I've read people being skeptical of the mRNA, so was wondering if the Adenovirus vac is more "safe" than the others, or causes less worry/anxiety among those who get it? Basically looking for general info comparing the two types. Also, would adenovirus vac require booster, or is it too early to know?

I've actually been wondering the same. I read somewhere that the viral vector method has been used in past vaccines but not many. Other than the way the mRNA makes it into your cell, it's an almost identical method right?

I thought that the end result was the same - make some harmless spikes for immune system to learn to attack.

One issue with adenoviruses and their use as vectors to carry genetic material, both in the case of gene therapy applications where they are most commonly used, and in this case vaccination to carry the genetic material of the SARS-COV-2 spike protein, is that the body will recognize the adenovirus vector and mount an immune response to the vector itself since its foreign. The beauty and benefit of mRNA vaccines is that they don't require this extra delivery packaging and the genetic material can be delivered straight to the cells and eliminates this issue.

Most of the issues surrounding adverse reactions/immune responses to adenovirus vectors have been worked out over the last 25+ years and are now quite safe, but I'd still opt for the simpler mRNA vaccine and not have to worry about potential effects from the adenovirus vector.

Captain Positivity said:

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The adenovirus vaccine works by genetically modifying an adenovirus. Once inside the cell, the adenovirus enters the nucleus and genetic instructions force the nucleus to manufacture mRNA for the covid spike protein. The mRNA leaves the nucleus, enters the ribosome where the proteins are produced. The proteins enter the bloodstream and the body counters with an immune response.

The mRNA vaccine contains the mRNA inside of a lipid. The lipid helps the mRNA get into your cells, where it enters the ribosome and produces the proteins. The mRNA vaccine is actually a simpler system.

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Dammit, beat me to it!