Literature on Vitamin D as a preventative is growing in breadth and depth. - A review

517,993 Views | 51 Replies | Last: 5 yr ago by Sq 17
Tom Cardy
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He's recently switched to saying that you should probably take it unless you are already at a good level and could risk going too high. I'm taking a small amount daily now (1,000iu) just to supplement.
YouBet
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AG
Coincidentally, started taking a multi-vitamin back in January because my last physical showed that I was woefully under the recommended range for it. #officelife.

I'm getting 250% of vitamin D and 138% of zinc in that vitamin.
KT_Ag08
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Same story on the Vitamin D deficiency from being in the office all day. Was prescribed a supplement (silly probably) and now taking a multivitamin with about the same Zinc and Vitamin D levels as you. Not surprisingly, also spending a lot of time in the sun on the back patio and more tan than I've been in years.
culdeus
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I'm taking what Dr. Rev is suggesting dosage wise (50ug) until I get to a PCP for a blood draw to test levels.

It's not clear exactly how getting direct sun helps here. You get conflicting information about when/how much/sunscreen so would rather not take chance that I'm screwing that part up.
Reveille
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beerad12man said:

Hasn't Reveille said not to take any unless you are deficient?

Most people naturally get enough.
You don't have to take it if you are not deficient but a daily dose of 1,000 to 3,000mg is generally considered safe. Vitamin D toxicity is extremely rare and not really a concern. So if you don't know your level a daily dose is good to take particularity in the winter months when we are indoors more. In the summer a lot of people will have higher levels of vitamin D so hopefully this helps us ward of the virus some too.
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ToddyHill
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I wonder how one's milk consumption plays into this? The more one drinks the better off you are?
JD Shellnut
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Do we still need to quit vit D supplements if diagnosed with covid or has that line of thinking changed?
Habanero Guero
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Excuse my ignorance: Vitamin D and D3 are totally separate right? I take a D3 supplement, but is that not related to this?
Houston Astros- 2017 & 2022 World Champs
oragator
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Older and obese as well as darker skinned folks all are more likely to have vitamin D deficiency. So it might be corollary as much as causal, since those groups are more likely to have comorbidity.

Interestingly though, those in higher latitudes also are more likely to have deficiency, and if you think back a few months ago there was talk about certain latitudes getting hit harder.

Reveille
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Drifter. said:

Do we still need to quit vit D supplements if diagnosed with covid or has that line of thinking changed?
No new evidence shows it may actually slow inflammation and cytokine production during infection so no need to stop it.

Here is the link to the study
https://www.medrxiv.org/content/10.1101/2020.04.08.20058578v3
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
eric76
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Reveille said:

beerad12man said:

Hasn't Reveille said not to take any unless you are deficient?

Most people naturally get enough.
You don't have to take it if you are not deficient but a daily dose of 1,000 to 3,000mg is generally considered safe. Vitamin D toxicity is extremely rare and not really a concern. So if you don't know your level a daily dose is good to take particularity in the winter months when we are indoors more. In the summer a lot of people will have higher levels of vitamin D so hopefully this helps us ward of the virus some too.
In a seminar on Vitamin D by Dr. Holick that was shown on UCTV several years ago, he said that the only case of Vitamin D intoxication that he knew of happened when a manufacturer screwed up and was manufacturing Vitamin D supplements with about 100 times as much Vitamin D as what they should have contained.

Later, I did some web searches for the topic and found another instance that was very similar. That was a few years ago so there may be more now.
eric76
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culdeus said:

I'm taking what Dr. Rev is suggesting dosage wise (50ug) until I get to a PCP for a blood draw to test levels.

It's not clear exactly how getting direct sun helps here. You get conflicting information about when/how much/sunscreen so would rather not take chance that I'm screwing that part up.
I don't know how accurate it is, but I've read that in the summer sun, you can get about 15,000 IU of Vitamin D per day. They had a range, but all I remember is the 15,000 IU.
94chem
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I've been smashing these milks from the free school lunches like nobody's business. Turns out this is actually good for me?

Also, almost 70% of Asians are lactose intolerant. Not a lot of fortified milk in their diets.
94chem
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And why in the heck can't people trained in the sciences use actual units instead of this IU nonsense? %DV is almost as meaningless.

Matter comes in mass units. How much mass of vitamin D should be consumed per day?
Sq 17
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IUs are a mass unit and people struggle with decimal points followed by 0's also prefixes like mili or micro are difficult
Iirc 25 miligrams = 1000 iu's
Rydyn
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Sq 17 said:

IUs are a mass unit and people struggle with decimal points followed by 0's also prefixes like mili or micro are difficult
Iirc 25 miligrams = 1000 iu's
It's different depending on vitamin and potency of the chemical compound.

https://www.thecalculatorsite.com/articles/units/convert-ui-to-mcg.php
Quote:

Converting from mg or mcg to IU for Vitamins A, C, D and E
We've included mass equivalents of 1 IU for selected vitamins below. This information is from the Office of Dietary Supplements and the Ultimate Pharmacy Calculations Guide.
  • Vitamin A: 1 IU is the biological equivalent of 0.3 mcg retinol, or of 0.6 mcg beta-carotene
  • Vitamin C: 1 IU is 50 mcg L-ascorbic acid
  • Vitamin D: 1 IU is the biological equivalent of 0.025 mcg cholecalciferol or ergocalciferol
  • Vitamin E: 1 IU is the biological equivalent of about 0.67 mg d-alpha-tocopherol, or 0.9 mg of dl-alpha-tocopherol.

So my 2000 IUs (200% RDA) in my multivitamin is only 50 mcg.
culdeus
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https://www.medrxiv.org/content/10.1101/2020.05.01.20087965v1

Quote:

We explore historic evidence further supporting the causal model. We review biochemical mechanisms that may explain the various ways in which vitamin D acts. We detail the mechanisms by which the SARS-Cov-2 virus causes the disease and known pathways that involve Vitamin D and show how these both protect against viral infection, as well as ameliorating disease symptoms in COVID-19 and other respiratory diseases. We examine the factors that govern confidence in causal inference models and conclude that a high level of confidence in a causal beneficial role for Vitamin D is justified.
Sq 17
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Thanks for the added detail
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