WoMD said:

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dermdoc said:

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So basically the antibody can bind to a specific site and stop the virus from replicating.

And you could also attach different anti virals to the antibody to enhance binding and therefore efficacy against the virus.

So say you had a leech that if it attached itself to an animal, it could prevent that animal from reproducing. And then you could poison through the leech to not only stop it from reproducing but actually destroy it due to the affinity of the leech.

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Not dumbed down enough.

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Hey my nickname in med school was Special Ed(my first name is Ed). So I can dumb it down with the best of them.

Actually to really dumb it down we used to call it putting a condom on a rabbit. And you can attach a grenade to the condom.

They may have found the kryptonite to weaken/kill the "super" Coronavirus

BiochemAg97 said:

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They have a picture of a SARS antibody bound to a portion of the new virus. While that is cool, the awesomeness is a bit exaggerated.

We have known for over a month that mouse antibodies bind and block infection in vitro. We have had near atomic resolution structure of the spike protein since Feb. we know the areas we are targeting with various vaccines are well conserved and haven't changed in all the times we sequenced the virus.

It is possible that you could create a molecule that binds to this spot, but that may not actually be useful unless it prevents some function of the virus.

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Agree my friend. All they said was it could bind to the Coronavirus so I assume it stopped its replication.

And miss seeing you. Still remember the Michters single batch you gave to me.

God bless.

Thank you Redd...

TXCityAggie said:

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Will someone smarter than me please dumb it down?

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Antibodies directed towards SARS from previously infected patients appear to bind to SARS-CoV-2 as well. The implications are that 1) SARS survivors may be immune to this or have a significantly lessened disease course and 2) we can utilize this information in the creation of a vaccine.

The caveat is that we don't actually know if the binding to this site actually inhibits the virus in vivo.

Infection_Ag11 said:

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TXCityAggie said:

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Will someone smarter than me please dumb it down?

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Antibodies directed towards SARS from previously infected patients appear to bind to SARS-CoV-2 as well. The implications are that 1) SARS survivors may be immune to this or have a significantly lessened disease course and 2) we can utilize this information in the creation of a vaccine.

The caveat is that we don't actually know if the binding to this site actually inhibits the virus in vivo.

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I did good following until "in vivo".

Cuterebra said:

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Beating SARS-Cov-2...It's as easy as putting a condom on a rabbit!

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Obviously you are not from East Texas. You put a condom on a rabbit, it quits replicating.

Philip J Fry said:

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Infection_Ag11 said:

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TXCityAggie said:

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Will someone smarter than me please dumb it down?

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Antibodies directed towards SARS from previously infected patients appear to bind to SARS-CoV-2 as well. The implications are that 1) SARS survivors may be immune to this or have a significantly lessened disease course and 2) we can utilize this information in the creation of a vaccine.

The caveat is that we don't actually know if the binding to this site actually inhibits the virus in vivo.

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I did good following until "in vivo".

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Sorry, it means in the body. In vitro is in the lab.

WoMD said:

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dermdoc said:

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So basically the antibody can bind to a specific site and stop the virus from replicating.

And you could also attach different anti virals to the antibody to enhance binding and therefore efficacy against the virus.

So say you had a leech that if it attached itself to an animal, it could prevent that animal from reproducing. And then you could poison through the leech to not only stop it from reproducing but actually destroy it due to the affinity of the leech.

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Not dumbed down enough.

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A vaccine works by taking part of the virus or bacterium and injecting it into a person.Sometimes the whole thing, but only after it has been made non-functional. Why do this crazy thing? Because it won't make you sick since the virus or bacterium is made non-functional. OK, but why the **** do it even if it is non-functional? Because, your body detects non-functioning invasions just like functioning ones. [You are still not making this make sense]. When your body detects any invasion it starts to fight it in multiple ways and a very important one is to create "antibodies" that are the exact match (opposite structure) to part of the invading substance. These antibodies will stick to that part of the invading bodies. The other end of the antibody is like a GPS tracking device and your MONSTER MACRO.P.H.A.G.E.S track them down and eat the antibody and whatever it is sticking to. Infection is a meal and will be removed.

However, creating antibodies to fight new infections takes days. Sometimes that is too long.

Here comes the key: once your body makes antibodies they stick around for the next time some ******* infection comes along and they start their job immediately, That is how you get immunity. So a vaccine which did not make you sick, still created antibodies that will work on the fully functional infection.

Here is the even better part: sometimes the antibodies for one disease work for a different infection. This is what happens with the original small pox vaccine. People who got cow pox also got immunity to small pox!

This article is saying that the antibodies for the original SARS infection vaccine are working on CoVId19. If so we can just start using the SARS vaccine to gain immunity quickly.

Quote:

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These antibodies will stick to that part of the invading bodies. The other end of the antibody is like a GPS tracking device and your MONSTER MACRO.P.H.A.G.E.S track them down and eat the antibody and whatever it is sticking to. Infection is a meal and will be removed.

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I remember to this day watching that video of the macro****es attacking a foreign cell.

Pretty sure I read in multiple places that the sars vaccine actually made people have a more severe immune response to SARS.

I don't know anything but the killer part of this seems to be the overwhelming immune response, cytokine storm or rush or whatever

Think I saw somewhere where rheumatoid arthritis drugs might be somewhat effective in treating this.

Could that be because RA drugs weaken the immune system (RA being an autoimmune disease) and give the patient a subtler immune response to the virus?

Again, way out of my wheelhouse. I'm a troubleshooter in professional life though and have always been interested in pharmacology/ biology.

Quote:

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Pretty sure I read in multiple places that the sars vaccine actually made people have a more severe immune response to SARS.

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Where did you read that? SARS vanished so quickly that they never got a vaccine through full trials.

Dr. Michael Osterholm has talked about it and you can pubmed search but basically SARS 1 vaccine trials in a percentage of animals created an Antibody dependent enhancement effect which basically produced some antibody but not enough to fight the disease and actually caused Infection aggravation.

goodAg80 said:

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WoMD said:

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dermdoc said:

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So basically the antibody can bind to a specific site and stop the virus from replicating.

And you could also attach different anti virals to the antibody to enhance binding and therefore efficacy against the virus.

So say you had a leech that if it attached itself to an animal, it could prevent that animal from reproducing. And then you could poison through the leech to not only stop it from reproducing but actually destroy it due to the affinity of the leech.

---

Not dumbed down enough.

---

A vaccine works by taking part of the virus or bacterium and injecting it into a person.Sometimes the whole thing, but only after it has been made non-functional. Why do this crazy thing? Because it won't make you sick since the virus or bacterium is made non-functional. OK, but why the **** do it even if it is non-functional? Because, your body detects non-functioning invasions just like functioning ones. [You are still not making this make sense]. When your body detects any invasion it starts to fight it in multiple ways and a very important one is to create "antibodies" that are the exact match (opposite structure) to part of the invading substance. These antibodies will stick to that part of the invading bodies. The other end of the antibody is like a GPS tracking device and your MONSTER MACRO.P.H.A.G.E.S track them down and eat the antibody and whatever it is sticking to. Infection is a meal and will be removed.

However, creating antibodies to fight new infections takes days. Sometimes that is too long.

Here comes the key: once your body makes antibodies they stick around for the next time some ******* infection comes along and they start their job immediately, That is how you get immunity. So a vaccine which did not make you sick, still created antibodies that will work on the fully functional infection.

Here is the even better part: sometimes the antibodies for one disease work for a different infection. This is what happens with the original small pox vaccine. People who got cow pox also got immunity to small pox!

This article is saying that the antibodies for the original SARS infection vaccine are working on CoVId19. If so we can just start using the SARS vaccine to gain immunity quickly.


Only we never funded the clinical trials for the SARS vaccine, so there isn't one.

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lazuras_dc said:

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Dr. Michael Osterholm has talked about it and you can pubmed search but basically SARS 1 vaccine trials in a percentage of animals created an Antibody dependent enhancement effect which basically produced some antibody but not enough to fight the disease and actually caused Infection aggravation.

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Just like this time, there was more than 1 attempt at a vaccine.

But this is exactly why we need animal trials and clinical trials of vaccines before we just rush out and give them to everyone.