Using more convalescent plasma?

2,271 Views | 19 Replies | Last: 5 yr ago by SoulSlaveAG2005
chris1515
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With the news of hospital beds getting filled up, is there an increased use of convalescent plasma to get people recovered and well enough to leave?

Or is that not the silver bullet?
oldyella
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[See post below. - Staff]
TxAG#2011
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Take it to the politics board
Pasquale Liucci
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Consider this the SoulslaveAg signal. Haven't seen him post in a week or two. I know he works for a company that markets convalescent plasma and has had some good insight before
SoulSlaveAG2005
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Lester Freamon said:

Consider this the SoulslaveAg signal. Haven't seen him post in a week or two. I know he works for a company that markets convalescent plasma and has had some good insight before


I've been around. Lurking mostly, as work is crazy busy.

I do work for a community blood bank. And right now, all our focus is on 2 things. Restoring the red cell inventory and re-designing blood collection in a post COVID world, and how do we get more convalescent plasma donors.

On Tuesday of this week, we had a back order of 150 units of plasma. That is just for the DFW/central/East Texas service area.

Doctors are using plasma more often, and prescribing it quicker as they adapt. The majority of the plasma is being collected and transfused under the EAP through the Mayo Clinic.

They released preliminary results here recently.

https://www.uscovidplasma.org/safety-report

Initial results highlight the safety of the plasma program. Further study is being done one the efficacy of the plasma based on patient outcome, donor titers and other factors.

The docs I have contact with echo these same sentiments, it doesn't hurt them and a majority show immediate improvement after just 1 unit transfused.

I sat on a webinar yesterday from a small scale study (and I can't remember the hospital) but they said over 75% of patients improved within 2 hrs of transfusion or something like that. And that many EU countries are starting to give it earlier, even at the point of diagnosis.

We currently are struggling to meet local demand, and in order to fill the back orders had some shipped from NY blood center. Early on when our numbers were low, and we had excess inventory we shipped them some. And they kindly returned the favor this week.

Ideally, we would have these unicorns of blood donors lined up and donating. We can freeze the product for up to a year and our goal in coordination with HHS is to help build a "national stockpile" in case of another outbreak somewhere else's or here at home.

My ask right now for anyone is:
1) if healthy- give blood now at your local blood center. They need it. We are all struggling to meet patient demand for cancer treatments, heart surgeries and every day traumas.
2) if you are recovered from CV19. Sign up to donate convalescent plasma, almost all local centers are participating in the EAP program. It is helping, and it is desperately needed.


Thanks for sending the "vampire" bat signal. (Sorry, couldn't help myself on the pun)


ETA: no it's not a silver bullet, but it does seem to be helping based on doctor demand/Patient outcomes
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DCAggie13y
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SoulSlaveAG2005 said:

Lester Freamon said:

Consider this the SoulslaveAg signal. Haven't seen him post in a week or two. I know he works for a company that markets convalescent plasma and has had some good insight before


I've been around. Lurking mostly, as work is crazy busy.

I do work for a community blood bank. And right now, all our focus is on 2 things. Restoring the red cell inventory and re-designing blood collection in a post COVID world, and how do we get more convalescent plasma donors.

On Tuesday of this week, we had a back order of 150 units of plasma. That is just for the DFW/central/East Texas service area.

Doctors are using plasma more often, and prescribing it quicker as they adapt. The majority of the plasma is being collected and transfused under the EAP through the Mayo Clinic.

They released preliminary results here recently.

https://www.uscovidplasma.org/safety-report

Initial results highlight the safety of the plasma program. Further study is being done one the efficacy of the plasma based on patient outcome, donor titers and other factors.

The docs I have contact with echo these same sentiments, it doesn't hurt them and a majority show immediate improvement after just 1 unit transfused.

I sat on a webinar yesterday from a small scale study (and I can't remember the hospital) but they said over 75% of patients improved within 2 hrs of transfusion or something like that. And that many EU countries are starting to give it earlier, even at the point of diagnosis.

We currently are struggling to meet local demand, and in order to fill the back orders had some shipped from NY blood center. Early on when our numbers were low, and we had excess inventory we shipped them some. And they kindly returned the favor this week.

Ideally, we would have these unicorns of blood donors lined up and donating. We can freeze the product for up to a year and our goal in coordination with HHS is to help build a "national stockpile" in case of another outbreak somewhere else's or here at home.

My ask right now for anyone is:
1) if healthy- give blood now at your local blood center. They need it. We are all struggling to meet patient demand for cancer treatments, heart surgeries and every day traumas.
2) if you are recovered from CV19. Sign up to donate convalescent plasma, almost all local centers are participating in the EAP program. It is helping, and it is desperately needed.


Thanks for sending the "vampire" bat signal. (Sorry, couldn't help myself on the pun)


ETA: no it's not a silver bullet, but it does seem to be helping based on doctor demand/Patient outcomes


Should we donate even if we haven't tested positive for COVID?
Frisco
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Can you answer me something? I know I used to not be able to donate because I lived in Germany in in the early to mid 80's because of mad cow. I just tried to look it up and it seems that may have changed in April?
Pasquale Liucci
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Yes for sure
Pasquale Liucci
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Had read the same on the safety of the convalescent plasma efforts. I know we have a couple doctors on here who have attested to it's efficacy and have seen enough on Twitter to make me believe.

I actually signed up to give blood for the first time this week. Thanks for the info, always good to hear from the folks embedded in different parts of the front lines.
DCAggie13y
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Are they using play from people who don't have covid antibodies to treat covid patients?
eric76
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Gumby said:

SoulSlaveAG2005 said:

Lester Freamon said:

Consider this the SoulslaveAg signal. Haven't seen him post in a week or two. I know he works for a company that markets convalescent plasma and has had some good insight before


I've been around. Lurking mostly, as work is crazy busy.

I do work for a community blood bank. And right now, all our focus is on 2 things. Restoring the red cell inventory and re-designing blood collection in a post COVID world, and how do we get more convalescent plasma donors.

On Tuesday of this week, we had a back order of 150 units of plasma. That is just for the DFW/central/East Texas service area.

Doctors are using plasma more often, and prescribing it quicker as they adapt. The majority of the plasma is being collected and transfused under the EAP through the Mayo Clinic.

They released preliminary results here recently.

https://www.uscovidplasma.org/safety-report

Initial results highlight the safety of the plasma program. Further study is being done one the efficacy of the plasma based on patient outcome, donor titers and other factors.

The docs I have contact with echo these same sentiments, it doesn't hurt them and a majority show immediate improvement after just 1 unit transfused.

I sat on a webinar yesterday from a small scale study (and I can't remember the hospital) but they said over 75% of patients improved within 2 hrs of transfusion or something like that. And that many EU countries are starting to give it earlier, even at the point of diagnosis.

We currently are struggling to meet local demand, and in order to fill the back orders had some shipped from NY blood center. Early on when our numbers were low, and we had excess inventory we shipped them some. And they kindly returned the favor this week.

Ideally, we would have these unicorns of blood donors lined up and donating. We can freeze the product for up to a year and our goal in coordination with HHS is to help build a "national stockpile" in case of another outbreak somewhere else's or here at home.

My ask right now for anyone is:
1) if healthy- give blood now at your local blood center. They need it. We are all struggling to meet patient demand for cancer treatments, heart surgeries and every day traumas.
2) if you are recovered from CV19. Sign up to donate convalescent plasma, almost all local centers are participating in the EAP program. It is helping, and it is desperately needed.


Thanks for sending the "vampire" bat signal. (Sorry, couldn't help myself on the pun)


ETA: no it's not a silver bullet, but it does seem to be helping based on doctor demand/Patient outcomes


Should we donate even if we haven't tested positive for COVID?
They still need regular blood donations. From what I have been told, the covid-19 outbreak has resulted in fewer donations than usual.
Marcus Aurelius
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It works!! Saving lives. Rx 'd innumerable units. Amazing effects.
Not a Bot
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I have personally given a 300 pound uncontrolled diabetic African-American man on 6L nasal cannula (pretty much the main major risk factors) convalescent plasma. In April, this guy would've been put on a vent within a day and likely would not have made it.

I came back after a three day break to see he was no longer on the unit. I assumed he was in ICU. Turns out, he discharged home. Super nice guy, very worried family. I almost cried.

Since we've started giving it, our ICU upgrades have plummeted. Not a magic bullet by any means, but a very very valuable tool in the arsenal.

I'm hoping to see great results in the studies and have it be well publicized so that more people would be willing to donate.
SoulSlaveAG2005
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This is correct. Inventories are at historic lows, due to loss of blood drives. It's not just a local shortage it is national.

Thanks all who have given
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SoulSlaveAG2005
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Gumby said:

Are they using play from people who don't have covid antibodies to treat covid patients?


Not to my understanding. The premise behind convalescent plasma is that those recovered COVID patients plasma is antibody rich and helps confer passive immunity to the currently infected. Allowing their body time and a boost to help ramp up antibodies itself to beat back the virus.
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SoulSlaveAG2005
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Great story. Thx for sharing
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lazuras_dc
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Our local blood bank is checking all donations for COVID-19 ab's which is a cool perk. I'm signed up for an appointment to give platelets and plasma on Monday. I guess being AB+ my whole blood is worth about as much as muddy water.
SoulSlaveAG2005
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Lol.
Ya they need your plasma platelets.

You are the universal plasma donor. Ideal for MTP kits and always in short supply.

Fortunately you are also the universal recipient type for red cells, so AB+ red cels are not ever in high demand as AB+ patients can get anything offf the shelf.

We started doing antibody testing this past Monday as well.

Thanks for being a donor!
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SoulSlaveAG2005
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Frisco said:

Can you answer me something? I know I used to not be able to donate because I lived in Germany in in the early to mid 80's because of mad cow. I just tried to look it up and it seems that may have changed in April?


The fda did change the rules for Germany and Europe a travel in regards to Cvjd. We are currently finalizing SOP, IT, document, training and other processes so that we can meet the new fda guidance. Our goal was 6/30, but some other issues came up that diverted resources and it looks like a mid July finalization is expected.

Remember- if you were previously deferred, we MUST re admit you into the eligible donor base, and their is an FDA mandated process to do so.

If you had never been deferred before, then you can just start donating once everything is finalized.

Feel free to reach out if any more specific questions or if I can help in any other way
BowSowy
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Are y'all only collecting plasma from known COVID patients? I've been meaning to go donate some blood, and I definitely haven't had COVID symptoms (and doubt I have had COVID), so would my plasma not even be considered for plasma therapy?
SoulSlaveAG2005
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We are a full functional not for profit blood bank that collects whole blood, plasma, platelets, apheresis red cells for our hospital partners.

We are collecting just plasma from eligible and qualified recovered COVID 19 donors as convalescent plasma, as this tis the optimum blood component for us to collect from them.

Everyone else, we collect based on eligibility, and current inventory needs and donor willingness to provide.

You are correct. Your plasma would not be considered as convalescent plasma as you have not had COVID 19. However, your plasma can still be used for multitude of other treatments.

Thanks for being a donor.
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