I read an article saying that vaccines are currently being developed and that there will most likely be "multiple winners". The article emphasized that this is a good thing for global production.

My question is: if multiple vaccines are being used, won't this make covid19 more susceptible to mutate and essentially compounding the effect over time?

I believe this as well.

I think it's probably in our best interest to find an immune boosting vaccine and a good therapeutic.

You might be able to have this hammered out by this summer and have it circulating this fall.

amercer said:

---

We have never thrown the kind of resources at a vaccine campaign as we are right now. Generally it takes so long to get a vaccine because every step along the way is a financial go/no go point. That's all out the window now. Scaling up manufacturing for every candidate before efficacy is seen means tens of billions of dollars are being set on fire. It also means that we will probably have a vaccine in record time.

As for the OPs question, the manufacturing and formulations will be different between all the vaccines, but the actual viral protein that gets presented to your immune system will probably be very similar in all of them. Also this virus has a fairly low mutation rate, so escape seems less likely than with something like HIV.

---

Time will tell.

But if there is not another wave on an equal or greater scale to 2020, that funding will dry up rapidly and the biggest hurdle, distribution, will not be possible.

Everyone is charitable when the spotlight shows their actions. If the spotlight dims, so will the enthusiasm. That is true for all R&D projects.

I agree that in general the biggest problem with infectious disease research is that unless there is a pandemic nobody gives a ****. That's the real reason we don't have a SARS vaccine.

This time is a little different however. The public health campaign has been so effective that many people, as well as states and whole countries have said they aren't going back to normal until a vaccine is available. That will keep the money flowing for this.

Hell, the losses from canceling the NFL season would pay for ten vaccines by itself...

I've heard that no coronavirus has ever had a vaccine ... However, has anyone really put a ton of money into even trying to find one? I know they did for SARS but stopped pursuing it when SARS went away and there was no need for it (i.e. no customers)

Just curious because I see people use that as an argument that we won't have a successful vaccine or even one that helps. I have no idea if they have ever tried hard to create a coronavirus vaccine or not.

If we do not have a huge second wave on the scale of 2x flu deaths, do you think the American public will really care about Covid in 24 months? We will be going through a presidential election cycle, and SNL and late night tv will completely placate and shift onto something new and shiny.

The stats coming in on this thing worldwide are looking less and less terrifying and 1-2 semi successful treatments will end the panic that still remains.

As mentioned there is strong evidence old, extremely cheap vaccines may be providing useful responses. Much of the underdeveloped world is using these vaccines and it would make more logistical sense to adapt to their tactics than bringing something new online to selling them on the idea.

The money to develop a vaccine is minuscule compared to gaining the cooperation of the global community to distribute a vaccine among a significant portion of the population.

Not even counting the fact it could simply be a flu shot that varies year to year and only 45% or so of Americans bother to get it.

That has nothing to do with my question. My point is people are saying we might not get a good vaccine because no vaccine has ever been made for a coronavirus.

My question is simply, has anyone really ever tried with full resources to make a coronavirus vaccine.

I'm not making any sort of controversial statement, simply asking a question if it has really been efforted before. I truly don't know whether it has or not.

I hate that we can't ask questions without people thinking you have ulterior motives with the question.

Yes, we have tried. No, we haven't been successful. Yes, tons of money has been dumped into it. No, the demand has not kept the population interested in large scale distribution even if one was created.

Once a treatment is developed it largely removes all the incentive to produce and distribute a vaccine on an annual basis. So even if the whole world is dedicated to a vaccine a treatment would be easier to implement and distribute. Which is why the common cold (largely coronavirus) have never justified a vaccine.

Quote:

---

If we do not have a huge second wave on the scale of 2x flu deaths, do you think the American public will really care about Covid in 24 months?

---

if it's still ****ing with schools being fully online, then yes

WestGalvestonAggie said:

---

---

I knew that was Geddy Lee on the left!

We may get one...we may not.

But right now it is a world wide Space Race x Manhattan Project kind of thing.

Marcus Aurelius said:

---

Like HIV, there is unprecedented research/resources being thrown at this. I remember back in the HIV scare thinking there will never be a "cure" for it. Look where we are now with HIV. I pray the same will happen with this virus. Will it be a smallpox type eradication? No. I suspect the vaccine(s) will attenuate the infection like flu. Drug therapies will advance. Coronavirus research in the past has not been near close to the volume being performed now. Huge difference.

---

Look where we are now with HIV as in 40 years later and still no vaccine?

There are vaccines for animal coronaviruses. If we can develop coronavirus vaccines to protect swine and dogs I don't think it is unreasonable to hope that a coronavirus vaccine can be created for humans.

Marcus Aurelius said:

---

Absolutely. As far as the research response.

---

Sorry if I have missed it, but where do you practice medicine?

f burg ag said:

---

Marcus Aurelius said:

---

Absolutely. As far as the research response.

---

Sorry if I have missed it, but where do you practice medicine?

---

Bham, AL metro. But 89' Aggie, UTSW Parkland med school residency then Vandy fellowship for pulm CC sleep.

https://www.google.com/amp/s/www.nytimes.com/2020/05/15/us/politics/coronavirus-vaccine-timeline.amp.html

[We don't want the disrespectful comments. Take a break. - Staff]

AggieJosh2002 said:

---

I've heard that no coronavirus has ever had a vaccine ... However, has anyone really put a ton of money into even trying to find one? I know they did for SARS but stopped pursuing it when SARS went away and there was no need for it (i.e. no customers)

Just curious because I see people use that as an argument that we won't have a successful vaccine or even one that helps. I have no idea if they have ever tried hard to create a coronavirus vaccine or not.

---

Corona virus causes SARS (severe acute respiratory syndrome). One is a virus the other is an illness.

So it's like saying we haven't tried to make a vaccine for Rhino Virus but we have for Cold.