This season seems to be setting up a "Dark" sort of story.
Predictions (spoiler tagging for those that don't like reading them)
Loki created the TVA originally, setting up a knot his past, present, and future can't escape. The need for the TVA is why they allowed the time travel in End Game when they prune seemingly every other instance, as it creates the Loki they need to create the TVA jumping in time to continually destroy, but then continually creating it again to protect the sacred timeline.
Timely is actually HWR. Loki will zap back to the point in time before he is disentegrated, save him and everyone else by sacrificing himself, allowing Timely to take on the HWR persona and become in charge of the TVA. Not sure yet if he is also Kang the Conqueror or if that version of him is what causes him to start pruning every other timeline.
Renslayers original self has to come into play at some point next episode. I expect Miss Minutes to try and sabotage HWR being in charge, which ends up killing her. HWR will need to recreate her in order to ensure the loop continues.