My wife and I have been holding off on trying for our second kid til everything settles down. Would like to wait for the vaccine to become more prevalent. She's type 1 diabetic so we're trying to get going ASAP. I know it's not advised for pregnant women to receive the vaccine but is it advisable for her to get it before we start trying?

There's no data available to know. Pregnant women were specifically excluded from the trials nor was it recommended to become pregnant while enrolled.

My wife was offered the vaccine by Methodist last week but decline since she is 6 months pregnant and there is no data to know. We will both get it in the spring (her before me probably since she is first line).

Jock 07 said:

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My wife and I have been holding off on trying for our second kid til everything settles down. Would like to wait for the vaccine to become more prevalent. She's type 1 diabetic so we're trying to get going ASAP. I know it's not advised for pregnant women to receive the vaccine but is it advisable for her to get it before we start trying?

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The current vaccines are two doses. Should be fine after side effects of the second dose subside. However, out of an abundance of caution, I would suggest waiting a month after the second dose.


In reality, it is not recommended for pregnant women because we don't have any data. As Forum Troll said, they were excluded from the trials. That is typical and precautionary. We don't have any data to suggest it is harmful to a pregnant mother or the fetus, but we don't have data showing it is safe either.

The biggest risk I can see for a pregnant mother is a fever spike. We know high temps during certain times in pregnancy can be bad for the baby. This is why a pregnant woman shouldn't spend a lot of time in hot tubs.

Right and that's my question. If she gets vaccinated and waits a month or two after the second shot and hasn't shown any side affects for a period of time could it still potentially affect the pregnancy. I know there isn't sufficient data available to make a call with a great amount of certainty. I guess the question boils down to would the effects be the same as a woman who was already pregnant getting the shot vs someone who had the shot a month or longer ago and then becomes pregnant.

Jock 07 said:

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Right and that's my question. If she gets vaccinated and waits a month or two after the second shot and hasn't shown any side affects for a period of time could it still potentially affect the pregnancy. I know there isn't sufficient data available to make a call with a great amount of certainty. I guess the question boils down to would the effects be the same as a woman who was already pregnant getting the shot vs someone who had the shot a month or longer ago and then becomes pregnant.

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I believe there would be very little to no risk if she got pregnant a month or so later.

Everything in the vaccine should be cleared from the body in a matter of days, a week or two at most. I don't know the exact ingredient list, and it will differ somewhat between Pfizer and Moderna and others, but I can't imagine they would put something in that doesn't have a reasonable clearance rate as it would surely raise a red flag with FDA.

BiochemAg97 said:

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Jock 07 said:

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Right and that's my question. If she gets vaccinated and waits a month or two after the second shot and hasn't shown any side affects for a period of time could it still potentially affect the pregnancy. I know there isn't sufficient data available to make a call with a great amount of certainty. I guess the question boils down to would the effects be the same as a woman who was already pregnant getting the shot vs someone who had the shot a month or longer ago and then becomes pregnant.

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I believe there would be very little to no risk if she got pregnant a month or so later.

Everything in the vaccine should be cleared from the body in a matter of days, a week or two at most. I don't know the exact ingredient list, and it will differ somewhat between Pfizer and Moderna and others, but I can't imagine they would put something in that doesn't have a reasonable clearance rate as it would surely raise a red flag with FDA.

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cool, thanks for that. that's in line with what I was thinking as well.

Polyethylene glycol is the ingredient they currently suspect for the allergic reactions. Looking at clearance rates (really high doses in rats) half of it was cleared in a week, although they monitored the rats for 12 weeks.

The authors of the paper noted that the clearance was dose dependent with lower doses being cleared faster. They also note that clinically relevant doses are much lower. The highest rat dose was 10,000 times higher (200 mg/kg) than the highest clinically relevant dose (0.002 mg/kg). And I would guess the amount in the 0.3ml vaccine dose is really small compared to an adult adult weight.

That supports my thinking that a month should clear most/all vaccine ingredients.

Jock 07 said:

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BiochemAg97 said:

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Jock 07 said:

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Right and that's my question. If she gets vaccinated and waits a month or two after the second shot and hasn't shown any side affects for a period of time could it still potentially affect the pregnancy. I know there isn't sufficient data available to make a call with a great amount of certainty. I guess the question boils down to would the effects be the same as a woman who was already pregnant getting the shot vs someone who had the shot a month or longer ago and then becomes pregnant.

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I believe there would be very little to no risk if she got pregnant a month or so later.

Everything in the vaccine should be cleared from the body in a matter of days, a week or two at most. I don't know the exact ingredient list, and it will differ somewhat between Pfizer and Moderna and others, but I can't imagine they would put something in that doesn't have a reasonable clearance rate as it would surely raise a red flag with FDA.

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cool, thanks for that. that's in line with what I was thinking as well.

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I'm in the same boat. I'll relay this to my wife as we are still trying to get pregnant. Her job is requiring her to get the vaccine to continue working, and pregnancy >>>>> any job right now.

She also has an appointment with a fertility doctor and OBGYN in about 2 weeks and we will know more then. Looks like we might need to stop trying until after the two shots.