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Abstract

Four different endemic coronaviruses (eCoVs) are etiologic agents for the seasonal "common cold," and these eCoVs share extensive sequence homology with human severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we show that individuals with as compared to without a relatively recent documented eCoV were tested at greater frequency for respiratory infections but had similar rate of SARS-CoV-2 acquisition. Importantly, the patients with a previously detected eCoV had less severe coronavirus disease-2019 (COVID-19) illness. Our observations suggest that pre-existing immune responses against endemic human coronaviruses can mitigate disease manifestations from SARS-CoV-2 infection.

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Bruce Almighty said:

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Isn't that a theory as to why kids are so much better at getting rid of it?

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Keegan99 said:

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Bruce Almighty said:

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Isn't that a theory as to why kids are so much better at getting rid of it?

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This may also hint at why adults with children - or those that spend a lot of time around children - seem to anecdotally be at less risk.

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Keegan99 said:

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Want milder COVID? It may be in your best interest to catch some colds.

Quote:

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Abstract

Four different endemic coronaviruses (eCoVs) are etiologic agents for the seasonal "common cold," and these eCoVs share extensive sequence homology with human severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we show that individuals with as compared to without a relatively recent documented eCoV were tested at greater frequency for respiratory infections but had similar rate of SARS-CoV-2 acquisition. Importantly, the patients with a previously detected eCoV had less severe coronavirus disease-2019 (COVID-19) illness. Our observations suggest that pre-existing immune responses against endemic human coronaviruses can mitigate disease manifestations from SARS-CoV-2 infection.

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https://www.jci.org/articles/view/143380/pdf

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