NE PA Ag said:
The big thing with me was the relatively new and unproven MRNA tech of the Pfizer and Moderna shots. I got the J&J since it was the old tech that was proven over many years, even though it supposedly had a lower efficacy. I would not have gotten an MRNA shot if it had been the only choice.
Now I wouldn't even get the J&J if I had it to do over again.
The J&J shot was not a traditional vaccine either. It's doesn't use mRNA but does use viral DNA transmitted by the adenovirus.
A traditional vaccine takes the real virus and kills it off. Your body gets to attack the real thing in a harmless state and builds up immunity. If you encounter the live virus later your body will be ready for it. If the virus in the vaccine is not completely disabled then you may get infected. That's an acceptable risk for the flu but not for something like HIV. So they came up with alternative approaches to simulate a vaccine without using the original virus by having your own cells produce a spike protein that matches the target virus.
Your cells naturally create proteins as instructed by mRNA generated by the cell itself. The mRNA vaccines hijack this process by introducing synthetic mRNA which instruct your cells to produce a spike protein that mimics Covid. Your body then attacks this protein and theoretically learns to attack the real virus in the future. They claim the synthetic mRNA will only be in the body for a short time and has no lasting impact. Some studies have shown this mRNA does persist and can make its way to the heart. Your body may also detect that these hijacked cells appear foreign, causing your immune system to destroy them. That's not a big deal for deltoid muscle cells but is a pretty big deal for brain or heart cells.
The J&J shot uses a genetically modified adenovirus that is not supposed to be able to replicate but does inject viral DNA into your cells. This programs your cells to produce the mRNA to instruct organelles to produce the spike protein. After that it's pretty much the same concept as the other vaccines.
All of these new vaccines manipulate your cells to unnaturally produce a foreign protein. Forcing your cells to behave unnaturally could have adverse effects that are not fully understood.
The Novavax may be a good approach. They use the same concept but they manipulate the cells in a moth and have it produce the protein. Then they collect that protein somehow and inject it into people. So the human cells are not altered in any way, humans only get exposed to the protein that was produced by the moth.
They could have developed a Covid vaccine like they do for the flu. It would have some risk but acceptable, like there is with the flu. I believed they forced this spike protein generation approach so they could do large scale experimentation with their new toy.