Another weakening mutation found

3,269 Views | 6 Replies | Last: 5 yr ago by BusterAg
Snap E Tom
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6:42p, 4/22/20
https://www.medrxiv.org/content/10.1101/2020.04.17.20069641v1

Preprint out of ASU. Above my paygrade, but in other discussions, this deletion has to do with a removing a defense barrier that the virus has, making it more susceptible to a certain type of immunoresponse.
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Not a Bot
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11:38p, 4/22/20
AG
Quote:

We found that the SARS-CoV-2 AZ-ASU2923 genome harbored an 81 base-pair deletion in the ORF7a gene resulting in a 27 amino-acid in-frame deletion ( Figure 2B ).
The SARS-CoV ORF7a ortholog is a viral antagonist of host restriction factor BST-2/Tetherin and induces apoptosis (11-14). Based on the SARS-CoV ORF7a structure (15), the 27-aa deletion in SARS-CoV-2 ORF7a maps to the putative signal peptide (partial) and first two beta strands.


Basically seems like it deleted part of the genome responsible for helping the virus evade detection/destruction.

Conjecture:
Given this strain may be less "potent" it could fizzle itself out or (hopefully) spread rapidly and asymptomatically across more of the population. The rest of the virus should hopefully provide some antibodies to fight/kill the more rough strains.
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Snap E Tom
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In reply to Not a Bot • 2:04a, 4/23/20
Moxley said:
Quote:

We found that the SARS-CoV-2 AZ-ASU2923 genome harbored an 81 base-pair deletion in the ORF7a gene resulting in a 27 amino-acid in-frame deletion ( Figure 2B ).
The SARS-CoV ORF7a ortholog is a viral antagonist of host restriction factor BST-2/Tetherin and induces apoptosis (11-14). Based on the SARS-CoV ORF7a structure (15), the 27-aa deletion in SARS-CoV-2 ORF7a maps to the putative signal peptide (partial) and first two beta strands.


Basically seems like it deleted part of the genome responsible for helping the virus evade detection/destruction.

Conjecture:
Given this strain may be less "potent" it could fizzle itself out or (hopefully) spread rapidly and asymptomatically across more of the population. The rest of the virus should hopefully provide some antibodies to fight/kill the more rough strains.
Virologists at Fred Hutch think it's going to end up being one of the many common-cold coronaviruses out there today.

It raises the question of whether a vaccine will end up being financially viable especially if it takes a while to make such a vaccine and the virus keeps mutating to be less deadly.
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FCBlitz
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4:56a, 4/23/20
I probably have this wrong so my feelings will not be hurt If someone does correct. It seems I remember 5 strains of COVID19. The five are as follows:

1.) Strain #1 - Seattle ( California
2.) Strain #2 - New York
3.) Strain #3 - Recent claim by Taiwan they isolated a strain.
4.) Strain #4 - Italy (Mediterranean) ?
5.) Strain #5 Not sure

Please feel free to correct the information above.

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Not a Bot
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In reply to FCBlitz • 5:17a, 4/23/20
AG
I think it depends on what qualifies as a "strain." The Arizona strain seems to be genetically the most wildly different.
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culdeus
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In reply to FCBlitz • 9:16a, 4/23/20
AG
FCBlitz said:
I probably have this wrong so my feelings will not be hurt If someone does correct.
This type of information is best conveyed by someone that has a PHD.
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brownbrick
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9:34a, 4/23/20
AG
The more weakening mutations the better. Bring on the mutations 'Rona.
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BusterAg
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In reply to culdeus • 10:47a, 4/24/20
AG
culdeus said:
FCBlitz said:
I probably have this wrong so my feelings will not be hurt If someone does correct.
This type of information is best conveyed by someone that has a PHD.
I know a bunch of PhD's that are idiots.

I also know a bunch of them that are incredibly biased.

Those letters mean very little to me anymore unless you demonstrate some competence in the subject you are discussing.
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