Preprint: Herd Immunity Threshold of 10-20%

23,664 Views | 217 Replies | Last: 5 yr ago by Keegan99
buffalo chip
How long do you want to ignore this user?
S
AgE Doc said:




Of the total 712 that ultimately tested positive on the Diamond Princess,

The ship had 1,045 person Crew.
The ship had 2,666 passengers.


1045 + 2666 = 3711

712 DIVIDED BY 3711 = 0.1918

It was not two distinct populations on the Diamond Princess, just one...
Goodbull_19
How long do you want to ignore this user?
AG
NASAg03 said:

Considering NY has 20%+ antibodies, and has been steady at 800 cases / day and 40 deaths / day since June 8, I'd say there's something to this theory.


From my understanding NY is still heavy in mitigation strategies.
terradactylexpress
How long do you want to ignore this user?
Read the thread
AgE Doc
How long do you want to ignore this user?
AG
Spain is beginning to provide more evidence to prove this pandemic doesn't burn out on it's own at 10-20% Infectious Herd Immunity...


Spain sees resurgence in previously hard hit Barcelona, iCataluna province.


On the two hardest hit regions of Spain sees 5,700+ New Cases in Last Week as Barcelona lets down it's guard.

BOTTOM LINE To keep things moving in the right direction...
Wear a mask in public settings at all times when indoors.
Wear a mask in public settings when not able to physically distance from others outside.
Avoid large indoor gatherings.
Give schools the support they need to be able to follow CDC guidelines.
DadHammer
How long do you want to ignore this user?
AG
Proof lock downs don't work to eliminate the virus. As soon as you begin to come out infections go back up. This is predictable and expected.

Be cautious, distance, wear mask, do what you can to slow the spread. We need it to slow burn it's way out.

Good list by AgE Doc.
Goodbull_19
How long do you want to ignore this user?
AG
If we don't have a 10-20% burnout and lockdowns only delay the inevitable, then in my mind what are we doing? What is the goal?
Goodbull_19
How long do you want to ignore this user?
AG
AgE Doc said:

Spain is beginning to provide more evidence to prove this pandemic doesn't burn out on it's own at 10-20% Infectious Herd Immunity...


Spain sees resurgence in previously hard hit Barcelona, iCataluna province.


On the two hardest hit regions of Spain sees 5,700+ New Cases in Last Week as Barcelona lets down it's guard.

BOTTOM LINE To keep things moving in the right direction...
Wear a mask in public settings at all times when indoors.
Wear a mask in public settings when not able to physically distance from others outside.
Avoid large indoor gatherings.
Give schools the support they need to be able to follow CDC guidelines.


AgE what are your thoughts on burnout %? If not 10-20%, 30-40%? Or 50-60%?
SirLurksALot
How long do you want to ignore this user?
Goodbull_19 said:

If we don't have a 10-20% burnout and lockdowns only delay the inevitable, then in my mind what are we doing? What is the goal?


The de facto goal is lockdown until a vaccine is readily available. However, no one wants to admit that because it means many more months of restrictions.
PJYoung
How long do you want to ignore this user?
AG
If the burnout is 20% then I'm not sure I understand how some places like Madrid were at like 57% a few weeks ago.

A province in Italy was at 71% if I'm not mistaken.

EDIT: I see that point was brought up.
Aggie95
How long do you want to ignore this user?
AG
What was 57% in Madrid?

The population of Madrid is about 6 million...I don't think 3.5 million have/had Covid.
Aggie95
How long do you want to ignore this user?
AG
If burnout doesn't occur at any acceptable level...is there a level where the virus becomes less virulent, weaker, etc?
buffalo chip
How long do you want to ignore this user?
S
It seems to me that the concept of burnout or herd immunity is not an on-off, yes/no reality. Reaching burnout or herd immunity does not require that there are ZERO deaths from COVID19.

Michael Levitt, in his tweet (set out above) that makes a prediction for the USA of less than 170,000 deaths at the point that burnout is reached, defines burnout as that point in time when there are no longer "excess deaths" when calculating deaths from ALL causes. He does not say that there will be ZERO deaths from COVID19, just that the infection rate of the virus will no longer be capable of rising.

At this point in time, based on where we are with COVID19, nobody knows what the outcome will be. Michael Levitt does not know. He is making a projection from all of the data that is available to him, using his experience and knowledge to do so. But, he does not know. I hope he is right with his current projection, that the burnout is close to 20% infection of the population and that we are closing in on that number in the USA. That means that we can get back to "normal" sooner rather than later.

I truly appreciate the vigorous debate here on TA. You guys are amazing! Your abilities to gather the data and information and then to debate its meaning is extremely helpful. Thank you! Kudos also to the doctors and other health professionals that have taken the time to describe their experiences and impart their acquired knowledge. I also appreciate those, like me, who do not have any specialized knowledge or experience, who are just trying to follow this strange new world and gain some understanding that we might not otherwise be able to have.
flogmat
How long do you want to ignore this user?
AG
I've read a few different articles that have highlighted burnout, and I think the confusion that people have on the idea is that they don't quite understand that the burnout only happens at a micro level across certain populations at a specific time.

The way it has been described to me is this: early on, when there are few infections, it can more easily spread. Think of it as having 10 people in a room at one time with one infection - that person might infect 7 others. Now, as time passes, and you have 10 people in a room, with 5 already infected, there are less available hosts and so the system slowly burns out. 20% seems like just an average, but I do think this makes sense in a given population.

The reason why you'll see a county like Spain have a resurgence is that the original breakout was in one geographic area, and the new breakout is in another that hasn't yet gotten to that burnout threshold.
Keegan99
How long do you want to ignore this user?
AG
That's also what we're seeing in the US.

The northeast and parts of the midwest hit burnout.

The sunbelt did not. (With latitude and seasonality playing a role, I believe)

Now we're getting there.
jeffdjohnson
How long do you want to ignore this user?
Goodbull_19 said:

If we don't have a 10-20% burnout and lockdowns only delay the inevitable, then in my mind what are we doing? What is the goal?
The rate of transmission may tip under 1 (burnout) due to a combination of things: some level of herd immunity, mask wearing, improved hygiene, social distancing, work from home, etc... It might be hard to tease out the exact burnout threshold with so many other mitigating factors effecting the overall Rt. Perhaps the 20% burnout number is indeed valid when these other mitigation factors are in place. I don't think we will be able to know the answer until a COVID-19 postmortem is performed in future years.

In the meantime I believe the effects of another lockdown effort would be far more disastrous than COVID-19 itself. People need to take the appropriate best effort precautions while continuing to live without fear.
F2Aggie
How long do you want to ignore this user?
AG

Have not seen this discussed.

Thoughts on different strains of covid? Impact on the 10-20% HIT?

Are different strains hitting different parts of the country/world?

https://www.ksat.com/news/local/2020/07/25/there-are-six-different-types-of-covid-19-researchers-say/

Sq 17
How long do you want to ignore this user?
Aggie95 said:

What was 57% in Madrid?

The population of Madrid is about 6 million...I don't think 3.5 million have/had Covid.
that was likely the + test rate and the only people being tested were either syptomatic or had exposure and not representative of the underlying population. that being said the underlying population in the hard hit areas was likely in 20% range
Sq 17
How long do you want to ignore this user?
jeffdjohnson said:

Goodbull_19 said:

If we don't have a 10-20% burnout and lockdowns only delay the inevitable, then in my mind what are we doing? What is the goal?
The rate of transmission may tip under 1 (burnout) due to a combination of things: some level of herd immunity, mask wearing, improved hygiene, social distancing, work from home, etc... It might be hard to tease out the exact burnout threshold with so many other mitigating factors effecting the overall Rt. Perhaps the 20% burnout number is indeed valid when these other mitigation factors are in place. I don't think we will be able to know the answer until a COVID-19 postmortem is performed in future years.


if the soceity is doing large scale mitigation strategies to keep rate of transmission under 1 then it is not burned out. We will never have a Covid Post Mortem that is belived by most Americans
JamesE4
How long do you want to ignore this user?
AG
F2Aggie said:


Have not seen this discussed.

Thoughts on different strains of covid? Impact on the 10-20% HIT?

Are different strains hitting different parts of the country/world?

https://www.ksat.com/news/local/2020/07/25/there-are-six-different-types-of-covid-19-researchers-say/


the headline does not reflect the article. The headline implies different COVID versions, yet the article discusses different sets of symptoms, which could just be (and probably is) different individual reactions to the same virus.
AgE Doc
How long do you want to ignore this user?
AG
Goodbull_19 said:

If we don't have a 10-20% burnout and lockdowns only delay the inevitable, then in my mind what are we doing? What is the goal?
The goal for me would be to do the simple things (pick the low hanging fruit) to keep rate of transmission low while still keeping most of the economy open and the schools open. Masks at all time indoors when in public places. Mask when you can't physically distance outside. Avoid large indoor gatherings. Make hand sanitizer abundantly available in public settings.

I would try to keep cases low enough so that labs could give 24 hour results 100% of the time. I would have health departments as cases get lower do a better job of contact tracing. Right now in Texas they are so overwhelmed that they aren't able to do what is typically recommended in John's Hopkins school of public health contact tracing course. Once that is accomplished you can really keep the new daily case numbers suppressed as you push the R-naught well below 1.

I would try to postpone as many cases/deaths as long as reasonably possible without shutting down the entire economy and schools until advances in treatments (ICU Mortality went from 60% to 40% from March to June) and ultimately a vaccine are able to save some of those lives.

AgE Doc
How long do you want to ignore this user?
AG
flogmat said:


The reason why you'll see a county like Spain have a resurgence is that the original breakout was in one geographic area, and the new breakout is in another that hasn't yet gotten to that burnout threshold.
One of the main sources of the resurgence in Spain is the Cataluna Province which encompasses Barcelona. This area was one of the hardest hit areas of the country during their first wave, just barely trailing Madrid in cases per capita. Below are screen shots from the article I linked above, that you may not have been able to see without a subscription to the newspaper.





AgE Doc
How long do you want to ignore this user?
AG
F2Aggie said:


Have not seen this discussed.

Thoughts on different strains of covid? Impact on the 10-20% HIT?

Are different strains hitting different parts of the country/world?

https://www.ksat.com/news/local/2020/07/25/there-are-six-different-types-of-covid-19-researchers-say/


I think that article is saying that there are different 6 common symptom patterns that COVID-19 can cause. Not everyone infected with the same strain will experience the same exact symptoms for numerous reasons. Their have been some mutations that have happened with COVID-19, and some forms have been speculated to potentially be more contagious than others without necessarily being more or less virulent. However in any given community their will be a primary version of COVID-19 and it will be capable of producing any one of the six different symptom patterns.
PJYoung
How long do you want to ignore this user?
AG
Aggie95 said:

What was 57% in Madrid?

The population of Madrid is about 6 million...I don't think 3.5 million have/had Covid.

Ah yeah I don't know what I was looking at.

https://www.bmj.com/content/370/bmj.m2728

Quote:

The results of the first nationwide population based epidemiological study of SARS-Cov-2 seroprevalence, conducted across Spain, reveal a national prevalence of only 5%, making global efforts to deliver herd immunity through natural infection both "unethical and unachievable," according to experts.

In a survey carried out between 27 April and 11 May and involving more than 61 000 participants in nearly 36 000 households, Marina Polln, professor at Spain's National Centre for Epidemiology in Madrid, with colleagues from the ENE-COVID study group, used two methods to detect anti-covid-19 antibodies: a point of care test and a laboratory immunoassay.1

Although they targeted IgG antibodies against different viral proteins, both tests yielded similar findings, with the point of care test detecting a 5.0% (95% confidence interval 4.7-5.4) nationwide seroprevalence and the immunoassay a 4.6% seroprevalence (95% CI 4.3-5.0).

"Despite the high impact of covid-19 in Spain, prevalence estimates remain low and are clearly insufficient to provide herd immunity," the paper's authors said. "This cannot be achieved without accepting the collateral damage of many deaths in the susceptible population and overburdening health systems. In this situation, social distance measures and efforts to identify and isolate new cases and their contacts are imperative for future epidemic control."
eric76
How long do you want to ignore this user?
AG
flogmat said:

I've read a few different articles that have highlighted burnout, and I think the confusion that people have on the idea is that they don't quite understand that the burnout only happens at a micro level across certain populations at a specific time.

The way it has been described to me is this: early on, when there are few infections, it can more easily spread. Think of it as having 10 people in a room at one time with one infection - that person might infect 7 others. Now, as time passes, and you have 10 people in a room, with 5 already infected, there are less available hosts and so the system slowly burns out. 20% seems like just an average, but I do think this makes sense in a given population.

The reason why you'll see a county like Spain have a resurgence is that the original breakout was in one geographic area, and the new breakout is in another that hasn't yet gotten to that burnout threshold.
More importantly, if having 10 people in a room, the person might infect 7 of them, when people react and practice social distancing, you might have 3 people in the room and so the number that one person may infection are much lower.

It's almost as if the number who are immune is higher by including those who cannot be infected because they aren't exposed.

It should be clear that there is no one magic number for herd immunity -- a great deal depends on how people react to the outbreak and what they do to avoid being exposed.
eric76
How long do you want to ignore this user?
AG
Sq 17 said:

jeffdjohnson said:

Goodbull_19 said:

If we don't have a 10-20% burnout and lockdowns only delay the inevitable, then in my mind what are we doing? What is the goal?
The rate of transmission may tip under 1 (burnout) due to a combination of things: some level of herd immunity, mask wearing, improved hygiene, social distancing, work from home, etc... It might be hard to tease out the exact burnout threshold with so many other mitigating factors effecting the overall Rt. Perhaps the 20% burnout number is indeed valid when these other mitigation factors are in place. I don't think we will be able to know the answer until a COVID-19 postmortem is performed in future years.


if the soceity is doing large scale mitigation strategies to keep rate of transmission under 1 then it is not burned out. We will never have a Covid Post Mortem that is belived by most Americans
More importantly, the shorter the immunity acquired from the disease, the harder it may be to ever achieve herd immunity as those who were once immune become susceptible once more.
Sq 17
How long do you want to ignore this user?
the Florida Marlins hit a 20% infection rate ( as of today 14 players and staff ) so i guess the other members of the team are safe.

post has been reworded i was too flippant in my original post
Cone's criticism of original tone is valid
cone
How long do you want to ignore this user?
AG
that's not how it works but good to know you're having fun during a deadly pandemic
AgsMyDude
How long do you want to ignore this user?
AG
Sq 17 said:

great news for the Florida Marlins 20% ( as of today 14 players and staff ) have caught the Covid so i guess the other members of the team are safe.


The whole state of Florida must be safe too!
Sq 17
How long do you want to ignore this user?
read the whole thread I have been consistently pointing out how a burnout rate at 20% seemed overly optimistic
that being said i will reword the offending post
Bruce Almighty
How long do you want to ignore this user?
AG
cone said:

that's not how it works but good to know you're having fun during a deadly pandemic


Lighten up, it was a joke.
cone
How long do you want to ignore this user?
AG
does that mean the ceiling for age is now 80 (or maybe less)?

since this thing kills 1 in 6 out that age and older? no lasting immunity means it'll eventually get them all and the population decay will be very rapid.
cone
How long do you want to ignore this user?
AG
maybe just delete the whole thing
Sq 17
How long do you want to ignore this user?
i have apologized for being flippant and reworded the post. My underlying point is relevant to the discussion in the thread which is a 20% burnout rate a feature of the virus or a result of other forces and the actual burnout rate is significantly highher.
Aggie95
How long do you want to ignore this user?
AG
Whether the 20% burnout is a reality or wish...I cannot think of a worse "experimental group" than a team of 30-35 guys staying in different cities every 3 to 4 days for the next 3 months.
DadHammer
How long do you want to ignore this user?
AG
cone said:

does that mean the ceiling for age is now 80 (or maybe less)?

since this thing kills 1 in 6 out that age and older? no lasting immunity means it'll eventually get them all and the population decay will be very rapid.

I am guessing immunity will be long lasting thanks to T cells.
 
×
subscribe Verify your student status
See Subscription Benefits
Trial only available to users who have never subscribed or participated in a previous trial.