I tend to run up 281 to an FM (Chilpitin Creek Rd)north of Alice, turn right for about 5 miles to 359. Then 359 through Skidmore and Tynan to 181 into Beeville, then onto 59 to Goliad and Alt. 77. Then Alt. 77 all the way to La Grange and then onto 159/237 through Round Top and onto 290 to Burton, and then 390 through Gay Hill and onto 36 through Somerville and then left of 60 through Snook and into CS.
This was the fastest way for a long time, don't know about now with all the new toll roads and such. But I will tell you this, it is the prettiest way and the least cops way. I have made it from McAllen to CS in right at 5 hours several times.
It is just the way I go due to habit.