As others have said, this is a very personal answer. Typically, you can get a larger house on a larger lot for less money the further you get away from downtown. This is really appealing to younger families who need more space, but is totally unnecessary for a single person or a couple with no kids. The desire to or not to commute also plays a huge role.
My experience: I moved to Houston in 2008 and built a house in a suburb. My average commute to work was about 60-90 minutes each way. I did that for about 9 years and then we moved into Houston. My commute now is about 15-20 minutes on a bad day. That means I am spending 1-2 hours less in a car EVERY day. It was a complete life changer for me and my family and we're very glad we did it. More time at home with the family, less eating out due to now having time to cook, less gas, no dreading of a commute, closer to entertainment and amenities, etc
The tradeoff is that I sold my house built in 2008 for $100/SF and bought a remodeled house built in 1962 for $200/SF. We lost 1000 SF, 1 Bedroom, 1.5 Bathrooms, 1 Study/Office, and the lot is half the size. However, the change in lifestyle, ease of access to everything, and great neighbors made it completely worth it.
That being said, once the kids are out of school, my wife and I will likely move to a few acres outside of town to gain some privacy and peace & quiet