Blood Type and COVID-19 Susceptibility?

2,891 Views | 19 Replies | Last: 5 yr ago by Marcus Aurelius
Keegan99
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6:08p, 4/9/20
AG
There was a Chinese paper (so take with a generously-sized grain of salt) that suggested individuals with type A blood were more vulnerable than the population at large, while those with type O were less vulnerable.

Has there been any additional research into this question?

What, if anything, is the theorized mechanism for why this might be the case?
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Cowbird
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7:57p, 4/9/20
AG
I remember something about o positive but don't understand why that would make a difference.
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SidetrackAg
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In reply to Cowbird • 8:01p, 4/9/20
AG
aggie2812-2 said:
I remember something about o positive but don't understand why that would make a difference.

This one?
https://www.webmd.com/lung/news/20200320/blood-type-may-affect-covid19-risk-study
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Barnyard96
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8:25p, 4/9/20
AG
Maroon blood is immune to COVID19.
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Marcus Aurelius
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8:29p, 4/9/20
AG
Been reading about this. Along with viral inoculation amounts, I suspect it is the main source of variability of attack rates among affected individuals. Basically - type O is protective. Type A is susceptible. Type O blood is seen in 59-85% of Mexico and lower equatorial countries which have much lower cases of COVID-19.

Very complicated Sars Cov-2 apparently can't bind well to type O RBC surface proteins and when it tries it creates a highly antigenic protein bond structure that is easily cleared by native immunity.

Type A pts, on the other hand, apparently have different cell membrane serine protease activity, which interacts with serine residues on the viruses S spike protein. This is also governed by ACE-2 receptors, which have differing phenotypes in ABO variability. The cell glycan/S spike binding structure is affected by differing serine protease activity making it more easily penetrated. This all translates to easier sars cov2 human cell entry into type A individuals.

My read of complex topic.
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Keegan99
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In reply to Marcus Aurelius • 9:11p, 4/9/20
AG
Thanks for the insight.

Interesting to see that there is a possible mechanism at play and it likely wasn't simply a random walk among the data in the Chinese study.

(I'm O, mom is O, but dad is A.... so... two outta three is good?)
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brownbrick
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9:14p, 4/9/20
AG
Glad I am type O.
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Double Twin Marine
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In reply to Marcus Aurelius • 9:18p, 4/9/20
AG


I'm type A, so in layman's terms...
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atag
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9:21p, 4/9/20
AG
O positive here!
proudest member of the fightin texas aggie class of 2005.
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Marcus Aurelius
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In reply to Double Twin Marine • 9:26p, 4/9/20
AG
You're more at risk. Rh status (+/-) not related.
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Tom Cardy
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In reply to Marcus Aurelius • 9:27p, 4/9/20
AG
Risk as in ability to become infected, or severity of outcome/symptoms?
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Double Twin Marine
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In reply to Marcus Aurelius • 9:27p, 4/9/20
AG
Marcus Aurelius said:
You're more at risk. Rh status (+/-) not related.


I got ya Doc. I was trying to be funny but apparently can't (or don't know how to) post a gif. Thank you for the reply though.
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Spaulding
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In reply to Marcus Aurelius • 9:58p, 4/9/20
Marcus Aurelius said:
Been reading about this. Along with viral inoculation amounts, I suspect it is the main source of variability of attack rates among affected individuals. Basically - type O is protective. Type A is susceptible. Type O blood is seen in 59-85% of Mexico and lower equatorial countries which have much lower cases of COVID-19.
I am guessing the range is because different Countries have different numbers ?
What is % of Americans are O ?
In The US is there a significant difference between Caucasians, Hispanic Caucasians , & African Americans
O vs A blood types?
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Keegan99
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In reply to Spaulding • 10:08p, 4/9/20
AG
https://www.redcrossblood.org/donate-blood/blood-types.html

Clickable tool here to show types by race.
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BenTheGoodAg
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10:08p, 4/9/20
AG
Well nuts...
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Complete Idiot
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10:23p, 4/9/20
https://en.wikipedia.org/wiki/Blood_type_distribution_by_country
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thirdcoast
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10:26p, 4/9/20
AG
What about cv19 survivor blood bank of antibody plasma donation?

I think that's the next best thing to a vaccine and is already in trial.
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Tabasco
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10:36p, 4/9/20
AG
What about AB (or does it only increase, if theory is correct, to A-only)?
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TAMU1990
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In reply to Marcus Aurelius • 10:57p, 4/9/20
AG
Marcus Aurelius said:
You're more at risk. Rh status (+/-) not related.
AB? And does this mean you are more likely to get it or more likely to have complications?
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swampstander
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11:05p, 4/9/20
AG
Male, Type A, 61 yrs old, 26.2 BMI, iffy blood pressure.... I'm doomed.
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Marcus Aurelius
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11:06p, 4/9/20
AG
Any type A antigen.. Regardless B association.
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