I prefer driving as well, but it's mainly because I'm cheap and flying with 3 kids doesn't jive with that. We drive to the Iowa farm every year and will be driving to Colorado Springs this summer.
Now that they're older, we can pretty much do 15 hours with minimal stops. I don't mind driving on freeways where I can just chill while the wife reads and the kids eff around in the back. What I hate are routes that take us through small towns and their BS speed limits and stop lights. One way my wife likes us to go when we go to Iowa is up through Broken Bow, OK, which if you've ever driven from Houston to Lufkin before the I-69 bypass of that chit hole Diboll (and soon to be Corrigan), it's just like that from Livingston all the way to Fort Smith, AR. Speed up, slow down, stop, speed up, slow down, speed up, get caught behind Bubba and Bobbie doing 53 on a 2 lane 70 mph road and no way to pass them, slow down, speed up, finally pass the slow asses, get yelled at by the wife for driving like a lunatic, slow down, stop...I hate that route and try my best to avoid it.