This could be purely anecdotal, but I have now heard of two people who received their first dose of mRNA without knowing they were presymptomatic. Both had symptom onset within a day or two after getting their shots, and went on to have severe disease, one (healthy, 30s) has been on a ventilator for weeks, the other (healthy, 60s) did not survive.

Is this a known problem, or just a matter of consequence? It makes sense to me that vaccinating a presymptomatic person could be problematic, as the immune system is dealing with peak viral load and then could be overwhelmed by the vaccine induced response. I'm not medical so I have no idea, just wondering if this is a documented issue.

This exact scenario(being pre symptomatic at the first dose) happened to me and a couple other people that I know of. Only loss of smell, moderate headeaches and sleeping more than usual for about a week for me and nothing of note with the couple of other people I know about. There are going to be anomalies with anything in the world, and cases like those certainly sound like they might fit into the category of anomalous.

Good to hear! I was hoping this was purely anecdotal/anomalous, and not trying to fear monger, just wondering it had been an issue for others. Glad you had no problems.

Aggie95 said:

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if we were seeing this in any meaningful amounts, I think you would see recommendation of getting a covid test 2 or 3 day prior to getting your shot.

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This. My sister tested positive 2 days after her first shot. Minor sinus symptoms and was back to normal after a week