THC Linked to DNA Damage and More

11,439 Views | 99 Replies | Last: 16 days ago by SigAg6
samurai_science
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Looks like the Duke research found it leads to miscarriages and DNA damage. Bonus:.....see below, one of the autism genes....

TLDR? THC is not as safe as we thought.



" Cannabis is detrimental to sperm: even if they can fertilize, there can be DNA damage. Many miscarriages and (in the case of IVF) "day 3 crashes" which is when paternal DNA normally kicks in, are cannabis related."

" Duke also found that the specific genes THC alters in sperm overlap with genes linked to autism. One of those genes, called DLGAP2, helps brain cells communicate with each other. It was changed in cannabis users' sperm. When researchers bred THC-exposed male rats and checked their offspring, the same altered gene pattern showed up in the pups' brains. The damage crossed a generation."

samurai_science
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Just one of the many factors leading to lower birth rates and increased autism. Maybe other long term health issues we dont even know about. I wonder if this could be tracked in states that have lax laws against its use?
Rapier108
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Also known to damage young, still developing brains.

Probably why segments of society known to be heavy users from a young age have very poor impulse control and are prone to homicidal violence within a split second.
Infection_Ag11
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AG
THC is definitely not as benign as many will claim, but the claims in the OP are based largely on some pretty fringe research/data. And Huberman is really starting to venture down the path of quackery in general.

But more to the point, smoking and alcohol use have FAR more well documented detrimental effects to both pregnant women and male fertility than THC does and both remain legal.

Again, no matter how dangerous long term THC use is, it is inconceivable we will ever discover that long term alcohol and tobacco aren't FAR more dangerous.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
Infection_Ag11
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AG
samurai_science said:

Just one of the many factors leading to lower birth rates and increased autism. Maybe other long term health issues we dont even know about. I wonder if this could be tracked in states that have lax laws against its use?


Falling fertility rates are driven largely by one, obesity (by far the biggest factor and why fertility rates are dropping much faster in developed countries which have higher rates of obesity) and two, the ubiquitous exposure to plastics and some of their byproducts.

Everything else is such a distant factor behind those as to effectively be irrelevant.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
Dave Robicheaux
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AG
Infection_Ag11 said:

THC is definitely not as benign as many will claim, but the claims in the OP are based largely on some pretty fringe research/data. And Huberman is really starting to venture down the path of quackery in general.

But more to the point, smoking and alcohol use have FAR more well documented detrimental effects to both pregnant women and male fertility than THC does and both remain legal.

Again, no matter how dangerous long term THC use is, it is inconceivable we will ever discover that long term alcohol and tobacco aren't FAR more dangerous.


Your statements are contradictory, It was a board certified reproductive endocrinologist saying that. " it is one of the most moveable factors to increase fertility outcomes"
Davanji84
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AG
I should be good. No desire to father more children and modern medicine insured that I won't. Pass the joint please.
Infection_Ag11
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Dave Robicheaux said:

Infection_Ag11 said:

THC is definitely not as benign as many will claim, but the claims in the OP are based largely on some pretty fringe research/data. And Huberman is really starting to venture down the path of quackery in general.

But more to the point, smoking and alcohol use have FAR more well documented detrimental effects to both pregnant women and male fertility than THC does and both remain legal.

Again, no matter how dangerous long term THC use is, it is inconceivable we will ever discover that long term alcohol and tobacco aren't FAR more dangerous.


Your statements are contradictory, It was a board certified reproductive endocrinologist saying that.


There are board certified oncologists who claim the cure for cancer is being covered up by big pharma, board certified infectious disease doctors who claim chronic Lyme disease is the cause of all nebulous syndromes like chronic fatigue syndrome, and board certified urologists who claim all positive urine cultures require antibiotics. And on and on. Examples exist in every field.

95% of board certified cardiologists will tell you COVID was exponentially more dangerous to the heart for most patient populations than the COVID vaccine, and most on this board would say they are wrong.

So I guess I don't understand what your point is. And I'm not even saying it definitely isn't true. I'm simply saying her claims are not substantiated by quality data to the degree she is leading people to believe at this time.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
Tony Franklins Other Shoe
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AG
Does THC also contribute to peanut allergies?

Person Not Capable of Pregnancy
FriscoKid
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AG
Infection_Ag11 said:

samurai_science said:

Just one of the many factors leading to lower birth rates and increased autism. Maybe other long term health issues we dont even know about. I wonder if this could be tracked in states that have lax laws against its use?


Falling fertility rates are driven largely by one, obesity (by far the biggest factor and why fertility rates are dropping much faster in developed countries which have higher rates of obesity) and two, the ubiquitous exposure to plastics and some of their byproducts.

Everything else is such a distant factor behind those as to effectively be irrelevant.

Explain to me like I'm 5 doc. The rocket can't reach the moon because of fat?
Dave Robicheaux
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AG
Infection_Ag11 said:

Dave Robicheaux said:

Infection_Ag11 said:

THC is definitely not as benign as many will claim, but the claims in the OP are based largely on some pretty fringe research/data. And Huberman is really starting to venture down the path of quackery in general.

But more to the point, smoking and alcohol use have FAR more well documented detrimental effects to both pregnant women and male fertility than THC does and both remain legal.

Again, no matter how dangerous long term THC use is, it is inconceivable we will ever discover that long term alcohol and tobacco aren't FAR more dangerous.


Your statements are contradictory, It was a board certified reproductive endocrinologist saying that.


There are board certified oncologists who claim the cure for cancer is being covered up by big pharma, board certified infectious disease doctors who claim chronic Lyme disease is the cause of all nebulous syndromes like chronic fatigue syndrome, and board certified urologists who claim all positive urine cultures require antibiotics. And on and on. Examples exist in every field.

95% of board certified cardiologists will tell you COVID was exponentially more dangerous to the heart for most patient populations than the COVID vaccine, and most on this board would say they are wrong.

So I guess I don't understand what your point is. And I'm not even saying it definitely isn't true. I'm simply saying her claims are not substantiated by quality data to the degree she is leading people to believe at this time.



there is modest correlation, which is enough when it comes to fertilization. Easy to examine sperm motility/anatomy and embryo development, way more than linkage with Covid/covid vaccine with coagulation issues ( I believe) or rheumatologic issues ( really tough to correlate)

IMO. it is something, and with young people doing more and more THC, it should at least turn on a flashing light.

ShackelfordAg99
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Infection_Ag11 said:

samurai_science said:

Just one of the many factors leading to lower birth rates and increased autism. Maybe other long term health issues we dont even know about. I wonder if this could be tracked in states that have lax laws against its use?


Falling fertility rates are driven largely by one, obesity (by far the biggest factor and why fertility rates are dropping much faster in developed countries which have higher rates of obesity) and two, the ubiquitous exposure to plastics and some of their byproducts.

Everything else is such a distant factor behind those as to effectively be irrelevant.


Does women opting for kids at a later age make much difference in overall U.S. fertility rates?

Edited to add overall.
Dave Robicheaux
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ShackelfordAg99 said:

Infection_Ag11 said:

samurai_science said:

Just one of the many factors leading to lower birth rates and increased autism. Maybe other long term health issues we dont even know about. I wonder if this could be tracked in states that have lax laws against its use?


Falling fertility rates are driven largely by one, obesity (by far the biggest factor and why fertility rates are dropping much faster in developed countries which have higher rates of obesity) and two, the ubiquitous exposure to plastics and some of their byproducts.

Everything else is such a distant factor behind those as to effectively be irrelevant.


Does women opting for kids at a later age make much difference in fertility rates?



4% chance per month after age 40
jja79
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AG
I'm not a scientist nor have I completed a legitimate study but the only people I know with a worthless, unmotivated, under performing 25-35 year old hanging around the house have the same cause. Marijuana.
FriscoKid
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Infection_Ag11 said:

samurai_science said:

Just one of the many factors leading to lower birth rates and increased autism. Maybe other long term health issues we dont even know about. I wonder if this could be tracked in states that have lax laws against its use?


Falling fertility rates are driven largely by one, obesity (by far the biggest factor and why fertility rates are dropping much faster in developed countries which have higher rates of obesity) and two, the ubiquitous exposure to plastics and some of their byproducts.

Everything else is such a distant factor behind those as to effectively be irrelevant.

Fat girls get knocked up all the time. And, I'll put "micro-plastics" on the same level as global warming, acid rain, and polar bears going extinct.

Alcohol and tobacco are a real issue, but I'm not buying the leftist "micro-plastic" crap.
Davanji84
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jja79 said:

I'm not a scientist nor have I completed a legitimate study but the only people I know with a worthless, unmotivated, under performing 25-35 year old hanging around the house have the same cause. Marijuana.


And possibly enabling parents or spouses? Besides, how are they buying pot if they are just hanging at the house. In any case, kick their asses out and they'll get motivated in a hurry. Damn near guaranteed.
kb2001
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AG
The most pathetic line of argumentation that potheads engage in is "but alcohol is worse". If you aren't capable of defending it without comparisons to alcohol, then you've already lost.

I'm in favor of immediate reclassification to schedule II or III, and legalization on a state by state basis. At a minimum, the rescheduling needs to happen so it can really be studied. There is so much bad information coming from people who want to ban it and people who want to legalize it, that needs to end.
Infection_Ag11
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ShackelfordAg99 said:

Infection_Ag11 said:

samurai_science said:

Just one of the many factors leading to lower birth rates and increased autism. Maybe other long term health issues we dont even know about. I wonder if this could be tracked in states that have lax laws against its use?


Falling fertility rates are driven largely by one, obesity (by far the biggest factor and why fertility rates are dropping much faster in developed countries which have higher rates of obesity) and two, the ubiquitous exposure to plastics and some of their byproducts.

Everything else is such a distant factor behind those as to effectively be irrelevant.


Does women opting for kids at a later age make much difference in overall U.S. fertility rates?

Edited to add overall.


Sure, but most statistics and data on the topic age correct for this. Fertility rates are dropping across the board.
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ShaggySLC
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kb2001 said:

The most pathetic line of argumentation that potheads engage in is "but alcohol is worse". If you aren't capable of defending it without comparisons to alcohol, then you've already lost.

I'm in favor of immediate reclassification to schedule II or III, and legalization on a state by state basis. At a minimum, the rescheduling needs to happen so it can really be studied. There is so much bad information coming from people who want to ban it and people who want to legalize it, that needs to end.

One is legal and the other isn't. What the hell are you talking about? One has plenty of data and research and is legal. The other is scheduled as the same class as meth which restricts research. Plenty of people have defended it without comparison to alcohol, its all over the forum. The hypocrisy in comparison to alcohol is 100% an argument that should be had.

Lol, you just saying potheads shows you're not capable of discussion on the topic.
Old Sarge
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Alcohol, Pot/THC, Tobacco, etc. are not beneficial to the brain. Hard drugs are worse. Not really debatable.

Social stigmas exist with all of them, but less so with alcohol.

Long term/heavy use with any of these results with issues that can have significant health issues, hard drugs being the leader in this category. Not really debatable.

The real issue that I have witnessed in my life, is that alcohol does not necessarily lead to anything more than alcohol issues, which are bad, but a focused issue.

The real issue that I have witnessed is, due to the nature of being truly unregulated (no matter which State), is that MJ exposes users to other drugs that are unregulated/illegal due to the nature of distribution and becomes an easy gateway to the harder drugs that likely have an irreversible outcome to the negative effect.

When it gets down to it, it is largely a cultural discipline effect. I know lots of people that drink alcohol a bit to the excess, but never let it affect their familial or professional lives. Same with Pot. However, I have seen people get into a pipeline of help with alcohol to correct their ways. Differentially, I have seen people that liked Pot slide into the darker drugs with a lesser off ramp. I've seen both type users that can handle every day life just fine professionally.

As seeing both in the professional life, early in their careers, usually the one that is occasionally hungover seems to lessen the issue over time because of the pain of it. Not always. The one that gets stoned/high usually seems to feel like it does not affect them because of lack of hangover effect, defends their position because of the lack of pain and continues the use if not increasing it. Again, not always if they are career driven.

There is no solution other than choices that individuals make, that will affect them, their lives both personally and professionally.
"Green" is the new RED.
Infection_Ag11
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FriscoKid said:

Infection_Ag11 said:

samurai_science said:

Just one of the many factors leading to lower birth rates and increased autism. Maybe other long term health issues we dont even know about. I wonder if this could be tracked in states that have lax laws against its use?


Falling fertility rates are driven largely by one, obesity (by far the biggest factor and why fertility rates are dropping much faster in developed countries which have higher rates of obesity) and two, the ubiquitous exposure to plastics and some of their byproducts.

Everything else is such a distant factor behind those as to effectively be irrelevant.

Fat girls get knocked up all the time. And, I'll put "micro-plastics" on the same level as global warming, acid rain, and polar bears going extinct.

Alcohol and tobacco are a real issue, but I'm not buying the leftist "micro-plastic" crap.


The data on obesity and infertility/pregnancy complications is as extensive as it gets. Miscarriage rates and female BMI show a direct correlation in every study ever done on the matter, for example.

With respect to plastics, some of the claims particularly those around cancer do seem to be overstated based on what we currently know. But there is a significant amount of literature showing pretty notable effects on the ability to conceive based on measured levels of certain microplastics. And we know beyond much doubt they do impact hormone regulation above certain levels, so it only stands to reason they likely impact fertility.

Also, not sure why you'd label concerns over plastics "leftist". Especially since some of the loudest voices on the issue are coming from the right these days.
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deer corn
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Let every man choose his vice and way to die.

Are we free or not?
LarryLayman
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Wonder if Pfizer paid for the report?
jja79
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Davanji84 said:

jja79 said:

I'm not a scientist nor have I completed a legitimate study but the only people I know with a worthless, unmotivated, under performing 25-35 year old hanging around the house have the same cause. Marijuana.


And possibly enabling parents or spouses? Besides, how are they buying pot if they are just hanging at the house. In any case, kick their asses out and they'll get motivated in a hurry. Damn near guaranteed.


As I said I'm not a scientist nor have I completed a legitimate expirament so I don't know how stupid parents factor in. Just saying in my almost 70 years the only 25-35 year old losers hanging out with parents are potheads.
ts5641
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"No but dude, I just do it for medicinal purposes.."
Mr.Milkshake
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lol two pages and not a single person actually looked up the study. It was….24 men. They have zero causation, no idea if what they found represents "damage', or any idea if what they did find is passed to children.

Meta analysis of both smoking and alcohol have proved DNA fragmentation in Men. Meta analysis has not done so for cannabis.

If you're worrying about it, stop drinking, using tobacco, and consuming anything with microplastics. It'll be tough to live
MouthBQ98
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I'm generally pro adult usage.of intoxicants that are not excessively harmful or destructive in reasonable amounts and that are reasonably predictable in dosage and effect.

We understand alcohol well now, but are still learning about the much more complex effects of THC and related canniboids as their chemistry and biochemistry is more complex. We have refined the production of the drug and majorly increased the typical dosage over the last couple of decades and the effects of it short and long term are less predictable.

A major concern is some apparent psychological effects including a significant occurrence of schizophrenia associated with heavy usage in the more youthful population. The effects of use on the individual aren't reliably linear with the dosage because it isn't a simple matter of blood concentration as it is with alcohol. I'm not saying we should ban adult use, but rather that we should be more cautious with it before we declare it relatively harmless and be open about the negative consequences we do observe so people can make informed choices.
Im Gipper
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Are you saying marijuana isn't good for you????

I'm Gipper
Bayou City
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Didn't effect mine
Davanji84
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jja79 said:

Davanji84 said:

jja79 said:

I'm not a scientist nor have I completed a legitimate study but the only people I know with a worthless, unmotivated, under performing 25-35 year old hanging around the house have the same cause. Marijuana.


And possibly enabling parents or spouses? Besides, how are they buying pot if they are just hanging at the house. In any case, kick their asses out and they'll get motivated in a hurry. Damn near guaranteed.


As I said I'm not a scientist nor have I completed a legitimate expirament so I don't know how stupid parents factor in. Just saying in my almost 70 years the only 25-35 year old losers hanging out with parents are potheads.

Good morning jja79. I know what you are saying and I don't necessarily disagree. I was more commenting based on personal experience except replace weed with alcohol. What I described was the solution to that issue and I can assume that it might also apply to the pothead. Have a great day.
agsalaska
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So now it's time to trust the science!
94chem
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Samurai science better be careful, or he'll start making a case for publicly funded scientific research.
94chem,
That, sir, was the greatest post in the history of TexAgs. I salute you. -- Dough
TexasAGGIEinAR
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Bayou City said:

Didn't effect mine


Same here. Didn't use THC before we had our first. Began having gummies before our 2nd. They actually increased my drive for all the "attempts". She's now 5 and is healthy, happy and smart as a whip. I've continued to partake. Carry on.
Burpelson
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There always has to be a boogeyman and THC is it!!
Lathspell
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jja79 said:

Davanji84 said:

jja79 said:

I'm not a scientist nor have I completed a legitimate study but the only people I know with a worthless, unmotivated, under performing 25-35 year old hanging around the house have the same cause. Marijuana.


And possibly enabling parents or spouses? Besides, how are they buying pot if they are just hanging at the house. In any case, kick their asses out and they'll get motivated in a hurry. Damn near guaranteed.


As I said I'm not a scientist nor have I completed a legitimate expirament so I don't know how stupid parents factor in. Just saying in my almost 70 years the only 25-35 year old losers hanging out with parents are potheads.


Lol. Okay, Mr Anecdote. Well, I can tell you i know MANY Marijuana users who are very successful and very productive members of society. The majority of fellow students I knew, at A&M, would both smoke and drink.

As long as you arent getting baked the moment you wake up, and then just sit on the couch all day, it's not an issue.

And the "gateway drug" bull**** is when I know someone is completely ignorant about weed. Alcohol is so much more impactful on your life. Alcohol literally negatively affects you the next day, as well.
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