For a macrolide allergy ? No.Shumba said:
This sounds promising. Quick question. What if you can't take zithromax? Any alternative meds that would work with this treatment?
First 2 cases of confirmed COVID-19 in my hospital......
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Last: 5 yr ago by Ranger222
Marcus Aurelius said:IMO the limited testing has been a disaster. They should have been developing high thru put testing much sooner. Also think the social distancing was implemented a little too late.1/2 Man 1/2 Amazing said:
OP....I'm curious, what are your thoughts on how the nation has fought this (our current quarantine rules) and how do you think we should continue and for how long??
you can perhaps give some credit to The NBA for getting a 'social distancing' ball really rolling. Had Gorbert not tested positive and the NBA not immediately suspended that night, it might have been a few more days before enough pressure built. But once the NBA folded, seemed like a match that lit the fire, at least in sports world. And once all the sports started cancelling, that finally got a lot of the public's attention that the world was not business as usual. That and the travel ban announcement with Europe. What a weird night that was when all that was happening.
Yeah, the interesting part is you still had a lot of people who didn't see the big picture. I think it was one of the college basketball commentators at halftime of one of the conference games that night of the Jazz/OKC game that said "I think we've seen our last college basketball game this year".
People were still thinking we'd be playing sans-fans.
People were still thinking we'd be playing sans-fans.
Even though it is an antibiotic, azithromycin has been known to have some anti-inflammatory properties.
I believe it may be working as an IL-6 inhibitor (at least in part). I wonder if treatment will be eventually changed to hydroxychloroquine + IL-6 inhibitor
I believe it may be working as an IL-6 inhibitor (at least in part). I wonder if treatment will be eventually changed to hydroxychloroquine + IL-6 inhibitor
How many of your hospitals have cancelled elective cases? I sit in the OR as I text this because they added close to 20 elective cases today and more than 10 tomorrow. This is very frustrating, since the admins are not the ones managing airways.
Everybody please stay safe.
I'm not naming hospital, was just wondering.
Everybody please stay safe.
I'm not naming hospital, was just wondering.
Seems to be more virulent in men than women for whatever reasons.Marcus Aurelius said:
Similar symptoms. Milder presentation. Mild hypoxia initially hence admission. She is much better now.
All elective, non-emergency surgeries have been cancelled in Colorado, That includes dental and veterinary as well.
Surprised to hear that. Friends knee replacement postponed for several months until May for now. I would "elect" to avoid the hospital for the time being.jsm0417 said:
How many of your hospitals have cancelled elective cases? I sit in the OR as I text this because they added close to 20 elective cases today and more than 10 tomorrow. This is very frustrating, since the admins are not the ones managing airways.
Everybody please stay safe.
I'm not naming hospital, was just wondering.
Three of four hospitals in my area have cancelled all elective procedures. The fourth one was actively soliciting elective cases, meanwhile their ER docs went out and bought masks from Sherwin Williams because they know they will have a shortage of PPE. Ridiculous.
If those meds end up proving to work, I hope in the coming weeks we don't have to be sick for a week and at the point of needing to be hospitalized in order to get started on them.
That is the ultimate goal once production ramps up. Have to preserve current stock for severe cases. Once testing and production of meds ramps up we treat proactively. Think Tamiflu for COVID-19.aggie-beta said:
If those meds end up proving to work, I hope in the coming weeks we don't have to be sick for a week and at the point of needing to be hospitalized in order to get started on them.
Good info on this thread:
https://texags.com/forums/84/topics/3101098/1#discussion
It becoming increasingly clear that the fact these meds are working is not anecdotal or a randomized chance occurrence.
This is a fascinating explanation of how COVID-19 works.boulderaggie said:
First time I've noticed Zinc mentioned. We religiously take Zicam before and after travel and at first indication of not feeling well. Has there been any more talk about the use of zinc wrt COVID-19?
At 14:45 in the video, the doctor mentions a 2010 study that demonstrates Zinc's ability to inhibit coronavirus, but in the study the zinc was introduced in vetro, not orally via supplements or lozenges.
(Credit another TexAgger for this video, as they posted it last week: )
This was addressed on page 25 of Reveille's thread...boulderaggie said:
First time I've noticed Zinc mentioned. We religiously take Zicam before and after travel and at first indication of not feeling well. Has there been any more talk about the use of zinc wrt COVID-19?
BioChem's comments also further down on that page...Quote:This is one is rather complicated I am looking for some good information for you. I think all of the above are a good idea.Quote:
fullback44 said:
Sorry not sure how that imoj got there
Doc, I have a question regarding taking vitamins. I started taking them in fairly high doses about 3 weeks ago. Vit D 10,000 -15000 + plus units a day, 1000 % daily Vit C also, 1 selenium and 1 zinc a day. Anyway, I'm having issues w the pollen and my lower back (kidneys I believe) have been really starting to bother me. I increased my water intake and it has helped, but I can still feel some pain. I get some fever w my allergies also (who knows maybe Covid)
Can you give a guideline as to what's a safe but healthy limit on taking some of these vitamins so that I don't cause other bodily harm? Should I be taking a lower quantity?
But essentially Zinc in the lab if it is intracellular it can potentially slow down or inhibit the the replication the virus by blocking the enzyme replicase which sounds awesome. Everyone should take take zinc then. NO SO FAST!! Zinc is charged ion +1 which keeps it outside the cell. In order to get inside the cell you have to have an ionophore which essentially opens a gate allowing the Zinc to get into the cell. There are studies showing that chloroquine opens these gates allowing Zinc to now get inside the cell. So I think taking Zinc is likely a good idea. I take it for my prostate I just don't know a good ionophore to allow the Zinc to get into the cell. If you get ill and are given hydroxycholoroquine it would be good to have zinc around to be get into the cells when the gates are opened.
Keep in mind these are all in laboratory studies and trials are ongoing. Zinc has been shown to potentially help in some cancers. I take it for my prostate so I don't see any harm in it.
Maybe a microbiologist or virologist could give us more information on this.
Quote:
Some zinc will get inside the cell. increasing zinc outside the cell will lead to an increase of zinc inside the cell, so taking zinc is fine and will increase intracellular zinc conc, but maybe not enough to completely shut down the virus. An ionophore makes it easier and increase the intracellular concentration even more.
Btw, it is Zn2+ that has been shown to be effective, which is what OTC Zn supplements contain.
And here's a video explaining how/why Zinc + chloroquine may be effective for the treatment of COVID-19:
My patient worse today. High fever. LFTs higher (portends worse respiratory failure). Although WBCs up. This disease seems to undulate. Not intubated - yet.
What day is the patient currently on post symptom?
approximately day 8
Undulations seem to occur from some of the first hand accounts I have been reading. How many days has the patient been on the meds you mentioned yesterday?
4th day.
just greatMarcus Aurelius said:
My patient worse today. High fever. LFTs higher (portends worse respiratory failure). Although WBCs up. This disease seems to undulate. Not intubated - yet.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
Stay the course Marcus. We are so early into this that we all are effected positively or negatively day to day with every bit of news.
Persistence will pay off and I am sure your patient will beat this as will his wife.
Persistence will pay off and I am sure your patient will beat this as will his wife.
I wish there were some statistics on how many severe cases were also smokers.
Here in Aggieland CHI sent an email out mid last week that there were stopping elective stuff.jsm0417 said:
How many of your hospitals have cancelled elective cases? I sit in the OR as I text this because they added close to 20 elective cases today and more than 10 tomorrow. This is very frustrating, since the admins are not the ones managing airways.
Everybody please stay safe.
I'm not naming hospital, was just wondering.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
Thanks for your updates Marcus really appreciate them. Luckily I shouldn't have to deal with this much in your setting but I still like the info as I am high risk of exposure over time.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
Ranger222 said:
Even though it is an antibiotic, azithromycin has been known to have some anti-inflammatory properties.
I believe it may be working as an IL-6 inhibitor (at least in part). I wonder if treatment will be eventually changed to hydroxychloroquine + IL-6 inhibitor
I will second this. I tend to get pneumonia and use the Z-Pack both as a antibiotic and an anti-iflamation. I ALWAYS respond well with ZPack.
My critical care pulmonologist told me years ago it was a unintended outcome....but hey it is nice to have a good side effect from a drug.
Pelayo
Are you still looking for mask? I've for 30 or so of the N95 from Homedepot I could send you.. we use them for chem testing ... also have 2 boxes of plastic gloves.
If so, send me an address and I will try to over night them to you, will depend if shipping places open.
Are you still looking for mask? I've for 30 or so of the N95 from Homedepot I could send you.. we use them for chem testing ... also have 2 boxes of plastic gloves.
If so, send me an address and I will try to over night them to you, will depend if shipping places open.
I will PM you, thank you.fullback44 said:
Pelayo
Are you still looking for mask? I've for 30 or so of the N95 from Homedepot I could send you.. we use them for chem testing ... also have 2 boxes of plastic gloves.
If so, send me an address and I will try to over night them to you, will depend if shipping places open.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
Marcus Aurelius said:
My patient worse today. High fever. LFTs higher (portends worse respiratory failure). Although WBCs up. This disease seems to undulate. Not intubated - yet.
Does the elevated wbc cause any concern about the cytokine release that's been noticed with this?
Weren't there reports out of China of patients seeming to turn a corner, and then going into respiratory failure and dying a day or two later?Marcus Aurelius said:
My patient worse today. High fever. LFTs higher (portends worse respiratory failure). Although WBCs up. This disease seems to undulate. Not intubated - yet.
Really hope that's not happening with your patient.
jsm0417 said:
How many of your hospitals have cancelled elective cases? I sit in the OR as I text this because they added close to 20 elective cases today and more than 10 tomorrow. This is very frustrating, since the admins are not the ones managing airways.
Everybody please stay safe.
I'm not naming hospital, was just wondering.
Every hospital and ASC where I do cases has cancelled elective cases. If you want to put on a case, anaesthesia has to review. I'm an ENT. Our Academy has been warning us that, due to the high viral load in the nasopharynx, our cases should be postponed if possible. They've also been telling us that we are way at the top as far as our risks of contracting Coronavirus, with MULTIPLE otherwise healthy ENT doctors having died of it in China, Iran, and Italy. Ugh.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
He is tough as sh**. Degree of infiltrates on CXR / CT is impressive. IMO his WBC increase (from 3 to 6 K) is an improvement? But who knows with this. Scary!!!!!!!!!!! I am having to take my temp 4 x a day and graph based on our hospital protocol (exposures to COVID even with PPE). Only going to get worse.
Today my sick patient is about the same if not a little worse. WBC up to 9K. LFTs down slightly. CXR worse and slightly more hypoxic. Afraid he is going to tire and get intubated soon.
Wife DCd home off O2.
Wife DCd home off O2.
McInnis 03
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Praying for that man
Marcus,
Any pre-existing conditions on the patient?
Any pre-existing conditions on the patient?
v/r
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