Tocilizumab failed double blind RCT

Dr. Not Yet Dr. Ag

Joined: Jun 15, 2013

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4:26p, 7/29/20

https://www.roche.com/media/releases/med-cor-2020-07-29.htm

Quote:
COVACTA trial did not meet its primary endpoint of improved clinical status in patients with COVID-19 associated pneumonia, or the key secondary endpoint of reduced patient mortality
The study is the first global, randomised, double-blind, placebo-controlled phase III trial investigating Actemra/RoActemra in this setting

Hopefully the data will be available soon to review, but this is unfortunate.

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Aggie95

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4:34p, 7/29/20

AG

Interesting...some docs on here have been desperate to find some to help patients.

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oragator

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4:37p, 7/29/20

I mentioned it before, only 1 in 5 medicines that make it to stage three testing ever get approved. So this is disappointing but isn't unexpected, it is a numbers game - throw enough solutions out there and something will work.

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texan12

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In reply to oragator • 5:01p, 7/29/20

oragator said:
I mentioned it before, only 1 in 5 medicines that make it to stage three testing ever get approved. So this is disappointing but isn't unexpected, it is a numbers game - throw enough solutions out there and something will work.

Doesn't the 'Right to Try' bill allow patients more room to continue using these trial drugs?

oragator

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In reply to texan12 • 7:59a, 7/30/20

Not sure, though I am sure there will be a number of ways they try to get things to market and give them a go.
But the larger point I was making was that even most of the drugs that look promising early on don't turn out to be effective. So there will probably be more of this before we find a good one.

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94chem

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11:35a, 7/30/20

I wonder if anyone has tried the St Jude's protocol for cytokine storm cases. I saw that methotrexate was also used in that trial. Rather than trying to deal with the IL-6 issue with single drugs, just hit the patient with all of them at them same time?