Marcus Aurelius said:

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The young man is Covid negative.

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Are they going to scan him and find a boot stuck in his ass? Cause they should. Not necessarily scan for it, but find one stuck there anyway.

Pretty sure the shovel is for an outhouse hole.

Marcus Aurelius said:

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Many false negatives. I'd say up to 30%. In fact - have seen 3 new COVIDs today. 2/3 with several neg swabs but obvious disease clinically. So operator dependent.

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Based on those numbers and how intimate you are with how serious this is, are you going to continue to assume he was positive until the 14days are up?

Or is it "whew, glad that was nothing"?

She is relatively "quarantining" from us for a while. He is much improved. Afebrile. So probably a cold. He got swabbed at UAB. Locally they are probably the best technique IMO.

Thanks. I know how I would react...I was curious how someone with your training and experience would react.

From my biology degree, I know just enough to scare the **** out of me but not enough to be hopeful.

Basically the worst of the Dunning-Kruger effect.

Weird flex

Wtf....you are so flippen weird .

Suspect you're positive. False neg rates high as 30%. Stay quarantined. If you develop shortness of breath or chest pain that is significant go to ER. A pulse oximeter would be helpful to monitor your O2 sats if you could obtain one.

ToddyHill said:

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Marcus,

Would appreciate your thoughts regarding my situation...

I work in an Essential business. Was exposed to two co-workers who tested positive about a week ago.
I've been tested twice, once by the health department, the other a quick test. Both were negative.
48 hours ago, I became symptomatic.
Temperature is now 100.8, dry cough, chills and a lot of shakes at night, very fatigued, chest is sore.
Breathing OK and I have not lost my sense of smell.
I'm 63 years old.
The Health Department has been in contact with me and suggested a third test today (which I did).
My sister is a nurse, She strongly suspects I'm positive.
I'm hydrating, and taking Tylenol.

My temperature, which was around 99.8, has been slowly rising today. Thoughts please?

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I would also immediately start taking zinc 50mg per day, Quercetin 1g twice per day, CoQ10 300mg per day and Vitamin D 5000IU per day. You might consider N-acetylcysteine also as it is another antioxidant to help decrease oxidative stress. Read my update later tonight on CoQ10

Hang in there. Wish I could do something else for you.

Take care of yourself.

ToddyHill said:

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I'm taking Vitamin C and Vitamin D presently. My wife is going to pick up the Zinc tomorrow. I'll tell her about your other suggestions.

The irony is that I felt great this afternoon, and thought I had beat this, but around 5 p.m. it did a 180 degree turn.

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Get Quercetin as soon as possible as similar to hydroxycholorqine it is a potent zinc ionophore and allows zinc in the cell to inhibit replicase which is the enzyme the virus uses to replicate. I would take a couple when you get them as soon as possible. I have them in my desk and I take an extra one every time I am exposed to a potential Covid-19 patient.

Also CoQ 10 is a potent antioxidant and has helps prevent most of the mechanisms of damage to Covid-19. I will give you more details in my update a little later tonight.

Wow, you guys are awesome. Thank you!!!!

Toddy, if your wife can't find any Quercetin, I'll be on the lookout and get some for you and drop it off if you need.

Coenzyme Q10 could it be helpful now that we know Covid-19 is potentially an endothelial disease potentially leading to oxidative stress?

CoQ10 decreases with age and is a naturally occurring antioxidant that is also an important component of the mitochondrial electron transport chain to produce ATP (The currency of cells). CoQ10 is a strong hydrogen donor making it a potent antioxidant. Remember our three road analogy. This is what fixes the holes (Holes are the reactive oxygen species ROS) in the road.

So how do we increase CoQ10? Well the best way is with diet and exercise. Work on losing 10% of your body weight. But this doesn't work for everyone. Some of us need supplements. CoQ10 supplements are widely used in combination with statin drugs to decrease the potential muscle aches that statins sometimes cause. But they have many other benefits that we need to look at.

So Ubiquinol or the reduced form of COQ10 stops the initial process of lipid peroxyl radicals' formation. (Keeps potholes from even forming).

A study in patients with Coronary Artery Disease (CAD) to determine the effect of COQ10 100 mg of the endothelium-dependent vasodilatation activity of extracellular superoxide dismutase (ecSOD). The results demonstrated that in the COQ10 treated group in comparison with the placebo group: extracellular superoxide dismutase (breaks down reactive oxygen species), endothelium-dependent relaxation was statistically higher. (This is really good as this fixes the holes in the road and increases blood flow to lungs with vasodilation.)
In another study with CAD, the amount of COQ10 300 mg. After the beginning of COQ10 supplementation, the extent of anti-inflammatory markers (TNF-, p=0.039) was significantly lower. In comparison with the placebo group, the levels of vitamin E (p=0.043) and the antioxidant activities of enzymes (p<0.05) were remarkably higher after 12 weeks. Therefore, COQ10 level in plasma had positive correlation with the antioxidant activity of enzymes (p<0.05) and vitamin E (p=0.08) and negative one with interleukin-6 (IL-6) (p=0.027) and TNF- (p=0.034). These two things IL-6 and TNF- are largely responsible for the cytokine storm. (Excellent news as this not only is fixing the road but it is also helping prevent the future big crash!!)

In another study with patients with a heart attack and high cholesterol. It showed benefits and the protective effect of COQ10 can be explained by its influence on coagulation (making clots). Administration of 100 mg of COQ10 twice daily for 20 days led to a three-fold increase of total serum COQ10 level with a decline in plasma fibronectin (-20.2%), thromboxane B2 (-20.6%), prostacyclin (-23.2%), and endothelin-1 (-17.9%) level (these all cause clots so good to go down) as well as inhibition of vitronectin-receptor expression and reduction of platelet size. (This is also important as we now believe that Covid-19 causes significant clots.)

So this supplement while it may not help protect you from Covid-19 like some of the others it has very significant effects that could help prevent you from getting severe disease. It is counteracting most of the mechanisms we have recently learned that Covid-19 uses to harm us. Covid is causing vasoconstriction and CoQ10 is potentially causing vasodilation. Covid is causing an increase in IL-6 and TNF- to cause the cytokine storm while CoQ10 is decreasing these inflammatory markers. Covid is causing you to increase your ability to clot while CoQ10 is decreasing it. And most of all Covid we now believe is causing a dramatic increase in oxidative stress (the potholes) while CoQ10 is a potent antioxidant. (fixing the holes)

Moreover, CoQ10 has significant benefits in diabetes, heart disease, hypertensive, and metabolic syndrome patients. See a correlation there, in studies we now know diabetics, heart disease, HTN and obesity are the highest risk factors for severe disease in Covid-19. While most people take 100-300mg CoQ10 is a safe supplement and has an observed safe level up to 1200mg per day. Only real side effect is an upset stomach at high doses.

In addition it has shown to decrease Migraine headache frequency and intensity in studies. It also has been shown to be potentially beneficial in other neurological diseases. Ironically, reducing statin myalgias is not consistently shown in clinical trials.

In summary it helps balance oxidative stress and inflammation in your body. It helps with vasodilation decreasing pulmonary artery pressure and it also has potential benefits as an anticoagulant. All the exact opposite of what SAR-COV2 does in your body.

So now based on all of this information I think this is definitely something we should be taking. Only question is what dosage should we use? Most studies are between 100-300mg per day.

Link to article
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131403/

Link to previous post on the 3 roads in case you missed it.
https://www.facebook.com/permalink.php?story_fbid=2683189138630693&id=1998386763777604&__tn__=K-R