While this may seem counterintuitive if you know enough about the RAS system this seems likely that both esp ARBs may be useful in treating this disorder. There is animal and human evidence saying it might very well. I can provide references later if you want...
But it is odd that no one has even collected data for this already.. you need to see who is admitted, age , co-morbidities ( to try and at least find roughly equivalent groups as far as risk ) then just see if those patients are on ACE/ARB inhibitors) and who have confirmed COVID-19 (Sars-Cov2 ) have a higher survival rate than those who arent taking these medications. When you admit a patient you do ask what medication they are on .. then you could stratify later and use confidence and P levels( and DONT USE interquartile range. this is a mistake I see doctors make a lot including adding and dividing errors) JUST get roughly equivalent groups and at least see what the trend is. Then ask a mathematician NOT a statistician to help you.
I cant understand why a simple count of 40 records is beyond (20 with these meds 20 without) is seemingly beyond the capability of any doctor in the entire US). Yes it might take an hour or two but you know how to look at a patient record and get a rough idea as a guide about what to do in this case..
COVID-19 uses the ACE2 receptor and since covid-19 co-opts this receptor the body cant use it to regulate AT1/AT2 anymore? right? so now you use an ACE or ARB to take its place to facilitate ACE2 working properly. (ARB might be better than ACE because of one of its side effects which is a cough)
I realize doctors are busy with this but you do have a coffee break and it is important..... just sketch down the info from a few records everyday.. you are going to encounter many of these patients anyway ie New Orleans ... or NY .. Doctors and Nurses and others in hospital settings risk their life everyday, even 10 mins everyday to begin collecting this information could save even more lives... not to mention their own
But it is odd that no one has even collected data for this already.. you need to see who is admitted, age , co-morbidities ( to try and at least find roughly equivalent groups as far as risk ) then just see if those patients are on ACE/ARB inhibitors) and who have confirmed COVID-19 (Sars-Cov2 ) have a higher survival rate than those who arent taking these medications. When you admit a patient you do ask what medication they are on .. then you could stratify later and use confidence and P levels( and DONT USE interquartile range. this is a mistake I see doctors make a lot including adding and dividing errors) JUST get roughly equivalent groups and at least see what the trend is. Then ask a mathematician NOT a statistician to help you.
I cant understand why a simple count of 40 records is beyond (20 with these meds 20 without) is seemingly beyond the capability of any doctor in the entire US). Yes it might take an hour or two but you know how to look at a patient record and get a rough idea as a guide about what to do in this case..
COVID-19 uses the ACE2 receptor and since covid-19 co-opts this receptor the body cant use it to regulate AT1/AT2 anymore? right? so now you use an ACE or ARB to take its place to facilitate ACE2 working properly. (ARB might be better than ACE because of one of its side effects which is a cough)
I realize doctors are busy with this but you do have a coffee break and it is important..... just sketch down the info from a few records everyday.. you are going to encounter many of these patients anyway ie New Orleans ... or NY .. Doctors and Nurses and others in hospital settings risk their life everyday, even 10 mins everyday to begin collecting this information could save even more lives... not to mention their own