Literature on Vitamin D as a preventative is growing in breadth and depth. - A review

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culdeus
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8:30a, 4/28/20
AG
https://www.bmj.com/content/369/bmj.m1548/rr-6

Quote:
A remarkable recent preprint (Alipio),[26] entitled, 'Vitamin D supplementation could possibly improve clinical outcomes of patients infected with Coronavirus-2019 (COVID-19)', examines vitamin D status, and hospitalization outcomes in 212 COVID-19 patients, using 4 categories: (1) Mild without pneumonia, (2) Ordinary confirmed pneumonia with fever, (3) Severe hypoxia and respiratory distress, (4) Critical respiratory failure requiring intensive case monitoring. Alipio observes, "Vitamin D status is significantly associated with clinical outcomes (p<0.001). For each standard deviation increase in serum 25(OH)D, the odds of having a mild clinical outcome rather than a severe outcome were increased approximately 7.94 times; the odds of having a mild clinical outcome rather than a critical outcome were increased approximately 19.61 times," indicating that, in COVID-19 patients, increased serum 25(OH)D level could improve clinical outcomes, and/or mitigate the worst (severe to critical) outcomes. Conversely, decreased serum 25(OH)D levels could worsen clinical outcomes. Normal 25(OH)D levels were classified as >75 nmol/l (30 ng/ml). Deficient were those below 50 nmol/l (20 ng/ml). Deficiency definitions vary: <25 nmol/L, (10 ng/ml) UK; and 50 nmol/L (20 ng/ml) USA.[26]

Previous research and hypothesis have considered that Ethnicity may play more of a role than economic factors , that COPD is worse in those in past where Vit.D is low and can be a preventative as those that follow Dr. Coates know.

The daily dose for those is suggested here. (20-50ug)

For further reading

Why Vit-D is likely important in the fight against Cov19 in your body.
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Duncan Idaho
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8:36a, 4/28/20
I am sure I am literally pissing money down the drain but I am taking some D, C, zinc, and quercetin every day.
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Cancelled
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8:44a, 4/28/20
Pure bs on my part, but one would think that those who get outside and are active are more likely not to be obese and unhealthy. Just a thought...

I've never seen taken vitamin D, but I'll probably die of skin cancer from being outside.
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Tony Franklins Other Shoe
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In reply to Cancelled • 8:51a, 4/28/20
AG
queso1 said:
Pure bs on my part, but one would think that those who get outside and are active are more likely not to be obese and unhealthy. Just a thought...

I've never seen taken vitamin D, but I'll probably die of skin cancer from being outside.
Yeah, but at your open casket funeral, people will file by and say "man he looks great".
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murphyag
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In reply to Cancelled • 8:52a, 4/28/20
AG
queso1 said:
Pure bs on my part, but one would think that those who get outside and are active are more likely not to be obese and unhealthy. Just a thought...

I've never seen taken vitamin D, but I'll probably die of skin cancer from being outside.


I see lots of obese people outside all the time.

Working and/or spending time enjoying the outdoors doesn't keep a person from being/becoming obese.
Healthy eating and a regular daily cardio exercise routine does that.
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jagvocate
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9:05a, 4/28/20
AG
Appropriate sunshine without sunscreen is the best way to get Vitamin D

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culdeus
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In reply to murphyag • 9:46a, 4/28/20
AG
murphyag said:
queso1 said:
Pure bs on my part, but one would think that those who get outside and are active are more likely not to be obese and unhealthy. Just a thought...

I've never seen taken vitamin D, but I'll probably die of skin cancer from being outside.


I see lots of obese people outside all the time.

Working and/or spending time enjoying the outdoors doesn't keep a person from being/becoming obese.
Healthy eating and a regular daily cardio exercise routine does that.
Quote:
Obesity is a strong COVID-19 risk factor, as are co-morbidities, including diabetes, cardio-vascular disease; and sedentary lifestyle; all are dependent on mitochondrial functionality (Gnaiger).[14] Fat cells accrete vitamin D.[15] The obese consistently have proportionately lower vitamin D status (serum 25-hydroxyvitamin D [25(OH)D]).[16]
From the linked article.

Also the footnote related to obese people and Vit D levels here
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murphyag
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9:49a, 4/28/20
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Culdeus- I'm glad you are posting and bringing some light to the fact that obesity is very dangerous in regards to Covid-19. My Aggie neighbor down the road has been talking about this and wondering why more people and those in the media aren't.
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Reveille
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In reply to Duncan Idaho • 10:43a, 4/28/20
AG
Duncan Idaho said:
I am sure I am literally pissing money down the drain but I am taking some D, C, zinc, and quercetin every day.
Actually most doctors I know are taking those same supplements along with N-acetylcysteine (NAS). So you are not alone.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
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farmrag
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In reply to Cancelled • 10:52a, 4/28/20
queso1 said:
Pure bs on my part, but one would think that those who get outside and are active are more likely not to be obese and unhealthy. Just a thought...

I've never seen taken vitamin D, but I'll probably die of skin cancer from being outside.
Have you seen the farmers around here?
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normaleagle05
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11:05a, 4/28/20
AG
Rhonda Patrick did a video and email synopsis on this 4/16 & 4/18, respectively. I read the email but have not watched the video linked below. Content should be similar.

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rootube
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In reply to murphyag • 11:11a, 4/28/20
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murphyag said:
Culdeus- I'm glad you are posting and bringing some light to the fact that obesity is very dangerous in regards to Covid-19. My Aggie neighbor down the road has been talking about this and wondering why more people and those in the media aren't.
I get what you are saying but men are at a higher risk too and although it's an interesting fact, turning into a skinny chick is not an option for us big-boned gentlemen.
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DriftwoodAg
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In reply to Duncan Idaho • 11:13a, 4/28/20
AG
Duncan Idaho said:
I am sure I am literally pissing money down the drain but I am taking some D, C, zinc, and quercetin every day.
actually, Vitamin D is fat soluble...
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Not a Bot
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11:40a, 4/28/20
AG
Just started taking this myself.

Night shifts aren't exactly great for natural vitamin D. I hardly see sunlight right now and don't eat a lot of Vitamin D fortified foods. Maybe will help with some of the weird moods I've been in.
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eric76
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In reply to Duncan Idaho • 11:55a, 4/28/20
AG
Duncan Idaho said:
I am sure I am literally pissing money down the drain but I am taking some D, C, zinc, and quercetin every day.
I've been taking 5,000 international units if Vitamin D every day for years. Also something called a Super B Complex that contains B and C.
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KT_Ag08
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In reply to Reveille • 11:57a, 4/28/20
AG
Any concerns about longer term use of Quercetin? Most things I've seen online say to limit to 8-12 weeks. I have a bunch of the Quercetin Phytosome from Thorne at the house and wanted to make sure there wasn't anything specific to look for in terms of overuse.
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eric76
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In reply to jagvocate • 11:59a, 4/28/20
AG
jagvocate said:
Appropriate sunshine without sunscreen is the best way to get Vitamin D
Apprpriate sunshine means in the middle of the day. You don't get much Vitamin D from sunshine in other than the middle of the day. Also, you won't get much at all in the winter even in the middle of the day.
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Reveille
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In reply to KT_Ag08 • 12:14p, 4/28/20
AG
KT_Ag08 said:
Any concerns about longer term use of Quercetin? Most things I've seen online say to limit to 8-12 weeks. I have a bunch of the Quercetin Phytosome from Thorne at the house and wanted to make sure there wasn't anything specific to look for in terms of overuse.
Quercetin is a naturally occurring chemical found in our daily diet in fruits and vegetables. Not really at high doses in rats up to 1900 mg/kg it showed tumors in the kidneys at two years. But the average adult is over 70 kg so that would be like 133,000 mg per day. The smallest treated dose was 40 mg/kg which equates to 2800 mg per day. So staying under 2000 mg per day is likely safe. Let's hope we have a vaccine or herd immunity way before two years.

The second study they tested it in hamsters, rats and mice at very high doses again and they found it to be considered safe.

https://www.ncbi.nlm.nih.gov/pubmed/1459373

https://ucanr.edu/datastoreFiles/608-68.pdf
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
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KT_Ag08
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In reply to Reveille • 12:35p, 4/28/20
AG
Thanks, Doc. I figured as much. Like most of us, I've had too much free time and read a lot of really positive and then the BUT associated with Quercetin which gave me a little hesitation. Looks like a good thing to mix back in to the daily supplement regimen.
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culdeus
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7:31a, 4/29/20
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Another preprint. Almost seems too good to be true.

https://www.medrxiv.org/content/10.1101/2020.04.24.20075838v1
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beerad12man
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8:35a, 4/29/20
AG
So is it better to supplement it, or for those of us that go outdoors for a couple hours a day likely get enough? I've always been a "natural is better" kind of guy who rarely takes supplements if I feel I'm getting enough of something naturally.
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Keegan99
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In reply to culdeus • 8:45a, 4/29/20
AG


("VDI" is "vitamin D insufficiency")


Quote:

"We determined the frequency of VDI among COVID-19 patients to evaluate the likelihood of a VDI-COVID-19 relationship. Results: Twenty COVID-19 patients with serum 25OHD levels were identified; 65.0% required ICU admission.The VDI prevalence in ICU patients was 84.6%, vs. 57.1% in floor patients. Strikingly, 100% of ICU patients less than 75 years old had VDI. Coagulopathy was present in 62.5% of ICU COVID-19 patients, and 92.3% were lymphocytopenic. Conclusions: VDI is highly prevalent in severe COVID-19 patients. VDI and severe COVID-19 share numerous associations including hypertension, obesity, male sex, advanced age, concentration in northern climates, coagulopathy, and immune dysfunction. Thus, we suggest that prospective, randomized controlled studies of VDI in COVID-19 patients are warranted."

Looks like they found evidence of a correlation.

But get outside and get some sun. And drink some milk. Doesn't hurt.
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Cancelled
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In reply to murphyag • 8:46a, 4/29/20
Totally understood. However, I would imagine that unhealthy obese people are more likely to be on the couch than at the park, working outside, etc. but point definitely taken.
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tysker
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9:14a, 4/29/20
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Aren't African Americans (and dark skinned people generally) more susceptible to vitamin-d deficiency? More and more COVID seems like a sextuple whammy for overweight, black guys that live up north.
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Fannie Luddite
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10:55p, 4/29/20
AG
I listened to a podcast years ago about Vitamin D and the guest said it was next to impossible to get sufficient levels if you lived, say in Michigan, due to the decreased sunlight, especially in winter.

A blood test, done with a physical, should include Vitamin D levels. I was deficient a few years ago and have taken 5,000 IU daily since then.
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Reveille
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In reply to tysker • 10:58p, 4/29/20
AG
tysker said:
Aren't African Americans (and dark skinned people generally) more susceptible to vitamin-d deficiency? More and more COVID seems like a sextuple whammy for overweight, black guys that live up north.
Unfortunately yes due to pigmentation.


https://www.ncbi.nlm.nih.gov/pubmed/16549493
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lazuras_dc
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In reply to beerad12man • 8:12a, 4/30/20
AG
beerad12man said:
So is it better to supplement it, or for those of us that go outdoors for a couple hours a day likely get enough? I've always been a "natural is better" kind of guy who rarely takes supplements if I feel I'm getting enough of something naturally.
Quote:
Another study found that 30 minutes of midday summer sun exposure in Oslo, Norway was equivalent to consuming 10,000-20,000 IU of vitamin D (8Trusted Source).
https://www.healthline.com/nutrition/vitamin-d-from-sun#time-of-day

It would appear you should get enough from proper sun exposure according to this article and source.
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beerad12man
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In reply to lazuras_dc • 8:28a, 4/30/20
AG
Thanks. That's what I've always assumed
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george07
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1:28p, 4/30/20
AG
Quote:
Aren't African Americans (and dark skinned people generally) more susceptible to vitamin-d deficiency? More and more COVID seems like a sextuple whammy for overweight, black guys that live up north.

I'm not black but I am brown, and I was deficient a few years ago. My doctor told me you absorb less vitamin D from the sun the darker you are. So I've taken 2000 IU's a day since then and have good numbers now. Between that and my long daily walks over the past 6 weeks hopefully I'll be protected!
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culdeus
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8:54a, 5/5/20
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https://www.telegraph.co.uk/news/2020/05/03/time-take-seriously-link-vitamin-d-deficiency-serious-covid/

Telegraph with a solid article on the subject.
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beerad12man
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9:15a, 5/5/20
AG
But yeah, lets lock ourselves indoors and ban many outdoor activities. We've always had such ass-backwards thinking in this country. It's why we are obese/out of shape and most the country would rather spend their entire weekend at bars/restaurants than doing outdoor, physical activities. It's okay to go to home depot or walmart with 250 , but lets ban golf, state parks for a while, and camping still? Even 3 on 3 basketball isn't allowed? Yeah, f**ing stupid.
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Drip99
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10:09a, 5/5/20
AG
Is a multi vitamin enough or should i be buying up these supplements and taking individually?
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Charpie
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In reply to Drip99 • 10:14a, 5/5/20
AG
Depends.

Look at your multivitamin label and see if you are getting your recommended daily dose
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Rydyn
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11:05a, 5/5/20
AG
For the doctors...

Isn't an overdose of Vitamin D dangerous over a period of time? I thought there was a stasis relationship with calcium that your body can pull calcium out of the bones into the blood to maintain the relationship if you continue Vitamin D supplements at a high level.

What is daily dosage should we be targeting?
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beerad12man
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11:23a, 5/5/20
AG
Hasn't Reveille said not to take any unless you are deficient?

Most people naturally get enough.
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