Estimating the burden of SARS-CoV-2 in France

1,703 Views | 8 Replies | Last: 5 yr ago by plain_o_llama
cone
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AG
https://science.sciencemag.org/content/early/2020/05/12/science.abc3517

Quote:

Abstract

France has been heavily affected by the SARS-CoV-2 epidemic and went into lockdown on the 17 March 2020. Using models applied to hospital and death data, we estimate the impact of the lockdown and current population immunity. We find 3.6% of infected individuals are hospitalized and 0.7% die, ranging from 0.001% in those <20 years of age (ya) to 10.1% in those >80ya. Across all ages, men are more likely to be hospitalized, enter intensive care, and die than women. The lockdown reduced the reproductive number from 2.90 to 0.67 (77% reduction). By 11 May 2020, when interventions are scheduled to be eased, we project 2.8 million (range: 1.84.7) people, or 4.4% (range: 2.87.2) of the population, will have been infected. Population immunity appears insufficient to avoid a second wave if all control measures are released at the end of the lockdown.




I don't know how you look at this data and continue blanket stay-at-homes. all of the HC resource utilization and death is within a very very specific group of the population.

it's both hopeful and depressing. we know who to protect, but for whatever reason we either don't have the capacity or the will to target that protection.
cone
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AG
here's the link to all the data in the charts:

https://science.sciencemag.org/content/sci/suppl/2020/05/12/science.abc3517.DC1/abc3517_Salje_SM.pdf
culdeus
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AG
Why does the probability of ICU drop as you get to the tail? Do they just move them off to hospice in that situation?
Pasquale Liucci
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AG
Very interesting data, thanks for sharing. Agreed with your premise that, based on this data, our strategy needs serious revision.
Joe Exotic
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AG
So basically ending lockdowns early will result in a second wave. However, that won't matter because this disease in France is essentially harmless if you aren't 80.

That's what I'm getting from those numbers.
Ranger222
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Reproduction number dropped from 2.9 to 0.6 -- lockdown worked exactly as intended.

cone
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AG
lockdowns help mitigate spread but as a blanket approach they are economically catastrophic

note that this data is just broken out for age cohort

i'm sure comorbidities play more predominant roles in the lower age cohort hospitalizations

theoretically, you could risk rank populations and attempt to cordon the riskiest off while having the active populations resume economic activity and still take the bug seriously to try and keep the R0 low (masking, non large events, mild social distancing). if we have the will to take on such a project seems to be another matter.

but the level of paranoia for people under the age of 60, not diabetic, not hypertensive, and not BMI > 35 (and sad to also say, with sufficient Vitamin D levels) is completely unjustified
GAC06
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AG
I don't fault the initial lockdown given what we saw in Italy, and not knowing a lot about the virus.

However now we know a lot more. People under 70 are basically not at risk from this virus according to that study. People still making decisions like shutting universities in the fall are borderline criminal at this point.
Fitch
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AG
Honestly that looks fairly consistent with the early data out of S. Korea.

From March 24th:
plain_o_llama
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I agree for the most part. I've been puzzling over how an individual's response matters to the whole.

This situation has reminded me the degree to which people differ. Everyone is analyzing the situation. For some like me that has meant studying statistics, looking at research findings, etc. For others their analysis is watching and reacting to what others are doing. Both approaches have strengths and weaknesses.

So where you can point to data and a perceived lack of rational response, many are paying little attention to data.

Even among politicians strategies vary. Congress critters get re-elected if they avoid going to jail or pissing off the wrong people. Following the crowd is a quite successful strategy. Leadership for them right now has little upside. The President, Governors, and some local officials for the most part have to lead, make choices, and face the consequences. They have to walk a tightrope between what they see as the data case and where the herd is headed while taking fire from all sides.
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