COVID-19 Mutations

3,066 Views | 10 Replies | Last: 5 yr ago by Not a Bot
AggieFactor
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AG
I know its a study coming out of China so taking it with a grain of salt but ****. Bring on the anti-virals because who knows how effective the "vaccine" is even going to be.

https://www.jpost.com/HEALTH-SCIENCE/Coronavirus-has-mutated-into-at-least-30-different-strains-new-study-finds-625333
Aggie95
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AG
Reveille mentioned in his recent update that Coronavirus does not mutate easily so I'll be curious what other doctors say.
NASAg03
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Mutations don't necessarily mean vaccines won't work, and they also might be losing deadly characteristics, i.e. mutating to be less bad.
Mike Shaw - Class of '03
Infection_Ag11
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AG
The article is incredibly misleading, as there is a huge difference between 30 base pair mutations and 30 clinically different strains.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
Ranger222
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AG
The mutations arising within this virus should have no effect on vaccine development.
Infection_Ag11
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AG
Ranger222 said:

The mutations arising within this virus should have no effect on vaccine development.


I've become incredibly frustrated by the lack of responsibility demonstrated by print media during this pandemic. Stuff like this only serves to stoke the fire of fear, no better than those who continue to say "this is nothing".
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
DCAggie13y
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AG
Infection_Ag11 said:

Ranger222 said:

The mutations arising within this virus should have no effect on vaccine development.


I've become incredibly frustrated by the lack of responsibility demonstrated by print media during this pandemic. Stuff like this only serves to stoke the fire of fear, no better than those who continue to say "this is nothing".
To be fair, print media was irresponsible long before the pandemic started. Social media and the war for clicks has turned them all into Buzzfeed.
It is the tragedy of the world that no one knows what he doesn't know - and the less a man knows, the more sure he is he knows everything.
BiochemAg97
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AG
The virus mutates about every 2 infection cycles. This is know from many many genetic sequences that have been taken of the virus from many patients. That may sounds like a lot, but that is one change in a genome of 30,000 bases Importantly, those changes have not occurred in the particular parts that would effect the vaccine. There are a few proteins (spike and nucleocapsid) that are recognized by the immune system. Additionally, there are only parts of those proteins (epitopes) that the immune system cares about. This is a tiny portion of the genome.

There are a lot of changes that have no effect on the virus. For those that don't remember their biology/genetics, proteins are made up of 20 amino acids, and the sequence of amino acids is coded by our DNA which is made up of 4 bases. The amino acid sequence is dictated by codons of 3 bases. There is a lot of built in redundancy as 3 bases is 64 different combinations to encode 20 amino acids (and stop codons). So some mutations don't even change the amino acid. Other mutations swap one amino acid for another very similar amino acid that has minimal effect on the protein, and still other mutations occur in non-coding regions (not in one of the codons).

There are a lot of mutations (perhaps most mutations) that will have no effect on the virus. Since there are several other proteins, there are mutations that will alter the virus in other ways but not the immune response. And even mutations that change the amino acid sequence of S or N may not effect immunity if they don't change one the epitopes.

And finally, your immune system makes lots of different antibodies to a virus recognizing a variety of epitopes. A change to one epitopes may only effect one type of antibody and your immune system can still recognize the virus is a lot of other ways.

And one final comment, polyclonal antibodies to SARS-CoV spike protein recognize the spike protein of SARS-CoV2 which causes COVID-19. That is at least 17 years worth of divergent mutation in the virus in the bats that doesn't alter immunity. Probably more because SARS supposedly passed from bats to civets to humans.
RandyAg98
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AG
I have read a lot of irresponsible reporting during this pandemic, but that might be near the top.
Ranger222
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AG
Spoke too soon --

Just released an 81 bp deletion mutant in ORF7a found in a virus sequenced by Arizona State.

No data on how this might effect the virus given it is only sequence

An 81 base-pair deletion in SARS-CoV-2 ORF7a identified from sentinel surveillance in Arizona (Jan-Mar 2020)
FTAG 2000
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AG
AggieFactor said:

I know its a study coming out of China so taking it with a grain of salt but ****. Bring on the anti-virals because who knows how effective the "vaccine" is even going to be.

https://www.jpost.com/HEALTH-SCIENCE/Coronavirus-has-mutated-into-at-least-30-different-strains-new-study-finds-625333
People need to ignore what's coming out of China. We're effectively at war (not just us, the world) with China.

Unleashed this crap virus on the world. Sending faulty/corona infected PPE to Europe (and a few places in the U.S. stupid enough to buy), now the disinformation campaign with stuff like this, that it's U.S. developed and released, etc.

The world needs to send the CCP back to the 1700s.
Not a Bot
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AG
From the link Ranger posted:

Quote:


We found that the SARS-CoV-2 AZ-ASU2923 genome harbored an 81 base-pair deletion in the ORF7a gene resulting in a 27 amino-acid in-frame deletion ( Figure 2B ).
The SARS-CoV ORF7a ortholog is a viral antagonist of host restriction factor BST-2/Tetherin and induces apoptosis (11-14). Based on the SARS-CoV ORF7a structure (15), the 27-aa deletion in SARS-CoV-2 ORF7a maps to the putative signal peptide (partial) and first two beta strands.


If I'm reading this correctly, the virus mutated and deleted part of the gene that helps it evade the immune system? If so, large mutations like this may explain why outbreaks in certain communities seem to be more widespread / deadly than others.
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