Mayo Clinic Preprint: Other Vaccinations Seem to Offer COVID Protection

2,794 Views | 16 Replies | Last: 5 yr ago by BBQ4Me
Keegan99
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7:40a, 7/29/20
AG
There was a theory suggested a while back that countries with strong MMR vaccination programs were not experiencing outbreaks. Maybe there is something to it?

Quote:
Multiple clinical studies are ongoing to assess whether existing vaccines may afford protection against SARS-CoV-2 infection through trained immunity.

In this exploratory study, we analyze immunization records from 137,037 individuals who received SARS-CoV-2 PCR tests. We find that polio, Hemophilus influenzae type-B (HIB), measles-mumps-rubella (MMR), varicella, pneumococcal conjugate (PCV13), geriatric flu, and hepatitis A / hepatitis B (HepA-HepB) vaccines administered in the past 1, 2, and 5 years are associated with decreased SARS-CoV-2 infection rates, even after adjusting for geographic SARS-CoV-2 incidence and testing rates, demographics, comorbidities, and number of other vaccinations.

Furthermore, age, race/ethnicity, and blood group stratified analyses reveal significantly lower SARS-CoV-2 rate among black individuals who have taken the PCV13 vaccine, with relative risk of 0.45 at the 5 year time horizon (n: 653, 95% CI: (0.32, 0.64), p-value: 6.9e-05). These findings suggest that additional pre-clinical and clinical studies are warranted to assess the protective effects of existing non-COVID-19 vaccines and explore underlying immunologic mechanisms. We note that the findings in this study are preliminary and are subject to change as more data becomes available and as further analysis is conducted.


Paper:

https://t.co/7XLCguml9a?amp=1
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AggieSarah01
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9:42a, 7/29/20
AG
Which would also explain how kids are much less affected by it!
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Complete Idiot
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9:50a, 7/29/20
I had shingles last year - I wonder if that helps me.

BRB, going to harvest my kid's plasma.
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jenn96
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10:03a, 7/29/20
AG
This is really interesting to me. It seems clear that there's something else besides luck going on with contagiousness in different countries and populations. Probably a combination of Vitamin D, genetics, etc but vaccines seems like they could easily be part of it. Would be amazing if a vaccine as simple and common as MMR could make a difference.
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DrZ
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1:17p, 7/29/20
AG
American Samoa had a measles out break a few years ago and made an effort to give everyone a MMR vaccine regardless of age. Not only 0 deaths but 0 cases to date. Small sample size but still.
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Old RV Ag
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In reply to Keegan99 • 1:36p, 7/29/20
AG
Well, hit diggity dog if that's true. I never had the measles as a kid and of course never had a vaccine shot as they weren't around. Two years ago my doctor recommended - and gave me - an MMR shot.
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94chem
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2:15p, 7/29/20
This was floating around on here months ago. I've been wondering when we'd get more info. I know several people who've gotten MMR/MMRV shots in response to this info.
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Rubble
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In reply to DrZ • 3:37p, 7/29/20
AG
DrZ said:
American Samoa had a measles out break a few years ago and made an effort to give everyone a MMR vaccine regardless of age. Not only 0 deaths but 0 cases to date. Small sample size but still.

Started in Sept 2019, so it's still going on, but 0 COVID cases in a place where they have done extensive vaccinations is pretty telling IMHO.
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Keegan99
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3:52p, 7/29/20
AG
Thread from two months ago, FWIW.

https://texags.com/forums/84/topics/3114665/replies
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Ranger222
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4:26p, 7/29/20
AG
This has been posted and discussed multiple times.

It was suggested very early on. See:

https://apnews.com/ae72d066a2caa17de91be9a60e4934b9

Problems:

(1) The exact mechanism(s) on how live vaccines offer an immune benefit to other infections is not known and has not been studied. There is very old references to these observations with the oral polio vaccine, but were never further characterized or studied.

(2) Funding. Several people tried to organize trials of SARS-CoV-2 infection rates and COVID-19 disease developments in individuals who had recently been administered live vaccines, but it never got off the ground. I believe these trials are being discussed in some forms, but it takes university centers to sign on, organization and money.

https://science.sciencemag.org/content/368/6496/1187
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flyingaggie12
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11:28p, 7/29/20
AG
Can I just roll up to a Walgreens/
CVS and get one of these bad boys?
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flyingaggie12
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11:29p, 7/29/20
AG
Also, I feel like the military would be a great case study for this. Don't they get like 100 shots when they start boot camp?
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94chem
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11:38a, 7/30/20
Quote:
(1) The exact mechanism(s) on how live vaccines offer an immune benefit to other infections is not known and has not been studied. There is very old references to these observations with the oral polio vaccine, but were never further characterized or studied.
As a chemist, these statements always make me chuckle. As if the exact mechanism of anything is understood...

In general, you don't prove mechanisms; you disprove them.
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jenn96
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In reply to flyingaggie12 • 1:17p, 7/30/20
AG
flyingaggie12 said:
Also, I feel like the military would be a great case study for this. Don't they get like 100 shots when they start boot camp?
True but the military is also, generally speaking, going to be a young, physically fit population with ready access to medical care and regular screenings for medical conditions so they are not representative of the population as a whole even before immunizations.
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P.U.T.U
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In reply to flyingaggie12 • 1:32p, 7/30/20
AG
flyingaggie12 said:
Also, I feel like the military would be a great case study for this. Don't they get like 100 shots when they start boot camp?
I have a friend deployed to the middle east right now and their medic is making everyone take HCQ and zinc
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Ranger222
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In reply to 94chem • 1:54p, 7/30/20
AG
tell that to my grant reviewers.....

Still, even a hint at how this works is not understood at all. Even with how advanced the field of immunology has become.
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GAC06
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In reply to P.U.T.U • 2:50p, 7/30/20
AG
P.U.T.U said:
flyingaggie12 said:
Also, I feel like the military would be a great case study for this. Don't they get like 100 shots when they start boot camp?
I have a friend deployed to the middle east right now and their medic is making everyone take HCQ and zinc


Not unusual to have to take an anti malarial over there. We had to take doxycycline in Afghanistan. Not saying that's the reason.
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BBQ4Me
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In reply to flyingaggie12 • 3:38p, 7/30/20
AG
flyingaggie12 said:
Also, I feel like the military would be a great case study for this. Don't they get like 100 shots when they start boot camp?


This is annecdotal, but there was that large outbreak on the naval carrier
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