To us oldies, Kenedy and Karnes City are old friends. Before the expressways through San Antonio, everyone from the valley avoided driving through San Antonio like the plague. You had to drive through downtown and it was a maze of streets. Instead of this, most folks used to drive around San Antonio and go through Kenedy and Karnes City. (Alice to Kenedy/Karnes City to Seguin to San Marcos).
I need to drive that road again, it has been many years. (My girl friend/wife went to school at SW Texas - or whatever you call it now).
My little sister lived in Karnes City for a while. It is pretty rural and I don't think she liked it much, but that basically depends on you. When you are getting started you don't have a lot of options. After you get some experience, you will be able to look in some more attractive locales.