No, according to my Dr. I just had fever end after 12 days (this past Thursday). Only symptom I had after day 8 (headaches was only other symptom besides some fatigue). Fever was on and off and mainly 99.3 to 100.6 ish and 3 nights where it hit 101.1 or so. It would go away and I thought i would be done and it would come back. That was frustrating. Anyways, it went away Thursday evening (day 12)and that was it.