Agree with above. Avoid east Amarillo and Amarillo Blvd. Anything in the west Medical complex area should be fine, which is west of Coulter, as above. West of Coulter and south of I-40 would be fine, but all the hotels are north of I-40. Go figure. One exception would be the hotel at I-27 and Hollywood is newer and probably nice.
Most of Amarillo is safe, as long as you stay off the east side and east Amarillo Blvd at night. Anything from I-27 west should be okay most anytime, as long as you don't stray too far north of I-40.
Frankly, there are few neighborhoods I avoid at any time of day.
Tacos Garcia on Ross is worth a trip to the east side of town, as would be Coyote Bluff.
Wouldn't mind having you in the neighborhood here in Canyon, as BBH said. I would probably travel the southern route, anyway:
College Station-Temple-Highway 36 to Abilene, I-20 to Sweetwater, US84 to Lubbock, I-27 to Amarillo.
Google maps tells me it would be 31 miles further that way, but you avoid I-35 traffic and downtown Ft. Worth. Once past Denton, 287 is pretty good, open and fast. But you have to scrupulously obey the speed limit in all the little towns on the way.
[This message has been edited by CanyonAg77 (edited 8/7/2012 5:54p).]