Looks like the Duke research found it leads to miscarriages and DNA damage. Bonus:.....see below, one of the autism genes....
TLDR? THC is not as safe as we thought.
" Cannabis is detrimental to sperm: even if they can fertilize, there can be DNA damage. Many miscarriages and (in the case of IVF) "day 3 crashes" which is when paternal DNA normally kicks in, are cannabis related."
" Duke also found that the specific genes THC alters in sperm overlap with genes linked to autism. One of those genes, called DLGAP2, helps brain cells communicate with each other. It was changed in cannabis users' sperm. When researchers bred THC-exposed male rats and checked their offspring, the same altered gene pattern showed up in the pups' brains. The damage crossed a generation."
TLDR? THC is not as safe as we thought.
Cannabis is detrimental to sperm: even if they can fertilize, there can be DNA damage. Many miscarriages and (in the case of IVF) “day 3 crashes” which is when paternal DNA normally kicks in, are cannabis related. Dr Natalie Crawford on the Huberman Lab podcast out now. pic.twitter.com/Vdp98K890f
— Andrew D. Huberman, Ph.D. (@hubermanlab) April 13, 2026
" Cannabis is detrimental to sperm: even if they can fertilize, there can be DNA damage. Many miscarriages and (in the case of IVF) "day 3 crashes" which is when paternal DNA normally kicks in, are cannabis related."
" Duke also found that the specific genes THC alters in sperm overlap with genes linked to autism. One of those genes, called DLGAP2, helps brain cells communicate with each other. It was changed in cannabis users' sperm. When researchers bred THC-exposed male rats and checked their offspring, the same altered gene pattern showed up in the pups' brains. The damage crossed a generation."