Docs - any experience with this test by W.H.P.M.

2,024 Views | 11 Replies | Last: 5 yr ago by BiochemAg97
Big Al 1992
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4:33p, 6/16/20
AG
Thoughts - we had this test done. Negative for active virus and negative for antibodies. Company is in California with a good reputation. Just seemed too easy - blood stick and result in 30 minutes.

https://www.cardinalhealth.com/content/dam/corp/web/documents/brochure/cardinal-health-covisure-patient-guidance.pdf
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Big Al 1992
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2:34p, 6/17/20
AG
Anyone?
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BiochemAg97
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3:15p, 6/17/20
AG
The info you linked is just an antibody test. It doesn't test for the presence of virus.

Since it tests for IgM and IgG and IgM can show up within 7 days of an infection while IgG shows up much later, you could infer an active infection if you were IgM positive and IgG negative. But it does not directly test for the virus. You can also infer an old long ago infection if IgM negative and IgG positive, but there is an area in between of IgM positive and IgG positive that can be either active or past infection.

Also, due the to guidance on antibody tests, the test has not been reviewed by the FDA. I think the FDA may have changed that guidance and at least wanted them to report accuracy data. Not really that important because they have this info on their website. "The clinical sensitivity is 93.5% and clinical specificity is 100% when compared to RT-PCR. The relative accuracy rate is 97.9%." https://www.whpm.com/covid-19
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BiochemAg97
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In reply to Big Al 1992 • 3:30p, 6/17/20
AG
Entirely possible they did a separate virus test. Abbott has one that is 15 min isothermal PCR. There were some questions about its accuracy a few weeks back, but Abbott said it was sample handling (putting the swab in a buffer rather than going directly into the machine).
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Big Al 1992
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3:52p, 6/17/20
AG
Thanks!! Got it - this shows I'm negative for active - so you could still have the virus and were just tested too early?


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BiochemAg97
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In reply to Big Al 1992 • 4:34p, 6/17/20
AG
Big Al 1992 said:
Thanks!! Got it - this shows I'm negative for active - so you could still have the virus and were just tested too early?


Yes. In other diseases, they have shown IgM takes about a week to come up. I have seen suggestions of 2 weeks after exposure before you should test for antibodies. Not sure what that is based on.

The RT-PCR test should show positive sooner, but there has been some suggestions of people who test negative for longer than expected.
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AggieFactor
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In reply to BiochemAg97 • 4:57p, 6/17/20
AG
Doc said the same thing to me which is why I have to wait a week for antibody test. She said that at 7 days or ~1-2 days after symptoms appear, the amount of antibodies in the system are only enough to produce around a 70% positive clip. If you can push that back to 14 days or ~8-9 days after the onset of symptoms, those results are over 99% accurate.
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RandyAg98
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In reply to Big Al 1992 • 5:11p, 6/17/20
AG
Big Al 1992 said:
Thanks!! Got it - this shows I'm negative for active - so you could still have the virus and were just tested too early?


Black Lives Matter has even infiltrated COVID testing?
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In reply to Big Al 1992 • 5:31p, 6/17/20
BiochemAg97
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In reply to [removed post] • 9:50p, 6/17/20
AG
AstroAg17 said:
Big Al 1992 said:
Thanks!! Got it - this shows I'm negative for active - so you could still have the virus and were just tested too early?


IgM and IgG are both types of antibodies. IgM appear earlier and fade earlier. IgG takes longer to show up but stays long term.

I agree the wording is confusing. "active IgM and antibodies IgG" is a super weird phrasing. They're both antibodies. IgM can be indicative of an active infection but there is still a lag time. Your negative IgM doesn't mean you don't have coronavirus.
I'll add that IgM tends to fade about a month or so after it shows up and it is possible to recover and be virus free before then. Thus IgM can be Indicative of an active infection, but it could be the result of a recently recovered infection.
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In reply to BiochemAg97 • 11:19p, 6/17/20
Big Al 1992
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2:50p, 6/25/20
AG
And is there still debate if you test positive for IgG after infection how long you are immune for? Dr. Rev mentioned studies that if you were asymptomatic, your antibodies might not be as strong, correct?
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BiochemAg97
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In reply to Big Al 1992 • 5:12p, 6/25/20
AG
Big Al 1992 said:
And is there still debate if you test positive for IgG after infection how long you are immune for? Dr. Rev mentioned studies that if you were asymptomatic, your antibodies might not be as strong, correct?
The study showed that asymptomatic is not as strong an immune response (lower antibody levels) and they end up being undetectable sooner (80% of the test subjects were not detectable after 3 months).

However, there is also some reason you didn't get sick, and your body would still remember how to make the antibodies. Production of antibodies the second time is much faster.

There is a big gap from "can't detect antibodies" to "no longer immune". Also repeated exposures tend to magnify the immune response. This is why some vaccines require multiple doses a month or more apart and why some vaccines require boosters periodically.
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