Just curious if anyone on this forum has received the monoclonal antibody infusion? I have referred at least 50 patient's to our infusion clinic in Dallas and most all report significant improvement within 24 hrs. However, there have been some literature recently published that shows no improvement in overall patient care. Was curious if anyone has received the antibody infusion and what their experience was.

I had the infusion (Rogeneron cocktail). For reference, I felt symptoms on 1/6, tested positive 1/8, infusion 1/9. I did start the vitamin regimen on 1/6. I had classic symptoms fever, congestion, cough, some tightness In my breathing. As for the infusion, my heart rate jump immediately from 60 bpm to 90-95 bpm. It stayed that way for approx 9 hours. That was a concern as I felt horrible and jittery. After the 9 hours the heart rate came down to almost normal and I did feel better 24-36 hours later. Cough was still present but I felt my breathing eased. My O2 sat ran 92-93 prior to infusion but improved to 94-95 after the infusion.

Two family members got the "Bam" treatment - Dad back in Nov less than two weeks after it got EUA and sister about 3 weeks ago. He has no underlying health conditions so age (68) was his only known risk factor at the time. He got it on day 10 or 11 which I think is outside the recommended early treatment. Sister has several high risk factors and got her infusion the day she was confirmed positive.

Both of them had really rough nights after the infusion. Next day Dad turned the corner quickly but obviously don't know what to attribute that to - AB treatment or virus running its course 11 days in...maybe some of both. Sister has managed to stay out of the hospital which is huge given her medical history.

My biggest question on these infusions is how they potentially interfere with vaccines and when family should consider getting vaccines if that is the recommendation.

I tested pos on 1/10 in Crested Butte, drove home SA on 1/11 and had antibodies transfusion on 1/12. Felt much better on 1/13 and was 90% plus within 3 days thereafter. I am a fat ass and got scared when a buddy came down with viral pneumonia on Day 10 of his Covid trip then spent 6 days in hospital. He was fine. My doc was the hero here - not sure who he called or what boxes he checked to get me in for transfusion but very grateful.

BTW, I had zero side effects from transfusion

Where did you get the infusion? Hospital setting? Out patient clinic?

Who is your doc in SA? Worried mine won't do anything so another option would be awesome

I had the infusion in December at one of the Methodist Hospitals in Houston.

No bad effects. Felt better within 24 hours. Got the infusion two days after testing positive but at least seven days after symptoms.

Received my infusion in Victoria at Citizens Hospital.

I did have a slight reaction as noted previously but feel very fortunate to have received the infusion as I feel it helped getting well sooner.

Glad to see people are getting this treatment

Metropolitan Methodist ER Site at Quarry Market. They are doing 4 transfusions/days at this location.

McKinney Ag said:

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Two family members got the "Bam" treatment - Dad back in Nov less than two weeks after it got EUA and sister about 3 weeks ago. He has no underlying health conditions so age (68) was his only known risk factor at the time. He got it on day 10 or 11 which I think is outside the recommended early treatment. Sister has several high risk factors and got her infusion the day she was confirmed positive.

Both of them had really rough nights after the infusion. Next day Dad turned the corner quickly but obviously don't know what to attribute that to - AB treatment or virus running its course 11 days in...maybe some of both. Sister has managed to stay out of the hospital which is huge given her medical history.

My biggest question on these infusions is how they potentially interfere with vaccines and when family should consider getting vaccines if that is the recommendation.

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Wouldn't get a vaccine at the same time as antibody treatment. I have seen recommendations of waiting 3 months after recovery from COVID before getting the vaccine. AB treatment should have cleared the system long before then, so 3 months would still be reasonable post COVID before getting vaccine. Keep in mind, a person is likely to have immunity for at least 6 months after getting COVID, so getting the vaccine in a 3-6 month time frame is really just a booster for the immunity from the actual disease.

Your PCP send you over or called em up? If PCP, would love their info

Personally seen a couple patients die despite receiving monoclonal antibody treatment, seen several that developed severe disease, also one of my good friends parent died despite receiving it. When there is a low probability of death, most treatments are going to look effective to those prescribing it, given ~98% of the population receiving it will not die from COVID. At best, it doesn't appear to be remarkably effective, based on my experience seeing these patients in the ER and ICU.

The currently available literature does not demonstrate any clinically meaningful efficacy, at least the way that it is currently being utilized, and it makes sense why that it is. Patient's have been infected generally between 4-8 days prior to developing symptoms, it then usually takes an individual an additional 2 days to get tested, and an additional 1-2 days to get set up with antibody infusion therapy. The majority of individuals will likely already have circulating antibodies by this point making the utility of antibody infusion therapy moot. The bambam industry funded trial was stopped early due to futility and then the data was tortured enough to find some semblance of maybe benefit, however, clinically meaningful benefit like death or development of severe disease was not altered by the therapy.

I'd imagine this would be potentially beneficial if given prior to symptom onset in individuals with extremely high risk exposures (living with someone who is positive) who have a high probability of severe disease; however, given how expensive this medication is and its suspected affect on vaccine efficacy, the cost:benefit ratio is just way too high.

A doctor whose opinions on medical literature I trust wrote about the currently available evidence for this therapy in the article I linked below.

https://emcrit.org/pulmcrit/followup-bamlanivimab/

AgsMyDude said:

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Your PCP send you over or called em up? If PCP, would love their info

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The San Antonio Methodist system has established a few transfusion sites at a couple of their free-standing ERs. Approval for these transfusions either needs to be done from a Methodist ER if diagnosed there and discharged, or set up by your PCP; however, you need to meet certain criteria prior to approval.

Dr. Not Yet Dr. Ag said:

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AgsMyDude said:

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Your PCP send you over or called em up? If PCP, would love their info

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The San Antonio Methodist system has established a few transfusion sites at a couple of their free-standing ERs. Approval for these transfusions either needs to be done from a Methodist ER if diagnosed there and discharged, or set up by your PCP; however, you need to meet certain criteria prior to approval.

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Thank you!