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Really interesting article and pretty easy to follow even for non-med
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Last: 5 yr ago by chris1515
https://www.the-scientist.com/news-opinion/is-a-bradykinin-storm-brewing-in-covid-19--67876
Another article about it.
Another article about it.
Interesting
will this have an impact on dr's prescribing ACE inhibitors for hypertension?
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Nice that there were two distinct scientific paths (computational/genomic and molecular) to establish the bradykinin pathway. I imagine the race is on for repurposing the already marketed drugs/candidates.
Also, don't show the football boards (from medium):
Also, don't show the football boards (from medium):
Quote:
The bradykinin hypothesis also extends to many of Covid-19's effects on the heart. About one in five hospitalized Covid-19 patients have damage to their hearts, even if they never had cardiac issues before. Some of this is likely due to the virus infecting the heart directly through its ACE2 receptors. But the RAS also controls aspects of cardiac contractions and blood pressure. According to the researchers, bradykinin storms could create arrhythmias and low blood pressure, which are often seen in Covid-19 patients.
I've been saying for months this really acts more like a vascular infection than a lung infection (like flu or RSV). Nice to see some data coming out supporting my medical instincts.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
Safe to say "it's just another version of the flu" is incorrect?KidDoc said:
I've been saying for months this really acts more like a vascular infection than a lung infection (like flu or RSV). Nice to see some data coming out supporting my medical instincts.
Yes it does not act like the flu at all as far as complications. Most deaths from the flu are secondary bacterial pneumonia from MRSA. Not so much with COVID it is more of a pneumonitis with ARDS- very different.wildcat08 said:Safe to say "it's just another version of the flu" is incorrect?KidDoc said:
I've been saying for months this really acts more like a vascular infection than a lung infection (like flu or RSV). Nice to see some data coming out supporting my medical instincts.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
Then would bromelain help? Time to drink pineapple cocktails.
Numerous aggie docs here have been saying Vitamin D helps, so at least some of this gibes up.
I was taking my Vitamin D while reading the following. :-p
Interestingly, Jacobson's team also suggests vitamin D as a potentially useful Covid-19 drug. The vitamin is involved in the RAS system and could prove helpful by reducing levels of another compound, known as REN. Again, this could stop potentially deadly bradykinin storms from forming. The researchers note that vitamin D has already been shown to help those with Covid-19. The vitamin is readily available over the counter, and around 20% of the population is deficient. If indeed the vitamin proves effective at reducing the severity of bradykinin storms, it could be an easy, relatively safe way to reduce the severity of the virus.
Interestingly, Jacobson's team also suggests vitamin D as a potentially useful Covid-19 drug. The vitamin is involved in the RAS system and could prove helpful by reducing levels of another compound, known as REN. Again, this could stop potentially deadly bradykinin storms from forming. The researchers note that vitamin D has already been shown to help those with Covid-19. The vitamin is readily available over the counter, and around 20% of the population is deficient. If indeed the vitamin proves effective at reducing the severity of bradykinin storms, it could be an easy, relatively safe way to reduce the severity of the virus.
That is a really interesting article.
I've said all along that one of the benefits of staying at home, and wearing a mask, and postponing getting infected for as long as possible is that every day the doctors are getting much much smarter on how to treat this disease. Articles like this make me think that was a correct line of thinking.
I've said all along that one of the benefits of staying at home, and wearing a mask, and postponing getting infected for as long as possible is that every day the doctors are getting much much smarter on how to treat this disease. Articles like this make me think that was a correct line of thinking.
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