https://www.statnews.com/2020/10/07/eli-lilly-monoclonal-antibody-cocktail-covid-19/
In the study, 112 patients received 2.8 grams of each of the antibodies, and 156 received placebo. The difference in viral load was statistically significant at day 11, unlike some doses of Lilly's single-antibody cocktail. There was also a statistically significant reduction in viral levels three days and seven days after infection.
The treatment also improved symptoms, according to a scored questionnaire, and resulted in fewer hospital and emergency room visits. Visits to the hospital or ER were made by 5.8% of patients in the placebo group, but just 0.9% of those who received the antibody combination. That difference, however, was just barely statistically significant.
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Lilly said it anticipates it could have as many as 1 million doses of its one-antibody treatment, LY-CoV555, available in the fourth quarter of 2020, with 100,000 available this month. But for the combination therapy, just 50,000 doses will be available in the fourth quarter of 2020.
Both antibody regimens have been well-tolerated, with no serious side effects, the company said. In the single-antibody studies, there have been reactions to the infusion of the treatment, which is given intravenously, including two "serious infusion reactions," from which patients recovered.
In the study, 112 patients received 2.8 grams of each of the antibodies, and 156 received placebo. The difference in viral load was statistically significant at day 11, unlike some doses of Lilly's single-antibody cocktail. There was also a statistically significant reduction in viral levels three days and seven days after infection.
The treatment also improved symptoms, according to a scored questionnaire, and resulted in fewer hospital and emergency room visits. Visits to the hospital or ER were made by 5.8% of patients in the placebo group, but just 0.9% of those who received the antibody combination. That difference, however, was just barely statistically significant.
...
Lilly said it anticipates it could have as many as 1 million doses of its one-antibody treatment, LY-CoV555, available in the fourth quarter of 2020, with 100,000 available this month. But for the combination therapy, just 50,000 doses will be available in the fourth quarter of 2020.
Both antibody regimens have been well-tolerated, with no serious side effects, the company said. In the single-antibody studies, there have been reactions to the infusion of the treatment, which is given intravenously, including two "serious infusion reactions," from which patients recovered.