Quad Dog said:
It would take a lot more infrastructure than you think: large studios to shoot big scenes; multiple smaller studios; warehouses to store props, costumes lights, etc.; outdoor areas for outdoor shots.
Then you need people living nearby for writing, acting, lighting, electrical, makeup, hair, costumes, and executives.
Also good weather so that outside shots can be made almost year round without losing money to reschedule. Hollywood also has close access to many types of backgrounds: mountains, oceans, plains, desert, city, farm.
It's possible but it would take a huge investment to make it happen. And not many other places would have those last two qualities.
Here's a aerial shot of the Warner Bros studio. Why rebuild all of this?

My old house is just out of frame.
As TCTTS pointed out, there are a lot more studios than that.
Even this shot of Warner Bros, doesn't include the Warner Brothers Ranch a mile north on Hollywood Way.
Can't say enough about the people who are required. People who have some specialized skill or no skill at all who are willing to pay through the nose to live in the TMZ or commute in, for the opportunity to get paid a high hourly wage (or residuals for the actors, etc.) for those few days when they actually work.
There are a high number of people living in LA who live in a crappy $1500/month 1bdr apartment in the bad part of town who are hoping to make it while being supported by money from home or whatever.
Because of all the freedoms/lawlessness in LA, I don't think these people are going to go anywhere else.
Of course in a post-Covid world, things are different. From my perspective, the whole place is pretty much dead but, I'm sure it will rally back even as prices go higher for everything.
Most of the creative types who are needed and willing to take these jobs aren't going to go live in Neom, Saudi Arabia because of all the things the Saudis won't let you do that you can freely do in LA.
Bottom Line - it's not just the infrastructure, it's the people too.