. It is likely that covid-19 is no different. Unfortunately, the identification of specific genes will likely not occur until large databases exist for whole genome association studies. A red blood cell antigen is an unlikely candidate for cause of variable effects in individuals. The early Chinese study showing association of type A blood and resistance might reflect genetic linkage of a causative gene with the blood antigen gene in a population in which variants (alleles) of the two genes are inherited together (in disequilibrium) whereas in other populations the variants of the two genes may be in equilibrium and not appear to be associated. Larger studies with good clinical data and whole genome data are likely to lead to genes directly involved in differential pathogenesis between individuals, information which could subsequently facilitate development of therapeutics or vaccines.
but it seems like a very easy thing to find out. we know how many cases there are and surely blood types are being tracked, so why is the info not readily available?
IDK. According to Worldometer - 8200 total cases. 700 deaths. That's pretty light to me. Would figure Mexico City would be rocked.Player To Be Named Later said:
Yeah, Marcus mentioned that a large portion of Mexico's population is O blood type. Sure doesn't seem to be helping them a whole lot at the moment.
Right. Ecuador isn't faring too well either
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May be true. But being one who travels to Mexico frequently, I wouldn't really be too confident in any of Mexico's numbers being released. Their testing numbers are apparently incredibly low.Marcus Aurelius said:IDK. According to Worldometer - 8200 total cases. 700 deaths. That's pretty light to me. Would figure Mexico City would be rocked.Player To Be Named Later said:
Yeah, Marcus mentioned that a large portion of Mexico's population is O blood type. Sure doesn't seem to be helping them a whole lot at the moment.
It's been interesting to watch..... many small pueblos/villages have blockaded roads in and out and only letting residents in. If people think we have been authoritarian here, they really wouldn't like what's going on down there. They went real quick from "nothing to see or worry about here" to full on authoritarian police state. Friend of mine lives in Akumal and the police don't let anyone out and about except the absolute essentials.
I'll have to check around today for some more "on the ground" accounts from folks living there.
Would not surprise me. Numbers in Ecuador don't line up with reality either. Mainly because they just don't have the capacity to test.
Blood type wouldn't be some silver bullet for Mexico.
You've still got a ton of unhealthy people down there. Many of whom are types other than O. And no shortage of high density, unsanitary living conditions.
You've still got a ton of unhealthy people down there. Many of whom are types other than O. And no shortage of high density, unsanitary living conditions.
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Very true. If you think diabetes is an epidemic in the US......... check Mexico. And I'd imagine far more instances of uncontrolled diabetes than here at home.
Access to real medical care is going to be a major issue in the majority of the country. Likely to see high numbers of people who die that never got to a hospital.
Access to real medical care is going to be a major issue in the majority of the country. Likely to see high numbers of people who die that never got to a hospital.
and we will probably never hear about it.
One of the governors in Mexico came out early saying the most of Mexico had nothing to worry about because poor people are immune to Coronavirus.
One of the governors in Mexico came out early saying the most of Mexico had nothing to worry about because poor people are immune to Coronavirus.
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AMLO initially was telling everyone to keep going out to eat and spending money and that he wasn't worried because his lucky charm and lucky $2 bill would save him.Diggity said:
and we will probably never hear about it.
One of the governors in Mexico came out early saying the most of Mexico had nothing to worry about because poor people are immune to Coronavirus.
This is more to the topic of unbelievable low case counts in certain countries. There's a very high correlation between per capita income and covid cases, leading to the inference that lower income countries just don't have the testing resources.
Diggity said:
and we will probably never hear about it.
One of the governors in Mexico came out early saying the most of Mexico had nothing to worry about because poor people are immune to Coronavirus.
They' certainly seem to be immune to getting tested at any rate.
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I saw someone mention blood type in another thread and wondered to myself why people were still talking about that since every time I have looked for info, the only study I found was that first China study which started the conversation.
Well I looked again when someone asked about blood type today, and found this : https://www.medrxiv.org/content/10.1101/2020.04.08.20058073v1.full.pdf
Interesting, but certainly no suggestion you are at significantly more or less risk based on blood type alone.
Well I looked again when someone asked about blood type today, and found this : https://www.medrxiv.org/content/10.1101/2020.04.08.20058073v1.full.pdf
Interesting, but certainly no suggestion you are at significantly more or less risk based on blood type alone.
Mexico's deaths attributed to respiratory issues or pneumonia are up 55% YTD from last year.
The lack of numbers in CDMX are truly a mystery. Supposedly there are quite a few cases in Monterrey and Guadalajara, but it is folks with money and they are going on DL with it, in order to not be "discovered" by the government.
But more so are the numbers in Guyaquill, when about 250 miles away in Quito, numbers are very low.
The lack of numbers in CDMX are truly a mystery. Supposedly there are quite a few cases in Monterrey and Guadalajara, but it is folks with money and they are going on DL with it, in order to not be "discovered" by the government.
But more so are the numbers in Guyaquill, when about 250 miles away in Quito, numbers are very low.
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