Wow, if I'm reading this right, this is incredibly good news.

So....good news?

That's great, one key sentence in the study is compared to Oxford vaccine "our study showed early prevention of viral replication in the upper and lower airways after a high-dose challenge". Very encouraging,

Did the Oxford vaccine study not prevent the early replication?

From this paper about the Oxford study:
"these studies provided no evidence of a reduction of viral replication in nasal tissue, raising questions as to whether these vaccines could affect virus transmission."
First paragraph in discussion section

Is this the Moderna mRNA or a different manufacturer?

That's great and I'm glad someone published it! I'd still like to see a second animal model showing no VAERD

Aggie95 said:

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Is this the Moderna mRNA or a different manufacturer?

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That's a really good question..... this has routinely confused me because MRNA is the stock ticker for Moderna.

So I often don't know if I need to go check if it's swinging up because of good news, or if it's another company's mRNA trial.

tex2000 said:

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Can someone explain this as if I wasn't because I am not very smart?

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Fifm

This is the Moderna+NIH vaccine. Press release on the start of the Phase 3 here: https://www.nih.gov/news-events/news-releases/phase-3-clinical-trial-investigational-vaccine-covid-19-begins

anyone worried about long term autoimmune complications from the first ever mRNA vaccine?

Can't give an educated guess. Not sure mRNA would illicit more of this phenomenon than DNA or protein based vaccines. Depends on whether there is phylogenetic domain conservation between bat coronavirus S- spike mRNA and human. I doubt there is. I can tell you however this phenomenon does occur. As an example. Narcolepsy type 1. There is a protein sequence of ASO protein found on group A Streptococcus. The nucleotide sequence is phylogenetically similar to a group of neurons located in the posterior hypothalamus of human brain. This region of cells produces hypocretin - a neurotransmitter which surges between sleep / wake transmission.

Turns out - hypocretin is absent in families of dogs with narcolepsy. Due to a nonsense mutation in an exonic region of the gene. in human narcolepsy - no mutations have been found but CSF of these pts shows no hypocretin.

So, in Europe, after 2009 H1N1 GSK made a H1N1 vaccine and attached ASO to it to make it more immunogenic. After vaccination there was a sudden outbreak of type 1 narcolepsy in children. Further research has shown the ASO induced an autoimmune attack of the hypocretin secreting posterior hypothalamic cells, leading to cataplexy. Because of the phylogenetic code sequence as mentioned above.

So, remains to be seen with COVID.

first I remember hearing of the Moderna vacc at the 8:00 mark and after discussing the method he mentions the potential for an unforeseen autoimmune complication

Aggie95 said:

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Is this the Moderna mRNA or a different manufacturer?

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Moderna

The vaccine mRNA for the most antigenic region of the S spike region somehow enters the type 2 alveolar cell nuclei (a miraculous feat itself given they are injecting the vaccine into the monkey's trachea, and in the case of human vaccine - systemic injection.) The viral RNA is translated into S protein fragments (guessing) inducing the antibody production.

The key to the vaccine safety and the genius nature of this is it is just fragments of the S spike protein translated. Not the entire functional wicked SARS-COV-2 with its envelope, myriad of S spike proteins and of course its viscious nucleic acid core which attacks the human cells.

Fascinating. But - so "auto-immune" per se. But - I would be more concerned about conserved domains as I mentioned about to other human nucleotide sequences resembling the S spike protein.

Marcus Aurelius said:

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The vaccine mRNA for the most antigenic region of the S spike region somehow enters the type 2 alveolar cell nuclei (a miraculous feat itself given they are injecting the vaccine into the monkey's trachea, and in the case of human vaccine - systemic injection.) The viral RNA is translated into S protein fragments (guessing) inducing the antibody production.

The key to the vaccine safety and the genius nature of this is it is just fragments of the S spike protein translated. Not the entire functional wicked SARS-COV-2 with its envelope, myriad of S spike proteins and of course its viscious nucleic acid core which attacks the human cells.

Fascinating. But - so "auto-immune" per se. But - I would be more concerned about conserved domains as I mentioned about to other human nucleotide sequences resembling the S spike protein.

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This would be a great use for some fantastic deep learning models and a super computer. Not unlike hunting for off target mutations arising from gene editing.

Marcus Aurelius said:

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Can't give an educated guess. Not sure mRNA would illicit more of this phenomenon than DNA or protein based vaccines. Depends on whether there is phylogenetic domain conservation between bat coronavirus S- spike mRNA and human. I doubt there is. I can tell you however this phenomenon does occur. As an example. Narcolepsy type 1. There is a protein sequence of ASO protein found on group A Streptococcus. The nucleotide sequence is phylogenetically similar to a group of neurons located in the posterior hypothalamus of human brain. This region of cells produces hypocretin - a neurotransmitter which surges between sleep / wake transmission.

Turns out - hypocretin is absent in families of dogs with narcolepsy. Due to a nonsense mutation in an exonic region of the gene. in human narcolepsy - no mutations have been found but CSF of these pts shows no hypocretin.

So, in Europe, after 2009 H1N1 GSK made a H1N1 vaccine and attached ASO to it to make it more immunogenic. After vaccination there was a sudden outbreak of type 1 narcolepsy in children. Further research has shown the ASO induced an autoimmune attack of the hypocretin secreting posterior hypothalamic cells, leading to cataplexy. Because of the phylogenetic code sequence as mentioned above.

So, remains to be seen with COVID.

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Love the frequent (do you sleep btw???) updates. However am I the only one who reads this thinking dr Marcus is trying to dumb down an explanation and possible good news and I still feel like an idiot while reading it? I have a diploma from Texas A&M and I still don't understand the dumb down version. I'll post quotes below to show my ignorance.

phylogenetic domain conservation
posterior hypothalamus of human brain

exonic region of the gene

the ASO induced an autoimmune attack of the hypocretin secreting posterior hypothalamic cells, leading to cataplexy

^ I can't even start to attempt explaining that last one
Again thank you Dr Marcus

I am so impressed with this novel, and frankly genius, mechanism of vaccination I have gambled $10,000 on Moderna stock. And that is on a pediatrician's pay!

It has tremendous potential beyond COVID-19- talking about vaccine for cancers is a real possibility if you can get the right mRNA sequence to target malignant cells.

KidDoc said:

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I am so impressed with this novel, and frankly genius, mechanism of vaccination I have gambled $10,000 on Moderna stock. And that is on a pediatrician's pay!

It has tremendous potential beyond COVID-19- talking about vaccine for cancers is a real possibility if you can get the right mRNA sequence to target malignant cells.

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PFE is a much cheaper play than MRNA ...... but I see your low pediatrician pay and raise you one local PD patrol officer pay.

BTW.... look at what has happened to KODK of all companies yesterday.... based on one loan to manufacture vaccines.... KODAK!

VKint said:

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Conclusion:
Vaccination of nonhuman primates with mRNA-1273 induced robust SARS-CoV-2 neutralizing activity, rapid protection in the upper and lower airways, and no pathologic changes in the lung.
Translation:
Vaccine in monkeys gave good protective immune response in nose and lungs with nothing bad happening to lung tissues

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Thanks for dumbing it down for those who are not as intelligent as we are!