Early study on tocilizumab

1,669 Views | 4 Replies | Last: 5 yr ago by Zobel
Zobel
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11:19a, 4/29/20
AG
https://www.apmnews.com/depeche/0/350489/premiere-etude-randomisee-favorable-au-tocilizumab-dans-le-covid-19%2C-en-france

Randomized controlled trial, sample side 129. No paper yet.


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A total of 129 patients were randomized: 65 for usual treatment + tocilizumab, and 64 for usual treatment.

The primary efficacy endpoint, which was the combination of ventilation need or death at 14 days, was significantly reduced with tocilizumab.

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Rachel 98
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In reply to Zobel • 11:20a, 4/29/20
AG
Great news! Hopefully production will be able to ramp up quickly since I know some of the MDs on here have mentioned having trouble getting toci.
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RandyAg98
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11:21a, 4/29/20
AG
Glad to see Marcus and some of the other MDs who have been optimistic about it now have some favorable data.
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Zobel
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11:26a, 4/29/20
AG
sarilumab on the other hand seems to disappoint.

https://www.statnews.com/2020/04/27/arthritis-drug-kevzara-disappoints-as-coronavirus-treatment/

Small sample size study in China with positive outcome wasn't replicated in a larger study.
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Marcus Aurelius
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In reply to Zobel • 11:39a, 4/29/20
AG
Interesting. Surprised sarilumab neg. Would think class effect. But TBH I am skeptical of anything from that country. Worldometer still has their total cases at 82000. Actually funny to think that anyone believes them.
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Zobel
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In reply to Marcus Aurelius • 11:46a, 4/29/20
AG
Sorry for being unclear - the small study in China was positive, but wasn't replicated with a 10x larger one.
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