"Too well spoken"

Huh?

Aggie Therapist said:

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"Too well spoken"

Huh?

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Having spent a lot of time in that area for work it is very normal for a well educated person from the area to be very measured in their speech in public settings. Customers and researchers I dealt with were very concerned for not being taken serious because of their accent.

Aggie Therapist said:

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I'm all for treating Vets with non big pharna alternatives

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What makes you think this won't become big pharma?

Awww, so kind of like self-conscious so they almost over do it.

Aggie Therapist said:

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"Too well spoken"

Huh?

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smooth to the point of being a bit southern televangelist-ish. Not the fiery type but very rehearsed

Understood.

I can definitely see that.

the texas government selects people like dude phelan to run things. you think theyre going to do anything worth a ****?

They need it to come off schedule 1 first and foremost, and that call has nothing to do with texas

FIDO*98* said:

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Aggie Therapist said:

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Does anyone know Abbott's stance

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He'll stick his finger in the wind just like every other decision and come out on the side of donors. Will probably use the religious Right to kill it so the money keeps flowing.

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I would imagine that the more important person in the process is Dan Patrick.

Yep, when it comes to Texas specifically, Dan Patrick is the biggest obstacle

DannyDuberstein said:

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Yep, when it comes to Texas specifically, Dan Patrick is the biggest obstacle

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And if it's anything like how he feels about hemp, this will go nowhere

Aggie Therapist said:

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Awww, so kind of like self-conscious so they almost over do it.

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In my experience yes. I have a moderate southern accent and in academic settings I find myself speaking slower and using more measured/advanced vocabulary. I don't like being dismissed by folks from California before I even make my point.

My wife was at a talk once and pointed it out to me.

DannyDuberstein said:

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Aggie Therapist said:

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"Too well spoken"

Huh?

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smooth to the point of being a bit southern televangelist-ish. Not the fiery type but very rehearsed

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Watched this last night and I got more of that vibe from Rick Perry regarding all of this. It's a fascinating topic that I was completely unaware of but I just couldn't help but think Perry has to be in this for himself in some greater capacity.

I like Rick and perhaps I'm just cynical.

Agree. Jocko Willink has a recent podcast where he talks in depth about how normal it was to get "wasted" on booze in the Teams. He also explained how he drank much less alcohol as he progressed in his military career, and quit drinking a number of years ago. Hard to drink when you get up at 4:30am, run a business and podcast, and practice jujitsu.

I watched a colleague drink himself to death in a field where "everyone" went out to drink when we traveled. Ed was the last guy at the bar night after night and no one intervened.

I watched the entire episode. Kudos to Rick Perry for putting his reputation behind this. I am going to withhold my opinion of Andy Beshear, but will say those who label him a "moderate" democrat have no idea what they are talking about. I have seen some of the crap he has pulled in Kentucky and have no idea how he gets reelected.

Curious where Rand Paul stands on this.
Great podcast.
Love what Joe Rogan is doing to get information out there about something big pharma won't touch, is politically tough, and the media has not publicized.

2 things I need from Rick Perry after listening to the entire episode:

1. Please give Joe Rogan an Ole Sarge t-shirt. He needs one in place of the burnt orange crap he wore in the Mike Rowe episode.

2. Ease up on the use of the word "literally". He must have used this crutch word 20x during this podcast.

Especially when you drop a vowel and say litrally

https://www.texastribune.org/2025/06/11/texas-psychedelics-ibogaine-treatment-addiction-rick-perry-funding/


Good job. Let the science work now and see what it tells us.

I know quite a bit about this subject:

1) Ibogaine is in a class of psychedelics that are similar to psilocybin (magic mushrooms), LSD, ayahuasca, and DMT. They create a serotonin bath for your brain that does two things: 1) creates hallucinations; and, more importantly, 2) helps your brain literally re-wire through neuroplasticity. David Eagleman and Jordon Peterson touch on psychedelics and neuroplasticity a bit, Dr. Eagleman is one of the world's most renowned neurologists. Huberman Labs goes over psychedelics and neuroplasticity very well too. These psychedelic medicines have shown tremendous promise in the recovery from addiction, depression, and PTSD. Johns Hopkins performed the most well know and impactful clinical trial, which has been replicated by entities such as the Mayo clinic, Berkely, and others. The data from these trials is amazing.

2) Ibogaine has one major advantage and one major drawback compared to other medicines in this class. For some reason, it greatly interrupts the body's opium withdrawal process, reducing the amount of time you are dope sick from something like a month to something like 3 to 4 days. That is a HUGE advantage, because being dope sick is one of the most difficult challenges of recovering from opioids like heroin and fentanyl. The disadvantage for Ibogaine is that it can cause blood pressure spikes, which can be dangerous, especially if the patient is going through alcohol withdrawal as well, which can exasperate blood pressure spikes.

3) Ibogaine is fairly new for medical treatment, so it is well positioned to be developed by big pharma. There is enough novelty that there is likely some intellectual property that can be attached to the drug so that generics will not be available for a decade or so after FDA approval. It is not something that you take as an ongoing therapy. It is a cure, not an ongoing treatment. Think of it as chemotherapy for brain mis-wiring diseases.

4) Getting Ibogaine through the FDA approval process will greatly facilitate the opportunity to have other psychedelics make it through the FDA process, and get off the Schedule I list. Pharma might be able to bribe the FDA into slowing things down, but, at some point, no politician wants to be the face of the political movement to ban drugs that are proven to help with PTSD and opioid addiction. Not everyone can take Ibogaine. Pretty much anyone can take psilocybin, LSD or DMT. They are chemically very safe, and not chemically addictive. You just have to have a babysitter with you to make sure you don't convince yourself that you are superman and can fly out of a window.

This is all fantastic news, and I am very thankful that Perry put some weight behind it. The bill that passed through the Texas legislature is a $ for $ match of up to $50 million for clinical trials on Ibogaine for pretty much any treatment. I will be following this closely and watching where the money goes. Hopefully the execution is as good as the planning.

Follow up:

Texas has passed an initiative and are the first to do so but DEA is pushing back

Bumping this one last time in hope people can see this data and discussion.

BusterAg said:

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I know quite a bit about this subject:

1) Ibogaine is in a class of psychedelics that are similar to psilocybin (magic mushrooms), LSD, ayahuasca, and DMT. They create a serotonin bath for your brain that does two things: 1) creates hallucinations; and, more importantly, 2) helps your brain literally re-wire through neuroplasticity. David Eagleman and Jordon Peterson touch on psychedelics and neuroplasticity a bit, Dr. Eagleman is one of the world's most renowned neurologists. Huberman Labs goes over psychedelics and neuroplasticity very well too. These psychedelic medicines have shown tremendous promise in the recovery from addiction, depression, and PTSD. Johns Hopkins performed the most well know and impactful clinical trial, which has been replicated by entities such as the Mayo clinic, Berkely, and others. The data from these trials is amazing.

2) Ibogaine has one major advantage and one major drawback compared to other medicines in this class. For some reason, it greatly interrupts the body's opium withdrawal process, reducing the amount of time you are dope sick from something like a month to something like 3 to 4 days. That is a HUGE advantage, because being dope sick is one of the most difficult challenges of recovering from opioids like heroin and fentanyl. The disadvantage for Ibogaine is that it can cause blood pressure spikes, which can be dangerous, especially if the patient is going through alcohol withdrawal as well, which can exasperate blood pressure spikes.

3) Ibogaine is fairly new for medical treatment, so it is well positioned to be developed by big pharma. There is enough novelty that there is likely some intellectual property that can be attached to the drug so that generics will not be available for a decade or so after FDA approval. It is not something that you take as an ongoing therapy. It is a cure, not an ongoing treatment. Think of it as chemotherapy for brain mis-wiring diseases.

4) Getting Ibogaine through the FDA approval process will greatly facilitate the opportunity to have other psychedelics make it through the FDA process, and get off the Schedule I list. Pharma might be able to bribe the FDA into slowing things down, but, at some point, no politician wants to be the face of the political movement to ban drugs that are proven to help with PTSD and opioid addiction. Not everyone can take Ibogaine. Pretty much anyone can take psilocybin, LSD or DMT. They are chemically very safe, and not chemically addictive. You just have to have a babysitter with you to make sure you don't convince yourself that you are superman and can fly out of a window.

This is all fantastic news, and I am very thankful that Perry put some weight behind it. The bill that passed through the Texas legislature is a $ for $ match of up to $50 million for clinical trials on Ibogaine for pretty much any treatment. I will be following this closely and watching where the money goes. Hopefully the execution is as good as the planning.

---

Should also note that unlike magic mushrooms, etc… ibogaine is not a recreational drug. The experience is said to be pretty damn awful but worth it in the end.

V8Aggie said:

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Should also note that unlike magic mushrooms, etc… ibogaine is not a recreational drug. The experience is said to be pretty damn awful but worth it in the end.

---

The hallucinogenic state caused by Ibogaine is the same physical change that your brain goes through on any typical psychedelic drug, including psylocibin, LSD, DMT. The brain gets a giant serotonin bath, and parts of your brain that do not normally talk to eachother in a regular state start to connect and react to eachother. The sense of "oneness with the universe" is clich, but the best way to describe the warm emotional feeling that a helpful trip can create.

To be fair, ayahuasca is supposed to be much more harsh, in that the physical digestive systems are often horrible.

But, not many people take ayahuasca for a fun Friday night, either.

Again, the other major side-effect of this drug CAN be huge blood pressure spikes, which have to be monitored.

BusterAg said:

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V8Aggie said:

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Should also note that unlike magic mushrooms, etc… ibogaine is not a recreational drug. The experience is said to be pretty damn awful but worth it in the end.

---

The hallucinogenic state caused by Ibogaine is the same physical change that your brain goes through on any typical psychedelic drug, including psylocibin, LSD, DMT. The brain gets a giant serotonin bath, and parts of your brain that do not normally talk to eachother in a regular state start to connect and react to eachother. The sense of "oneness with the universe" is clich, but the best way to describe the warm emotional feeling that a helpful trip can create.

To be fair, ayahuasca is supposed to be much more harsh, in that the physical digestive systems are often horrible.

But, not many people take ayahuasca for a fun Friday night, either.

Again, the other major side-effect of this drug CAN be huge blood pressure spikes, which have to be monitored.

---

I'm just stating what folks who have undergone the treatment have said. It's not something that is fun or that they'd want to do again unless necessary.

Just trying to get ahead of the folks that are going to screech about it being on the streets, blah blah blah.

Yes you should only take it while under direct physician supervision.

What kind of data is there on its effectiveness reversing the impacts from diseases such as Parkinson's, Alzheimer's and dementia?

V8Aggie said:

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BusterAg said:

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V8Aggie said:

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Should also note that unlike magic mushrooms, etc… ibogaine is not a recreational drug. The experience is said to be pretty damn awful but worth it in the end.

---

The hallucinogenic state caused by Ibogaine is the same physical change that your brain goes through on any typical psychedelic drug, including psylocibin, LSD, DMT. The brain gets a giant serotonin bath, and parts of your brain that do not normally talk to eachother in a regular state start to connect and react to eachother. The sense of "oneness with the universe" is clich, but the best way to describe the warm emotional feeling that a helpful trip can create.

To be fair, ayahuasca is supposed to be much more harsh, in that the physical digestive systems are often horrible.

But, not many people take ayahuasca for a fun Friday night, either.

Again, the other major side-effect of this drug CAN be huge blood pressure spikes, which have to be monitored.

---

I'm just stating what folks who have undergone the treatment have said. It's not something that is fun or that they'd want to do again unless necessary.

Just trying to get ahead of the folks that are going to screech about it being on the streets, blah blah blah.

Yes you should only take it while under direct physician supervision.

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I, mean, good point, this is not going to be a street drug in any way.

Why would you pay for something that is costs so much money to synthesize when psilocybin is so cheap, and mushrooms have fewer side-effects?

Goose06 said:

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What kind of data is there on its effectiveness reversing the impacts from diseases such as Parkinson's, Alzheimer's and dementia?

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Lots of experimental studies, no good data that I know of.

Serotonin baths facilitate neuroplasticity, which can help the brain start to re-route some of the functioning away from damaged parts of the brain to more healthy parts of the brain, so the theory is that they could reduce symptoms and prolong higher quality of life from people with these types of brain diseases.

We need more research in this area, too. Just another reason to get psychedelics off of schedule 1.