This is the NIH / Moderna vaccine. mRNA vaccine encoding the virus S-spike protein. Robust humoral and cellular viral neutralizing results at higher dose. Well tolerated. Patient population > 55 y/o.
if you're 65+ the long-term autoimmune risk from the moderna route is low (cuz you're old). you take it as soon as available.
no ****ing way am I giving the moderna shot to my kids tho
Considering kids aren't at risk, I agree.
Kids contracting it is basically an immunization, since they develop some immunity without showing symptoms...no?
I'm not sure that is completely true (although I could be wrong here). I think kids are less likely to get it due to the T Cell immunity they likely have from other Corona viruses. If they lack these, they likely have symptoms. But, this virus is far worse for elderly and obese, much more so than other pandemics. So, I think they are less likely to get it, but if they do, symptoms will be there, just not that severe.
Someone please correct me if I understand this wrong.
I'm 48 with obesity(mild not morbid) as a risk factor- I would get the Moderna shot today as part of the study if they asked especially if it meant I could go back to pre-COVID freedoms.
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This is the same report they issued at the end of August.
I have 5 family members who are in the Moderna study and have all apparently gotten the vaccine as we have all had reactions after the 2nd dose.
Generally it was a 101ish type of fever for a night with associated body aches and chills and a pretty good headache for a day that tapers off after a couple of days.
Well worth the protection that this (hopefully) affords.
I'm going to Vegas in 3 weeks so it is nice timing.
effectively, we don't know the long-term effects of having mRNA re-program your cells to produce the antibody response (as opposed to the less experimental methods)
if you're old, i don't think this is a big deal. if you're young, i'd wait for a platform with more of a track record.
effectively, we don't know the long-term effects of having mRNA re-program your cells to produce the antibody response (as opposed to the less experimental methods)
if you're old, i don't think this is a big deal. if you're young, i'd wait for a platform with more of a track record.
My professional opinion is these vaccines will not be FDA approved for children, COVID is just too low risk for kids < 18 relative to any other virus and they don't spread it as well as they spread RSV, Flu, etc. Heck I think they should aim for 50+ honestly.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
This is the same report they issued at the end of August.
I have 5 family members who are in the Moderna study and have all apparently gotten the vaccine as we have all had reactions after the 2nd dose.
Generally it was a 101ish type of fever for a night with associated body aches and chills and a pretty good headache for a day that tapers off after a couple of days.
Well worth the protection that this (hopefully) affords.
I'm going to Vegas in 3 weeks so it is nice timing.
This one is specifically looking at an older population. The early Aug publication of the phase 1 results (which was the study done in April/May and announced by Fauci in May/June) was for a younger healthy population. The significant news here is that the older population is having a similar response, although I think they focused on the 100 dose and they were looking at 50 dose at one point, and the phase 1 included a 25, 100, and larger dose. (250?).
effectively, we don't know the long-term effects of having mRNA re-program your cells to produce the antibody response (as opposed to the less experimental methods)
if you're old, i don't think this is a big deal. if you're young, i'd wait for a platform with more of a track record.
mRNA doesn't reprogram your cells for the long term. Human cells do not have the enzymes to reverse translate mRNA into DNA and RNA cannot be incorporated into a genome. mRNA is also relatively short lived with no way for the cell to make more of the vaccine mRNA.
It enters the cells to cause the cells to produce the spike protein for a short period of time. The immune system is designed to recognize these cells producing the viral protein and destroy them. So, the "reprogrammed" cells are destroyed in the normal course of the response.
"less experimental methods" utilize viruses and generally avoid using viruses that insert material into your genome. Instead the virus can be used to provide material to your cells so the cells make the mRNA and then produce the viral proteins.
This method basically skips the middle step but the result of both mechanisms is the same with viral mRNA in the cell so the cell produces viral proteins.
effectively, we don't know the long-term effects of having mRNA re-program your cells to produce the antibody response (as opposed to the less experimental methods)
if you're old, i don't think this is a big deal. if you're young, i'd wait for a platform with more of a track record.
My professional opinion is these vaccines will not be FDA approved for children, COVID is just too low risk for kids < 18 relative to any other virus and they don't spread it as well as they spread RSV, Flu, etc. Heck I think they should aim for 50+ honestly.
I don't believe they have included children in any of the studies yet. And I agree, there just isn't much value for health children. Low risk from disease and if adults are vaccinated, they aren't going to catch it at school and spread it to the adults or spread it to teachers.
Typically, the studies start with healthy adults, then after positive results in health adults move into older or younger patients to confirm dosage and effectiveness in that population. We see in the OP where they are specifically including older people in studies.
Also, if you look at the CDC's rollout guidelines, it starts with high risk patients and doesn't get to the general healthy adult population until phase 4. I could see use for a high risk child but you would be unlikely to get vaccine for healthy children until well into next year after it is widely available to adults. To the extent that FDA and manufactures think vaccination of children is warranted, there would be plenty of time to do a study of effectiveness and safety on children.
