Early Human CoVid Vaccine Trials
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Last: 5 yr ago by BamaAggies
This is good news
Question: if this vaccine works and is going to be approved for emergency use could we give it to teachers?
Treat teachers like health care providers. I'm assuming the hang up with schools opening is the teachers more than the kids since they are more at risk.
Treat teachers like health care providers. I'm assuming the hang up with schools opening is the teachers more than the kids since they are more at risk.
There were some side effects, however.
Give them to every Div 1 football player. If they don't get sick, then we have something great!
On the Seattle woman...I understand her taking normal precautions but wouldn't you want at least one subject of the study to engage in relatively "high-risk" activities to prove the vaccines effectiveness?
Great news
Pfizer: 100 million doses by EOY would be fantastic
Maybe they can start injections in October-November
Pfizer: 100 million doses by EOY would be fantastic
Maybe they can start injections in October-November
will teachers willingly sign up to receive an experimental vaccine in the first rollout?
what I'm seeing in my various feeds leaves me skeptical
what I'm seeing in my various feeds leaves me skeptical
Experimental vaccine.
Rushed into existence.
First people to get the initial run is all of the first responders.
Actually sounds like a terrible idea that doesn't account for the possibility of unforeseen side effects. Let's make the people we need the most healthy, testing subjects.
Like the 1976 flu outbreak.
https://en.m.wikipedia.org/wiki/1976_swine_flu_outbreak
Rushed into existence.
First people to get the initial run is all of the first responders.
Actually sounds like a terrible idea that doesn't account for the possibility of unforeseen side effects. Let's make the people we need the most healthy, testing subjects.
Like the 1976 flu outbreak.
https://en.m.wikipedia.org/wiki/1976_swine_flu_outbreak
Yes I would. The only thing I would want is financial security for my family if the vaccine did not work and I died or if the vaccine cause death or permanent debilitating injury.cone said:
will teachers willingly sign up to receive an experimental vaccine in the first rollout?
what I'm seeing in my various feeds leaves me skeptical
The other comment is ridiculous. Most teachers want to go back, they just do not want to go back with no precautions and 30 kids a class. WE WANT A PLAN THAT TAKESS OUR SAFTY INTO ACCOUNT and does not rely on the BS claim kids don't pass it along.
does an experimental vaccine take your safety into account?
It's not experimental if it's passed out of Phase 3 trials, is it? It would be a new drug, but no longer experimental.
Sign me up
Sign me up
Yeah but I also feel fantastic and I never got the vaccine.goodAg80 said:
https://www.foxnews.com/health/maryland-man-may-be-first-person-successfully-vaccinated-against-covid-19
https://komonews.com/news/coronavirus/first-seattle-volunteer-in-human-covid-19-vaccine-trials-says-she-feels-fantastic
Let's hope these pan out!!!
Bucketrunner said:
It's not experimental if it's passed out of Phase 3 trials, is it? It would be a new drug, but no longer experimental.
Sign me up
To be factual it will has passed Covid "Phase 3" not a traditional Phase 3. Everything about the vaccine has been accelerated to lightning speed, so I'm not sure it is fair to say both are exactly equal.
This is reminding me of the opening of I Am Legend. I hope Will Smith is working on this too.
Actually 2 of the leading vaccine candidates have been worked on for multiple years. They're SARS virus vaccines. Their approval, IRB, phase 1 &2 have not been that much faster than normal. Certainly the phase 2 to 3 period has had less regulatory hurdles than normal but they've already passed a basically normal safety and efficacy study period successfully.
Aggie95 said:
On the Seattle woman...I understand her taking normal precautions but wouldn't you want at least one subject of the study to engage in relatively "high-risk" activities to prove the vaccines effectiveness?
Apparently that's not how this works.
If a huge portion of the population isn't willing to wear a mask, what makes you think they'll get a vaccine?
If the vaccine conveys lifetime or at least long term immunity I think you will see most participate.
If it is a flu type immunity I don't see how you get over the 45% that take the flu vaccine.
I say that as someone who is a big proponent of vaccination, just a strong skeptic of the timelines.
If it is a flu type immunity I don't see how you get over the 45% that take the flu vaccine.
I say that as someone who is a big proponent of vaccination, just a strong skeptic of the timelines.
There isn't a huge portion, it's a small but vocal portion. And yes I do assume they will say "the vaccine is about control".Silky Johnston said:
If a huge portion of the population isn't willing to wear a mask, what makes you think they'll get a vaccine?
lol the paranoid style in America is absolutely not limited to the RW nut jobs who talk about it in terms of control
the real resistance is going to come from highly vulnerable groups that remember the Tuskegee experiments
and they've got a point
the real resistance is going to come from highly vulnerable groups that remember the Tuskegee experiments
and they've got a point
I've had a couple beers and don't feel like googling, please explain?
The Tuskegee experiment involved medical professionals basically lying to a large group of African American men. They claimed to be helping treat their "Bad Blood" which was slang for syphillis back then. They instead didn't do anything and just analyzed how the disease attacked the patients.
https://www.cdc.gov/tuskegee/timeline.htm
https://www.cdc.gov/tuskegee/timeline.htm
What's the old saying...
Just because you are paranoid doesn't mean they aren't out to get you. :-)
This reminds me of the story about how the guy credited with developing statin therapies,
Akira Endo, wouldn't take them himself.
https://blogs.scientificamerican.com/news-blog/cholesterol-drug-scientist-receives-2008-09-12/
A 2006 profile of Endo noted that he briefly took Mevacor, a Merck statin produced with a fungal byproduct close to the one he discovered. But Endo stopped taking it, and when a doctor found he still had elevated LDL, he decreased his levels by exercising, he told the Wall Street Journal.
When asked why, he gave the Journal a cryptic answer in the form of a Japanese proverb: "The indigo dyer wears white trousers."
Perhaps it would inspire confidence if all the Moderna, Merck, and AstraZeneca employees (particularly executives) were enrolled in the trials.
Just because you are paranoid doesn't mean they aren't out to get you. :-)
This reminds me of the story about how the guy credited with developing statin therapies,
Akira Endo, wouldn't take them himself.
https://blogs.scientificamerican.com/news-blog/cholesterol-drug-scientist-receives-2008-09-12/
A 2006 profile of Endo noted that he briefly took Mevacor, a Merck statin produced with a fungal byproduct close to the one he discovered. But Endo stopped taking it, and when a doctor found he still had elevated LDL, he decreased his levels by exercising, he told the Wall Street Journal.
When asked why, he gave the Journal a cryptic answer in the form of a Japanese proverb: "The indigo dyer wears white trousers."
Perhaps it would inspire confidence if all the Moderna, Merck, and AstraZeneca employees (particularly executives) were enrolled in the trials.
I'm not anti-vax at all but as a healthy 46 year old woman with no underlying conditions or obesity, I will have some real reservations about taking a vaccine that has been Leroy Jenkinsed through testing protocols to prevent a disease that is statistically unlikely to be dangerous to me, much less fatal. And I have major reservations about giving it to my kids.
Now if I were older or had other risk factors I'd feel differently. And a lot will depend on what the vaccine actually ends up being and how well it works, and what the known side effects are. But I understand why folks might be hesitant about It.
Now if I were older or had other risk factors I'd feel differently. And a lot will depend on what the vaccine actually ends up being and how well it works, and what the known side effects are. But I understand why folks might be hesitant about It.
Major props to you for working Leroy Jenkins into a COVID vaccine discussion.jenn96 said:
I'm not anti-vax at all but as a healthy 46 year old woman with no underlying conditions or obesity, I will have some real reservations about taking a vaccine that has been Leroy Jenkinsed through testing protocols to prevent a disease that is statistically unlikely to be dangerous to me, much less fatal. And I have major reservations about giving it to my kids.
Now if I were older or had other risk factors I'd feel differently. And a lot will depend on what the vaccine actually ends up being and how well it works, and what the known side effects are. But I understand why folks might be hesitant about It.
weren't you saying in another thread that you'd be the last in line by priority to get one?
but here you say you don't want it
but here you say you don't want it
Nice work Encyclopedia Brown. No, both are true. I would be among the last in line to get a vaccine based on need, and I also don't know that I want to take a brand-new, rushed into production vaccine since I am low-risk. My point in the other thread was that I feel like we're years away from a vaccine being ready to take for the general public. Far too many people are acting like a vaccine will fix everything, and not factoring in that it will take time to get disseminated through the general population and a lot of people are going to be nervous about taking it.
I would love to be wrong because a readily available vaccine would help a lot for making people feel safer, and would obviously help keep cases down, but also think vaccine compliance will be an issue. I can't imagine I'm the only person who is generally pro-vaccine and really wants to get the economy back going with fewer cases and hospitalizations but is also nervous about just how rushed this thing will be, and how many corners will be cut.
Edited to add: I guess I'm saying that I think lots of people who are low-risk will want to take a pass at first to see if there are long-term complications to the vaccine. But too many people do that and then the vaccine serves a limited purpose, since there has to be a level of vaccinated herd immunity in the population for a vaccine to be effective. It's going to be a mess.
No, both are true. I would be among the last in line to get a vaccine based on need, and I also don't know that I want to take a brand-new, rushed into production vaccine since I am low-risk. My point in the other thread was that I feel like we're years away from a vaccine being ready to take for the general public. Far too many people are acting like a vaccine will fix everything, and not factoring in that it will take time to get disseminated through the general population and a lot of people are going to be nervous about taking it. I would love to be wrong because a readily available vaccine would help a lot for making people feel safer, and would obviously help keep cases down, but also think vaccine compliance will be an issue. I can't imagine I'm the only person who is generally pro-vaccine and really wants to get the economy back going with fewer cases and hospitalizations but is also nervous about just how rushed this thing will be, and how many corners will be cut.
Edited to add: I guess I'm saying that I think lots of people who are low-risk will want to take a pass at first to see if there are long-term complications to the vaccine. But too many people do that and then the vaccine serves a limited purpose, since there has to be a level of vaccinated herd immunity in the population for a vaccine to be effective. It's going to be a mess.
i have no problem taking an mRNA vaccine
I agree. This vaccine has huge promise not just for COVID but multiple infections and even possibly cancer cells.Harry Stone said:
i have no problem taking an mRNA vaccine
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Silky Johnston said:
If a huge portion of the population isn't willing to wear a mask, what makes you think they'll get a vaccine?
I think that's definitely a different mental hurdle, just as there will be people who are perfectly willing to wear a mask who won't be willing to get a vaccine.
But I don't know how much participation we actually need to get R<<1 anyway.
There is clearly something which causes the spread to lessen considerably well before we would get anything close to observable herd immunity, and independent of mitigation efforts.
This has played out across the globe, that after the first big spike this thing subsides. So there is something there, whether that's T-cell response or inherent immunity, in addition to the observed infected who have recovered, which helps put a lid on this thing.
Even a relatively small percentage of vaccine participation would represent a substantial move toward a de facto herd immunity.
I just got approved to be apart of the Moderna phase 3 trial.
Should I do it? I will be talking with my uncle about it who is a doctor.
Should I do it? I will be talking with my uncle about it who is a doctor.
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